{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:52:10Z","timestamp":1763621530103,"version":"3.37.3"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim To investigate the autoimmune and genetic relationship between primary\n                    hypophysitis (PH) and celiac disease (CD).<\/jats:p><jats:p>\n          Methods The study was retrospective and patients with PH followed in our\n                    clinic between 2007 and 2022 were evaluated. Clinical, endocrinologic,\n                    pathologic, and radiologic findings and treatment modalities were assessed.\n                    Patients diagnosed with CD in the Gastroenterology outpatient clinic in\n                    2020\u20132022 were included in the study as a control group. Information\n                    such as sociodemographic data, year of diagnosis, human leukocyte antigen (HLA)\n                    DQ2\/8 information, CD-specific antibody levels, pathologic results of\n                    duodenal biopsy, treatment received, follow-up status, additional diseases,\n                    hormone use, and surgical history was obtained from patient records at PH.<\/jats:p><jats:p>In patients diagnosed with PH, a duodenal biopsy was obtained, and the tissue was\n                    examined for CD by experienced pathologists. Anti-pituitary antibody (APA) and\n                    anti-arginine-vasopressin (AAVP) antibody levels of individuals with PH and CD\n                    were measured.<\/jats:p><jats:p>\n          Results The study included 19 patients with lymphocytic hypophysitis, 30\n                    celiac patients, and 30 healthy controls. When patients diagnosed with\n                    lymphocytic hypophysitis were examined by duodenal biopsy, no evidence of CD was\n                    found in the pathologic findings. The detection rate of HLA-DQ2\/8 was\n                    80% in celiac patients and 42% in PH (p=0.044). (APA and\n                    AAVP antibodies associated with PH were tested in two separate groups of\n                    patients and in the control group. APA and anti-arginine vasopressin (AAVP)\n                    levels in PH, CD and healthy controls, respectively M [IQR]: 542\n                    [178\u2013607];164 [125\u2013243]; 82 [74\u2013107] ng\/dL\n                    (p=0.001), 174 [52\u2013218]; 60 [47\u201382]; 59 [48\u201376]\n                    ng\/dL (p=0.008) were detected. The presence of an\n                    HLA-DQ2\/8 haplotype correlates with posterior hypophysitis and\n                    panhypophysitis (r=0.598, p=0.04 and r=0.657,\n                    p=0.02, respectively).<\/jats:p><jats:p>\n          Conclusion Although patients with PH were found to have significant levels\n                    of HLA-DQ2\/8, no CD was found in the tissue. Higher levels of pituitary\n                    antibodies were detected in celiac patients compared with healthy controls, but\n                    no hypophysitis clinic was observed at follow-up. Although these findings\n                    suggest that the two diseases may share a common genetic and autoimmune basis,\n                    the development of the disease may be partially explained by exposure to\n                    environmental factors.<\/jats:p>","DOI":"10.1055\/a-2213-4375","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:27:51Z","timestamp":1700267271000},"page":"33-38","source":"Crossref","is-referenced-by-count":1,"title":["Is There A Connection Between Primary Hypophysitis and Celiac\n                    Disease?"],"prefix":"10.1055","volume":"132","author":[{"given":"Zehra","family":"Kara","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011f\u00e7e","family":"E\u015fkazan","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Gastroenterology and Hepatology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Durcan","sequence":"additional","affiliation":[{"name":"Ba\u011fc\u0131lar Training and Research Hospital, Department of\n                    Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Sulu","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Numan","family":"Demir","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhat","family":"Uysal","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hande Mefkure","family":"\u00d6zkaya","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Organ Transplantation, HLA Laboratory, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali \u0130brahim","family":"Hatemi","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Gastroenterology and Hepatology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim Murat","family":"Bolay\u0131rl\u0131","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Biochemistry, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-140X","authenticated-orcid":false,"given":"P\u0131nar","family":"Kad\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department\n                    of Endocrinology, Metabolism, and Diabetes, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.eprac.2022.06.009","article-title":"Hypophysitis","volume":"28","author":"D Donegan","year":"2022","journal-title":"Endocr Pract"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1210\/clinem\/dgab672","article-title":"Hypophysitis, the growing spectrum of a 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Yasuda","year":"2018","journal-title":"J Pathol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"260","DOI":"10.5603\/EP.a2019.0015","article-title":"Hypophysitis \u2013 new insights into diagnosis and treatment","volume":"70","author":"L Kluczy\u0144ski","year":"2019","journal-title":"Endokrynol Pol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"101276","DOI":"10.1016\/j.beem.2019.04.010","article-title":"New causes of hypophysitis","volume":"33","author":"KC J Yuen","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"104076","DOI":"10.1016\/j.lpm.2021.104076","article-title":"Hypophysitis: A comprehensive overview","volume":"50","author":"F de Vries","year":"2021","journal-title":"Presse Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/cen.13566","article-title":"human leucocyte antigens coeliac haplotypes and primary autoimmune hypophysitis\n        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