{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:18:14Z","timestamp":1791497894245,"version":"4.3.4"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"12","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Department of Research and Development Region Kronoberg","award":["976437"],"award-info":[{"award-number":["976437"]}]},{"DOI":"10.13039\/100010805","name":"Medical Research Council of Southeast Sweden","doi-asserted-by":"crossref","award":["FORSS-963548"],"award-info":[{"award-number":["FORSS-963548"]}],"id":[{"id":"10.13039\/100010805","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background and study aims Single-operator peroral cholangioscopy (SOC) has gained increasing attention in modern biliary and pancreatic therapy and diagnosis. This procedure has shown higher rates of infectious complications than conventional endoscopic retrograde cholangiopancreatography (ERCP); therefore, many guidelines recommend antibiotic prophylaxis (AP). However, whether AP administration decreases infectious or overall adverse events (AEs) has been little studied. We aimed to study whether AP affects post-procedure infectious or overall AEs in ERCP with SOC.<\/jats:p><jats:p>\n            Patients and methods We collected data from the Swedish Registry for Gallstone Surgery and ERCP (GallRiks). Of the 124,921 extracted ERCP procedures performed between 2008 and 2021, 1,605 included SOC and represented the study population. Exclusion criteria were incomplete 30-day follow-up, ongoing antibiotic use, and procedures with unspecified indication. Type and dose of antibiotics were not reported. Post-procedure infectious complications and AEs at 30-day follow-up were the main outcomes.<\/jats:p><jats:p>\n            Results AP was administered to 1,307 patients (81.4%). In this group, 3.4% of the patients had infectious complications compared with 3.7% in the non-AP group. The overall AE rates in the AP and non-AP groups were 14.6% and 15.2%, respectively. The incidence of cholangitis was 3.1% in the AP group and 3.4% in the non-AP group. Using multivariable analysis, both infectious complications (odds ratio [OR] 0.92, 95% confidence interval [CI] 0.54\u20131.57) and AEs (OR 0.87, 95% CI 0.65\u20131.16) remained unaffected by AP administration.<\/jats:p><jats:p>\n            Conclusions No reduction in infectious complication rates and AEs was seen with AP administration for SOC. The continued need for AP in SOC remains uncertain.<\/jats:p>","DOI":"10.1055\/a-2210-6283","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:47:55Z","timestamp":1700009275000},"page":"E1177-E1183","source":"Crossref","is-referenced-by-count":6,"title":["Antibiotic prophylaxis and post-procedure infectious complications in endoscopic retrograde cholangiopancreatography with peroral cholangioscopy"],"prefix":"10.1055","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7281-9945","authenticated-orcid":false,"given":"Arvid","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Surgery, Lund University and Department of Surgery, Sk\u00e5ne University Hospital, Lund, Sweden"},{"name":"Department of Research and Development and Department of Surgery, Central Hospital, Region Kronoberg, V\u00e4xj\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Enochsson","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences, Surgery, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby","family":"Tingstedt","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Surgery, Lund University and Department of Surgery, Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greger","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Research and Development and Department of Surgery, Central Hospital, Region Kronoberg, V\u00e4xj\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4253\/wjge.v14.i2.63","article-title":"Peroral cholangioscopy: Update on the state-of-the-art","volume":"14","author":"A Subhash","year":"2022","journal-title":"World J Gastrointest Endosc"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10030132","article-title":"The expansion of cholangioscopy: established and investigational uses of SpyGlass in biliary and pancreatic disorders","volume":"10","author":"M Yodice","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1055\/a-1075-4080","article-title":"ERCP-related adverse events: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"52","author":"J-M Dumonceau","year":"2020","journal-title":"Endoscopy"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.gie.2010.08.058","article-title":"ERCP with cholangiopancreatoscopy may be associated with higher rates of complications than ERCP alone: a single-center experience","volume":"73","author":"A Sethi","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1055\/s-0034-1391990","article-title":"ERCP-guided cholangioscopy using a single-use system: nationwide register-based study of its use in clinical practice","volume":"47","author":"J L\u00fcbbe","year":"2015","journal-title":"Endoscopy"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1055\/a-1135-8980","article-title":"Using single-operator cholangioscopy for endoscopic evaluation of indeterminate biliary strictures: results from a large multinational registry","volume":"52","author":"MA Almadi","year":"2020","journal-title":"Endoscopy"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1007\/s00464-016-5221-2","article-title":"Usefulness of the single-operator cholangioscopy system SpyGlass in biliary disease: a single-center prospective cohort study and aggregated review","volume":"31","author":"W Laleman","year":"2017","journal-title":"Surg Endosc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1177\/2050640618764943","article-title":"Safety, diagnostic accuracy and therapeutic efficacy of digital single-operator cholangioscopy","volume":"6","author":"F Lenze","year":"2018","journal-title":"United European Gastroenterol J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.3390\/jcm10081638","article-title":"Clinical outcomes of digital cholangioscopy-guided procedures for the diagnosis of biliary strictures and treatment of difficult bile duct stones: a single-center large cohort 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Thosani","year":"2016","journal-title":"Endoscopy"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1007\/s00464-018-6141-0","article-title":"Diagnostic and therapeutic single-operator cholangiopancreatoscopy with SpyGlass DS: results of a multicenter retrospective cohort study","volume":"32","author":"F Turowski","year":"2018","journal-title":"Surg Endosc"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1111\/j.1572-0241.2007.01279.x","article-title":"Incidence rates of post-ERCP complications: a systematic survey of prospective studies","volume":"102","author":"A Andriulli","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.hbpd.2018.01.002","article-title":"Risk factor analysis of post-ERCP cholangitis: A single-center experience","volume":"17","author":"M Chen","year":"2018","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1001\/jamasurg.2013.1221","article-title":"The Swedish Registry of Gallstone Surgery and Endoscopic Retrograde Cholangiopancreatography (GallRiks): A Nationwide Registry for Quality Assurance of Gallstone Surgery","volume":"148","author":"L Enochsson","year":"2013","journal-title":"JAMA Surg"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1093\/ije\/dyw341","article-title":"Robust causal inference using directed acyclic graphs: the R package \u201edagitty\u201c","volume":"45","author":"J Textor","year":"2016","journal-title":"Int J Epidemiol"}],"container-title":["Endoscopy International 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