{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:15:44Z","timestamp":1790720144354,"version":"4.1.0"},"reference-count":53,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>International guidelines emphasise the role of local therapies (LT) for the\n                    treatment of advanced adrenocortical carcinoma (ACC). However, large studies are\n                    lacking in this field. Therefore, we performed a review of the literature to\n                    synthesise current evidence and develop clinical guidance. PubMed database was\n                    searched for systematic literature. We identified 119 potentially relevant\n                    articles, of which 21 could be included in our final analysis. All were\n                    retrospective and reported on 374 patients treated with LT for advanced ACC (12\n                    studies on radiotherapy, 3 on transarterial chemoembolisation and\n                    radioembolisation, 4 on image-guided thermal ablation [radiofrequency, microwave\n                    ablation, and cryoablation, and two studies reporting treatment with several\n                    different LT]). Radiotherapy was frequently performed with palliative intention.\n                    However, in most patients, disease control and with higher dosage also partial\n                    responses could be achieved. Data for other LT were more limited, but also point\n                    towards local disease control in a significant percentage of patients. Very few\n                    studies tried to identify factors that are predictive on response. Patients with\n                    a disease-free interval after primary surgery of more than 9 months and\n                    lesions&lt;5\u2009cm might benefit most. Underreporting of toxicities\n                    may be prevalent, but LT appear to be relatively safe overall. Available\n                    evidence on LT for ACC is limited. LT appears to be safe and effective in cases\n                    with limited disease and should be considered depending on local expertise in a\n                    multidisciplinary team discussion.<\/jats:p>","DOI":"10.1055\/a-2209-6022","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T23:32:57Z","timestamp":1704324777000},"page":"91-98","source":"Crossref","is-referenced-by-count":18,"title":["Current Evidence on Local Therapies in Advanced Adrenocortical\n                    Carcinoma"],"prefix":"10.1055","volume":"56","author":[{"given":"Otilia","family":"Kimpel","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine,\n                    University Hospital, University of W\u00fcrzburg, W\u00fcrzburg,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Dischinger","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine,\n                    University Hospital, University of W\u00fcrzburg, W\u00fcrzburg,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Altieri","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine,\n                    University Hospital, University of W\u00fcrzburg, W\u00fcrzburg,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmina Teresa","family":"Fuss","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine,\n                    University Hospital, University of W\u00fcrzburg, W\u00fcrzburg,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Hospital, University of\n                    W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Kickuth","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, University\n                    Hospital, University of W\u00fcrzburg, W\u00fcrzburg,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kroiss","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine,\n                    University Hospital, University of W\u00fcrzburg, W\u00fcrzburg,\n                    Germany"},{"name":"Department of Internal Medicine IV, University Hospital,\n                    Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\n                    Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fassnacht","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Medicine,\n                    University Hospital, University of W\u00fcrzburg, W\u00fcrzburg,\n                    Germany"},{"name":"Comprehensive Cancer Center Mainfranken, University of\n                    W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1530\/EJE-21-0510","article-title":"S-GRAS score for prognostic classification of adrenocortical carcinoma: an\n                    international, multicenter ENSAT study","volume":"186","author":"Y S Elhassan","year":"2021","journal-title":"Eur J Endocrinol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.annonc.2020.08.2099","article-title":"Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO-EURACAN\n                    Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"31","author":"M Fassnacht","year":"2020","journal-title":"Ann Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1055\/a-0715-1946","article-title":"Advanced adrenocortical carcinoma - what to do when first-line therapy\n                    fails?","volume":"127","author":"F Megerle","year":"2019","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.path.2019.08.010","article-title":"Treatment of adrenocortical carcinoma","volume":"12","author":"A Vaidya","year":"2019","journal-title":"Surg Pathol