{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:17Z","timestamp":1740126857263,"version":"3.37.3"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"James R. and Jo Scott Research Chair Endowment"},{"name":"H.A. and Edna Benning Presidential Chair Endowment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Background\u2003Coronavirus disease 2019 (COVID-19) is associated with coagulation abnormalities and increased risk for venous and arterial thrombi. This study aimed to evaluate D-dimer levels and lupus anticoagulant (LAC) positivity in pregnant individuals with and without Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.<\/jats:p><jats:p>\n            Study Design\u2003This was a prospective cohort study of pregnant individuals delivering at a single academic institution from April 2020 to March 2022. Individuals with a positive SARS-CoV-2 result during pregnancy were compared with a convenience sample of those without a positive SARS-CoV-2 result. For individuals with SARS-CoV-2 infection, severity was assessed based on the National Institutes of Health classification system. The primary outcome was D-dimer level measured during delivery admission. The secondary outcomes were LAC positivity and thromboembolic events. Outcomes were compared between individuals with and without a positive SARS-CoV-2 result, and further by disease severity.<\/jats:p><jats:p>\n            Results\u2003Of 98 participants, 77 (78.6%) were SARS-CoV-2 positive during pregnancy. Among individuals with SARS-CoV-2 infection, severity was asymptomatic in 20 (26.0%), mild in 13 (16.9%), moderate in 4 (5.2%), severe in 38 (49.4%), and critical in 2 (2.6%). The D-dimer concentration at delivery did not significantly differ between those with a SARS-CoV-2 positive result compared with those without (mean 2.03 \u00b5g\/mL [95% confidence interval {CI} 1.72\u20132.40] vs. 2.37 \u00b5g\/mL [95% CI 1.65\u20133.40]; p\u2009=\u20090.43). Three individuals (4%) with SARS-CoV-2 infection and none (0%) without infection were LAC positive (p\u2009=\u20090.59). There were no clinically apparent thromboses in either group. D-dimer concentrations and LAC positive results did not differ by COVID-19 severity.<\/jats:p><jats:p>\n            Conclusion\u2003Thrombotic markers did not differ in pregnant individuals by SARS-CoV-2 infection; however, high rates of LAC positivity were detected.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2211-5052","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T01:20:47Z","timestamp":1700097647000},"page":"e3202-e3209","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Thrombotic Markers in Pregnant Patients with and without SARS-CoV-2 Infection"],"prefix":"10.1055","volume":"41","author":[{"given":"Ann M.","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, University of Utah Health, Salt Lake City, Utah"},{"name":"Department of Obstetrics & Gynecology, Intermountain Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda A.","family":"Allshouse","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, University of Utah Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley E.","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Oregon Health and Science University, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Con","family":"Yost","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, University of Utah Health, Salt Lake City, Utah"},{"name":"Molecular Medicine Program, Molecular Medicine Program, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torri D.","family":"Metz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, University of Utah Health, Salt Lake City, Utah"},{"name":"Department of Obstetrics & Gynecology, Intermountain Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9455-3973","authenticated-orcid":false,"given":"Michael W.","family":"Varner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, University of Utah Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, University of Utah Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Ware","family":"Branch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, University of Utah Health, Salt Lake City, Utah"},{"name":"Department of Obstetrics & Gynecology, Intermountain Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"issue":"18","key":"ref1","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"W J Guan","year":"2020","journal-title":"N Engl J Med"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"e438","DOI":"10.1016\/S2352-3026(20)30145-9","article-title":"Coagulation abnormalities and thrombosis in patients with COVID-19","volume":"7","author":"M Levi","year":"2020","journal-title":"Lancet 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