{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:28:11Z","timestamp":1790897291466,"version":"4.1.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000124","name":"Office of Research on Women's Health","doi-asserted-by":"crossref","award":["K12HD043441"],"award-info":[{"award-number":["K12HD043441"]}],"id":[{"id":"10.13039\/100000124","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n            Objectives\u2003We sought to describe characteristics of mechanically ventilated pregnant patients, evaluate utilization of low-tidal-volume ventilation (LTVV) and high-tidal-volume ventilation (HTVV) by trimester, and describe maternal and fetal outcomes by ventilation strategy.<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective cohort study of pregnant women with mechanical ventilation for greater than 24\u2009hours between July 2012 and August 2020 at a tertiary care academic medical center. We defined LTVV as average daily tidal volume 8\u2009mL\/kg of less of predicted body weight, and HTVV as greater than 8\u2009mL\/kg. We examined demographic characteristics, maternal and fetal characteristics, and outcomes by ventilation strategy.<\/jats:p><jats:p>\n            Results\u2003We identified 52 ventilated pregnant women, 43 had LTVV, and 9 had HTVV. Acute respiratory distress syndrome occurred in 73% (N\u2009=\u200938) of patients, and infection was a common indication for ventilation (N\u2009=\u200933, 63%). Patients had LTVV more often than HTVV in all trimesters. Obstetric complications occurred frequently, 21% (N\u2009=\u200911) experienced preeclampsia or eclampsia, and among 43 patients with available delivery data, 60% delivered preterm (N\u2009=\u200926) and 16% had fetal demise (N\u2009=\u20097).<\/jats:p><jats:p>\n            Conclusion\u2003LTVV was utilized more often than HTVV among pregnant women in all trimesters. There was a high prevalence of maternal and fetal morbidity and fetal mortality among our cohort.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2207-9917","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T01:11:35Z","timestamp":1699578695000},"page":"e111-e119","source":"Crossref","is-referenced-by-count":3,"title":["Lung Protective Ventilation during Pregnancy: An Observational Cohort Study"],"prefix":"10.1055","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5519-5894","authenticated-orcid":false,"given":"Yasaswi","family":"Kislovskiy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Women's Institute, Allegheny Health Network, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisse","family":"Hauspurg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, UPMC Magee-Women's Hospital, Pittsburgh, Pennsylvania"},{"name":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenell","family":"Donadee","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, UPMC Magee-Women's Hospital, Pittsburgh, Pennsylvania"},{"name":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavan","family":"Murugan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1056\/NEJMoa1301082","article-title":"A trial of intraoperative low-tidal-volume ventilation in abdominal surgery","volume":"369","author":"E Futier","year":"2013","journal-title":"N Engl J Med"},{"issue":"18","key":"ref2","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","volume":"342","author":"R G Brower","year":"2000","journal-title":"N Engl J Med"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1378\/chest.14-2365","article-title":"Critical illness in pregnancy: part II: common medical conditions complicating pregnancy and puerperium","volume":"148","author":"K K Guntupalli","year":"2015","journal-title":"Chest"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1007\/s00134-010-1922-5","article-title":"Noninvasive ventilation in H1N1-correlated severe ARDS in a pregnant woman: please, be cautious!","volume":"36","author":"L Cabrini","year":"2010","journal-title":"Intensive Care Med"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/GRF.0000000000000067","article-title":"ARDS in pregnancy","volume":"57","author":"A G Duarte","year":"2014","journal-title":"Clin Obstet Gynecol"},{"issue":"15","key":"ref6","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1001\/jama.2010.479","article-title":"Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States","volume":"303","author":"A M Siston","year":"2010","journal-title":"JAMA"},{"issue":"44","key":"ref7","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.15585\/mmwr.mm6944e3","article-title":"Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status - 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