Clin"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.eururo.2013.11.006","article-title":"Prognostic role of overt hypercortisolism in completely operated patients with\n                    adrenocortical cancer","volume":"65","author":"A Berruti","year":"2014","journal-title":"Eur Urol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ecl.2015.03.001","article-title":"Adrenocortical carcinoma","volume":"44","author":"E Baudin","year":"2015","journal-title":"Endocrinol Metab Clin North Am"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.soc.2015.08.011","article-title":"Surgical management of adrenocortical carcinoma: an evidence-based approach","volume":"25","author":"J Datta","year":"2016","journal-title":"Surg Oncol Clin N Am"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/cncr.24030","article-title":"Limited prognostic value of the 2004 International Union Against Cancer staging\n                    classification for adrenocortical carcinoma: proposal for a Revised TNM\n                    Classification","volume":"115","author":"M Fassnacht","year":"2009","journal-title":"Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-18-0608","article-title":"European Society of Endocrinology Clinical Practice Guidelines on the management\n                    of adrenocortical carcinoma in adults, in collaboration with the European\n                    Network for the Study of Adrenal Tumors","volume":"179","author":"M Fassnacht","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"ref10","first-page":"963","article-title":"An eleven-year experience with adrenocortical carcinoma","volume":"112","author":"R F Pommier","year":"1992","journal-title":"Surgery"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s10434-999-0719-7","article-title":"Long-term survival after 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of Clinical Endocrinology Disease State Clinical Review on\n                    the evaluation and management of adrenocortical carcinoma in an adult: a\n                    practical approach","volume":"26","author":"K Kiseljak-Vassiliades","year":"2020","journal-title":"Endocr Pract"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"101434","DOI":"10.1016\/j.beem.2020.101434","article-title":"Next-generation therapies for adrenocortical carcinoma","volume":"34","author":"B Altieri","year":"2020","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1210\/jc.2012-2559","article-title":"The role of surgery in the management of recurrent adrenocortical carcinoma","volume":"98","author":"I Erdogan","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/resp.13870","article-title":"Radiotherapy treatment for lung cancer: current status and future\n                    directions","volume":"25","author":"S K Vinod","year":"2020","journal-title":"Respirology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.3390\/curroncol28040257","article-title":"Extreme hypofractionation with SBRT in localized prostate cancer","volume":"28","author":"M A G\u00f3mez-Aparicio","year":"2021","journal-title":"Curr Oncol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1200\/JCO.22.01482","article-title":"Oligometastases: emerging evidence","volume":"40","author":"W Liu","year":"2022","journal-title":"J Clin Oncol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.ijrobp.2010.04.030","article-title":"Adjuvant and definitive radiotherapy for adrenocortical carcinoma","volume":"80","author":"A Sabolch","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1210\/jc.2019-00029","article-title":"Adjuvant radiation improves recurrence-free survival and overall survival in\n                    adrenocortical carcinoma","volume":"104","author":"L A Gharzai","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.6004\/jnccn.2021.7035","article-title":"Benefit of postoperative radiotherapy for patients with nonmetastatic\n                    adrenocortical carcinoma: a population-based analysis","volume":"19","author":"K Wu","year":"2021","journal-title":"J Natl Compr Canc Netw"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1210\/jc.2012-2367","article-title":"A retrospective cohort analysis of the efficacy of adjuvant radiotherapy after\n                    primary surgical resection in patients with adrenocortical carcinoma","volume":"98","author":"M A Habra","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1590\/s1677-5538.ibju.2017.0095","article-title":"Adjuvant radiotherapy for the primary treatment of adrenocortical carcinoma: are\n                    we offering the best?","volume":"43","author":"V Srougi","year":"2017","journal-title":"Int Braz J Urol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/PPO.0b013e31829e3221","article-title":"Role of radiotherapy in adrenocortical carcinoma","volume":"19","author":"J Ho","year":"2013","journal-title":"Cancer J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41416-022-02082-0","article-title":"Efficacy and safety of radiation therapy in advanced adrenocortical\n                    carcinoma","volume":"128","author":"O Kimpel","year":"2023","journal-title":"Br J Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.3390\/cancers14112730","article-title":"Loco-regional therapies in oligometastatic adrenocortical carcinoma","volume":"14","author":"C Roux","year":"2022","journal-title":"Cancers (Basel)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the\n                    