{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:48:25Z","timestamp":1766159305188,"version":"3.37.3"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective We aimed to investigate cardiotrophin-1 (CT-1) concentrations in\n                    the serum of pregnant women with gestational diabetes mellitus (GDM).<\/jats:p><jats:p>\n          Materials and methods This prospective non-interventional cohort study was\n                    conducted with 160 pregnant women who applied to the Umraniye Training and\n                    Research Hospital, Department of Obstetrics and Gynecology between October 2022\n                    and May 2023. The GDM group was formed from 80 pregnant women who were diagnosed\n                    with GDM according to the 75-g OGTT. The control group consisted of 80 healthy\n                    pregnant women who were matched with the GDM group in terms of age and body mass\n                    index and had a normal 75-g OGTT result. Two groups were compared in terms of\n                    maternal serum CT-1 concentrations.<\/jats:p><jats:p>\n          Results Both groups were similar in terms of demographic features and the\n                    gestational week at blood sampling for CT-1 (p&gt;0.05 for each). The mean\n                    maternal serum CT-1 concentration was found to be 1420.9\u2009pg\/ml\n                    in the GDM group, while it was determined as 1455\u2009pg\/ml in the\n                    control group (p=0.738). When the GDM and control groups were divided\n                    into two subgroups, normal weight and overweight according to the\n                    participants\u2019 BMI, serum CT-1 concentrations were found to be similar in\n                    these four groups (p=0.084). When the GDM group was divided into two\n                    groups of diet-only and the insulin-using group for blood glucose regulation and\n                    compared with the control group, the three groups were also similar in terms of\n                    serum CT-1 concentrations (p=0.189).<\/jats:p><jats:p>\n          Conclusion CT-1 is an adipokine involved in the regulation of glucose\n                    metabolism and has been suggested to be associated with the pathophysiology of\n                    diabetes mellitus. In this study, serum CT-1 concentrations were found to be\n                    similar in the group with GDM and the group with normal glucose tolerance.\n                    Whether CT-1 contributes to the development of GDM is currently unclear and\n                    requires further investigation.<\/jats:p>","DOI":"10.1055\/a-2210-4215","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T23:59:12Z","timestamp":1703116752000},"page":"355-362","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of Serum Cardiotrophin-1 Concentrations in Pregnant\n                    Women with Gestational Diabetes Mellitus"],"prefix":"10.1055","volume":"228","author":[{"given":"Yegana","family":"Huseynli","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Umraniye Training and Research Hospital,\n                    Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-7199","authenticated-orcid":false,"given":"\u0130brahim","family":"Kale","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Umraniye Training and Research Hospital,\n                    Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Dizdar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Umraniye Training and Research Hospital,\n                    Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Muhcu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Maternal Fetal Unit, Umraniye Training and\n                    Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1097\/AOG.0000000000002501","article-title":"ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus","volume":"131","year":"2018","journal-title":"Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1001\/jama.2019.4981","article-title":"Management of preexisting diabetes in pregnancy: A review","volume":"321","author":"A-S Alexopoulos","year":"2019","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence\n                    estimates for 2021 and projections for 2045","volume":"183","author":"H Sun","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"109050","DOI":"10.1016\/j.diabres.2021.109050","article-title":"IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes\n                    Mellitus Prevalence for 2021 by International Association of Diabetes in\n                    Pregnancy Study Group\u2019s Criteria","volume":"183","author":"H Wang","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"ref5","first-page":"278","article-title":"Criteria for the oral glucose tolerance test in pregnancy","volume":"13","author":"J B O\u2019sullivan","year":"1964","journal-title":"Diabetes"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"9573","DOI":"10.3390\/ijerph17249573","article-title":"Gestational diabetes: overview with emphasis on medical management","volume":"17","author":"M Lende","year":"2020","journal-title":"Int J Environ Res Public 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and chromosomal localization","volume":"8","author":"D Pennica","year":"1996","journal-title":"Cytokine"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.cytogfr.2015.07.009","article-title":"Cardiotrophin-1: A multifaceted cytokine","volume":"26","author":"M L\u00f3pez-Yoldi","year":"2015","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1046\/j.1365-2613.1999.00114.x","article-title":"Cardiotrophin-1 (CT-1): a novel hypertrophic and cardioprotective agent:\n                    Cardiotrophin-1","volume":"80","author":"D S Latchman","year":"2001","journal-title":"Int J Exp Pathol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.cmet.2011.05.013","article-title":"Cardiotrophin-1 is a key regulator of glucose and lipid metabolism","volume":"14","author":"M J Moreno-Aliaga","year":"2011","journal-title":"Cell Metab"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e33","DOI":"10.1016\/j.ijcard.2013.08.112","article-title":"Increased cardiotrophin-1 in subjects with impaired glucose tolerance and newly\n                    diagnosed diabetes","volume":"169","author":"H-C Hung","year":"2013","journal-title":"Int J Cardiol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"E52","DOI":"10.1152\/ajpendo.00506.2007","article-title":"Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic\n                    syndrome","volume":"294","author":"C Natal","year":"2008","journal-title":"Am J Physiol-Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/biology8020024","article-title":"The expression of adipose tissue-derived cardiotrophin-1 in humans with\n                    obesity","volume":"8","author":"J Stephens","year":"2019","journal-title":"Biology"},{"key":"ref16","first-page":"925","article-title":"Pioglitazone inhibits hypertrophy induced by high glucose and insulin in\n                    cultured neonatal rat cardiomyocytes","volume":"62","author":"J Liu","year":"2007","journal-title":"Pharm"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"47572","DOI":"10.1074\/jbc.M403998200","article-title":"Effects of cardiotrophin on adipocytes","volume":"279","author":"S Zvonic","year":"2004","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e1218","DOI":"10.1097\/MD.0000000000001218","article-title":"Plasma cardiotrophin-1 as a marker of hypertension and diabetes-induced target\n                    organ damage and cardiovascular risk","volume":"94","author":"L Gamella-Pozuelo","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"17438","DOI":"10.1038\/srep17438","article-title":"Cardiotrophin-1 is inversely associated with obesity in non-diabetic\n                    individuals","volume":"5","author":"H-C Hung","year":"2015","journal-title":"Sci Rep"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1096\/fj.201600396RR","article-title":"Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and\n                    adipose core clock genes in mice and characterization of 24\u2013h\n                    circulating CT-1 profiles in normal-weight and overweight\/obese\n                    subjects","volume":"31","author":"M L\u00f3pez-Yoldi","year":"2017","journal-title":"FASEB J"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2210-4215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:49:29Z","timestamp":1730814569000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2210-4215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,20]]},"references-count":20,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2024,8,5]]},"published-print":{"date-parts":[[2024,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2210-4215","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2023,12,20]]}}}