{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:55:48Z","timestamp":1783421748453,"version":"3.54.6"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["NIH R00HD086304"],"award-info":[{"award-number":["NIH R00HD086304"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["P2CHD042849"],"award-info":[{"award-number":["P2CHD042849"]}]},{"name":"Kaiser Permanente Northern California Community Benefit Grant"},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["R01DK118455"],"award-info":[{"award-number":["R01DK118455"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>\n            Objective\u2003The safety of weight loss and low weight gain during pregnancy remains unclear. To determine how different patterns of gestational weight gain (GWG), including weight loss, stability, and low GWG relate to perinatal outcomes by prepregnancy obesity class.<\/jats:p><jats:p>\n            Study Design\u2003The study population included 29,408 singleton livebirths among pregnant people with obesity from Kaiser Permanente Northern California (2008\u20132013). Clinically measured GWG was grouped into meaningful categories (Adequate: reference, met 2009 National Academy of Medicine [NAM] Guidelines [5\u20139.1\u2009kg], Excessive [&gt;9.1\u2009kg], Low [1\u20134.9\u2009kg], Stable [\u00b11\u2009kg], Weight Loss [&gt;1\u2009kg]) or GWG Z-score quintiles. Modified Poisson regression was used to estimate risk of adverse outcomes, stratified by obesity class. Electronic health record data were used to define outcomes, including cesarean delivery, preterm birth, admission to the neonatal intensive care unit, small- and large-for-gestational age infants.<\/jats:p><jats:p>\n            Results\u2003Prevalence of weight stability and weight loss was 3.8 and 3.4%, respectively. Compared with those who gained within NAM, increased risk of small-for-gestational age was observed among those with weight loss among obesity class I (Risk Ratio (RR): 1.57, 95% confidence interval [CI]: 1.12, 2.19), obesity class II (RR: 2.18, 95% CI: 1.52, 3.13), and obesity class III (RR: 1.72, 95% CI: 1.21, 2.45). Weight loss was associated with a decreased risk of cesarean delivery among obesity class III, compared with NAM.<\/jats:p><jats:p>\n            Conclusion\u2003Weight loss during pregnancy is associated with increased risk of small-for-gestational age among all obesity classes, but not other adverse perinatal outcomes and may reduce risk of cesarean delivery. Low weight gain and weight stability are not associated with risk of adverse outcomes among those with class III obesity. GWG guidelines may need to vary by obesity class.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2211-4945","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T01:20:47Z","timestamp":1700097647000},"page":"1577-1585","source":"Crossref","is-referenced-by-count":3,"title":["Weight Loss, Stability, and Low Weight Gain during Pregnancy among Individuals with Obesity: Associations with Adverse Perinatal Outcomes: An Observational Study"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9574-6109","authenticated-orcid":false,"given":"Elizabeth M.","family":"Widen","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, University of Texas at Austin, Austin, Texas"},{"name":"Department of Women's Health, Dell Medical School, University of Texas at Austin, Austin, Texas"},{"name":"Department of Pediatrics, Dell Medical School, University of Texas at Austin, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, University of Texas at Austin, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0132-2194","authenticated-orcid":false,"given":"Lorie","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Women's Health, Dell Medical School, University of Texas at Austin, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Cahill","sequence":"additional","affiliation":[{"name":"Department of Women's Health, Dell Medical School, University of Texas at Austin, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimie N.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, University of Texas at Austin, Austin, Texas"},{"name":"Department of Pediatrics, Dell Medical School, University of Texas at Austin, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saralyn F.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, University of Texas at Austin, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel R.","family":"Rickman","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, University of Texas at Austin, Austin, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique M.","family":"Hedderson","sequence":"additional","affiliation":[{"name":"Division of Research, Kaiser Permanente Northern California, Oakland, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,12,23]]},"reference":[{"key":"ref1","volume-title":"Increases in prepregnancy obesity: United States, 2016\u20132019","author":"A K Driscoll","year":"2020"},{"issue":"168","key":"ref2","first-page":"1","article-title":"Outcomes of maternal weight gain","author":"M Viswanathan","year":"2008","journal-title":"Evid Rep Technol Assess (Full 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