European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"J D Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/BF03346675","article-title":"Response to radiation therapy in adrenocortical carcinoma","volume":"33","author":"I G Hermsen","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3109\/02841867609131965","article-title":"Radiation therapy of adrenal cortical carcinoma","volume":"15","author":"B Percarpio","year":"1976","journal-title":"Acta Radiol Ther Phys Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/1097-0142(197907)44:1<239::AID-CNCR2820440139>3.0.CO;2-R","article-title":"Adrenal cortical carcinoma: a clinical and pathologic study of 49 cases","volume":"44","author":"D R King","year":"1979","journal-title":"Cancer"},{"key":"ref32","first-page":"926","article-title":"Adrenal cortical carcinoma--a continuing challenge","volume":"94","author":"D J Henley","year":"1983","journal-title":"Surgery"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/1097-0142(19830815)52:4<707::AID-CNCR2820520424>3.0.CO;2-N","article-title":"Adrenal cortical carcinoma. A study of 77 cases","volume":"52","author":"S Nader","year":"1983","journal-title":"Cancer"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/1097-0142(19890801)64:3<765::AID-CNCR2820640333>3.0.CO;2-I","article-title":"Adrenal cortical carcinoma","volume":"64","author":"S Venkatesh","year":"1989","journal-title":"Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0009-9260(87)80331-8","article-title":"Adrenal cortical carcinoma: survival after radiotherapy","volume":"38","author":"B J Magee","year":"1987","journal-title":"Clin Radiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00000421-199104000-00015","article-title":"Radiation therapy for adjunctive treatment of adrenal cortical carcinoma","volume":"14","author":"A M Markoe","year":"1991","journal-title":"Am J Clin 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adrenocortical carcinoma","volume":"21","author":"J Cazejust","year":"2010","journal-title":"J Vasc Interv Radiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1002\/cam4.3740","article-title":"Long-term outcomes in patients with advanced adrenocortical carcinoma after\n                    image-guided locoregional ablation or embolization","volume":"10","author":"M Mauda-Havakuk","year":"2021","journal-title":"Cancer Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12672-019-00367-0","article-title":"Metastatic adrenocortical carcinoma: a single institutional experience","volume":"10","author":"D H Owen","year":"2019","journal-title":"Horm Cancer"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000200804","article-title":"A twelve-year experience with adrenal cortical carcinoma in a single\n                    institution: long-term survival after surgical treatment and transcatheter\n   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Radiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.1002\/cncr.26128","article-title":"CT-guided percutaneous microwave ablation of adrenal malignant carcinoma:\n                    preliminary results","volume":"117","author":"X Li","year":"2011","journal-title":"Cancer"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1245\/s10434-011-1564-z","article-title":"Liver resection and ablation for metastatic adrenocortical carcinoma","volume":"18","author":"R T Ripley","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"8291","DOI":"10.1007\/s00330-021-07834-9","article-title":"Drug-eluting beads TACE is safe and non-inferior to conventional TACE in HCC\n                    patients with TIPS","volume":"31","author":"W Fan","year":"2021","journal-title":"Eur Radiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2174\/1573405616999200819165709","article-title":"Non-surgical treatments for lung metastases in patients with soft tissue\n                    sarcoma: stereotactic body radiation therapy (SBRT) and radiofrequency ablation\n                    (RFA)","volume":"17","author":"C Tetta","year":"2021","journal-title":"Curr Med Imaging"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1002\/cam4.5125","article-title":"TACE versus TARE for patients with hepatocellular carcinoma: overall and\n                    individual patient level meta analysis","volume":"12","author":"A M Brown","year":"2023","journal-title":"Cancer Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s12094-021-02745-z","article-title":"Ytrrium-90 transarterial radioembolization in patients with gastrointestinal\n                    malignancies","volume":"24","author":"D Vi\u00f1al","year":"2022","journal-title":"Clin Transl Oncol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1055\/s-0043-117410","article-title":"Microwave ablation (MWA): basics, technique and results in primary and\n                    metastatic liver neoplasms - review article","volume":"189","author":"T J Vogl","year":"2017","journal-title":"Rofo"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2209-6022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:23:22Z","timestamp":1730813002000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2209-6022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":53,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,1,3]]},"published-print":{"date-parts":[[2024,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2209-6022","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}