{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:43:00Z","timestamp":1788388980833,"version":"build-2803163510"},"reference-count":315,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In early 2020, a global pandemic was announced due to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), known to cause COVID-19. Despite worldwide efforts,\n          there are only limited options regarding antiviral drug treatments for COVID-19. Although vaccines are now available, issues such as declining efficacy against different SARS-CoV-2 variants\n          and the aging of vaccine-induced immunity highlight the importance of finding more antiviral drugs as a second line of defense against the disease. Drug repurposing has been used to rapidly\n          find COVID-19 therapeutic options. Due to the lack of clinical evidence for the therapeutic benefits and certain serious side effects of repurposed antivirals, the search for an antiviral\n          drug against SARS-CoV-2 with fewer side effects continues. In recent years, numerous studies have included antiviral chemicals from a variety of plant species. A better knowledge of the\n          possible antiviral natural products and their mechanism against SARS-CoV-2 will help to develop stronger and more targeted direct-acting antiviral agents. The aim of the present study was to\n          compile the current data on potential plant metabolites that can be investigated in COVID-19 drug discovery and development. This review represents a collection of plant secondary\n          metabolites and their mode of action against SARS-CoV and SARS-CoV-2.<\/jats:p>","DOI":"10.1055\/a-2209-6357","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:32:41Z","timestamp":1699921961000},"page":"172-203","source":"Crossref","is-referenced-by-count":2,"title":["The Potential of Anti-coronavirus Plant Secondary Metabolites in COVID-19 Drug Discovery as an Alternative to Repurposed Drugs: A Review"],"prefix":"10.1055","volume":"90","author":[{"given":"Zahra","family":"Alipour","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Zarezadeh","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-7232","authenticated-orcid":false,"given":"Ali Akbar","family":"Ghotbi-Ravandi","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"4573","DOI":"10.2174\/138161206779010369","article-title":"Drug design targeting the main protease, the Achilles\u02bc heel of coronaviruses","volume":"12","author":"H Yang","year":"2006","journal-title":"Curr Pharm Des"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jmii.2020.03.022","article-title":"Genotype and phenotype of COVID-19: Their roles in 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Li","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/s41579-021-00630-8","article-title":"Structural biology of SARS-CoV-2 and implications for therapeutic development","volume":"19","author":"H Yang","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1016\/j.apsb.2021.05.007","article-title":"SARS-CoV-2 cell entry and targeted antiviral development","volume":"11","author":"Z Chen","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"5260","DOI":"10.1002\/jmv.27019","article-title":"Targeting the viral-entry facilitators of SARS-CoV-2 as a therapeutic strategy in COVID-19","volume":"93","author":"S Muralidar","year":"2021","journal-title":"J Med 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Lu","year":"2020","journal-title":"Lancet"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"P Zhou","year":"2020","journal-title":"Nature"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.micinf.2020.01.003","article-title":"Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China","volume":"22","author":"F Yu","year":"2020","journal-title":"Microbes Infect"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40249-020-00646-x","article-title":"Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: A scoping review","volume":"9","author":"S P Adhikari","year":"2020","journal-title":"Infect Dis Poverty"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"e00473-12","DOI":"10.1128\/mBio.00473-12","article-title":"Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans","volume":"3","author":"S van Boheemen","year":"2012","journal-title":"MBio"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/s0022-2836(03)00865-9","article-title":"Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage","volume":"331","author":"E J Snijder","year":"2003","journal-title":"J Mol Biol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The species severe acute respiratory syndrome-related coronavirus: Classifying 2019-nCoV and naming it SARS-CoV-2","volume":"5","author":"A E 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