{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:12:30Z","timestamp":1768587150210,"version":"3.49.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective Long-term effects on infants of mothers with SARS-CoV-2\n                    infection during pregnancy are increasingly discussed in the literature. Besides\n                    potential neurodevelopment impairments after intrauterine SARS-CoV-2 exposure,\n                    there might be differences in the postnatal pediatric care of those children,\n                    like the timing of preventive medical examinations (PME) or vaccinations. In\n                    this first national long-term follow-up study of women included in the CRONOS\n                    registry, we describe maternal impressions of their child\u00b4s development\n                    and the prevalence of regulatory disorders, and we analyze the timing of PMEs\n                    and vaccinations.<\/jats:p><jats:p>\n          Methods 773 women who were enrolled between April 3, 2020, and August 24,\n                    2021, in the CRONOS registry were eligible to be contacted by the study\n                    coordinators and asked to fill out a web-based questionnaire.<\/jats:p><jats:p>\n          Results 110\/773 (14%) women completed the questionnaire.\n                    Their children were between the ages of 12 and 31 months (median 20 months). All\n                    mothers were satisfied with their child\u00b4s development, milestones were\n                    achieved in a timely fashion. The reported prevalence for excessive crying,\n                    sleeping, and feeding disorders was 11%, 18\u201332%, and\n                    7%, respectively. PMEs were mostly not delayed, but only 54% of\n                    infants received their first vaccination within their first 60 days of life.\n                        Discussion\u2002 In summary, our exploratory findings suggest that\n                    developmental milestones in infancy are reached in time after maternal\n                    SARS-CoV-2 infection during pregnancy. However, there are effects on the\n                    implementation of PMEs and vaccinations.<\/jats:p>","DOI":"10.1055\/a-2213-9061","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T23:33:16Z","timestamp":1707435196000},"page":"97-101","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Outcome of Neonates and Infants whose Mothers Tested\n                    Positive for SARS-CoV-2 during Pregnancy \u2013 a Pilot of the Post-CRONOS\n                    Project"],"prefix":"10.1055","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5973-3311","authenticated-orcid":false,"given":"Nadine","family":"Mand","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, University of\n                    Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, University of\n                    Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Pecks","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital of\n                    Schleswig-Holstein, Campus Kiel, Kiel, Germany"},{"name":"Department of Obstetrics, University Hospital W\u00fcrzburg,\n                    Maternal Health and Midwifery Science, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1455-1319","authenticated-orcid":false,"given":"Corinna Nora","family":"Keil","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University of Marburg,\n                    Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Backes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Munich Hospital Harlaching,\n                    Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"H\u00fctten","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Maastricht University, Maastricht,\n                    Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf Felix","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Marburg, Marburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Ruediger","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Dresden University Hospital, Dresden,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"166198","DOI":"10.1016\/j.bbadis.2021.166198","article-title":"Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and\n                    prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and\n                    Zika virus","volume":"1867","author":"C Auriti","year":"2021","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.1038\/s41467-020-17436-6","article-title":"Transplacental transmission of SARS-CoV-2 infection","volume":"11","author":"A J Vivanti","year":"2020","journal-title":"Nat Commun"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"5128","DOI":"10.1038\/s41467-020-18933-4","article-title":"Analysis of SARS-CoV-2 vertical transmission during pregnancy","volume":"11","author":"C Fenizia","year":"2020","journal-title":"Nat Commun"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1521.e1","DOI":"10.1016\/j.cmi.2021.06.016","article-title":"Congenital infection of SARS-CoV-2 in live-born neonates: a population-based\n                    descriptive study","volume":"27","author":"I Garcia-Ruiz","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2023-325835","article-title":"Vertical transmission of SARS-CoV-2 \u2013 are there differences in rates of\n                    neonatal SARS-CoV-2 infection in two classification systems?","author":"N Mand","year":"2023","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3238\/arztebl.m2022.0266","article-title":"SARS-CoV-2 infection during pregnancy","volume":"119","author":"U Pecks","year":"2022","journal-title":"Dtsch Arztebl Int"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3390\/diagnostics13020245","article-title":"Outcome of newborns with confirmed or possible SARS-CoV-2 vertical infection-a\n                    scoping review","volume":"13","author":"A Moza","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"5164","DOI":"10.1038\/s41467-020-18982-9","article-title":"Synthesis and systematic review of reported neonatal SARS-CoV-2 infections","volume":"11","author":"R Raschetti","year":"2020","journal-title":"Nat Commun"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"103523","DOI":"10.1016\/j.amjoto.2022.103523","article-title":"Can SARS-CoV-2 positive pregnant women affect the hearing of their newborns: A\n                    systematic review","volume":"43","author":"X Meng","year":"2022","journal-title":"Am J Otolaryngol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1007\/s00431-021-04319-1","article-title":"Short- and mid-term multidisciplinary outcomes of newborns exposed to SARS-CoV-2\n                    in utero or during the perinatal period: preliminary findings","volume":"181","author":"D Buonsenso","year":"2022","journal-title":"Eur J Pediatr"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e2215787","DOI":"10.1001\/jamanetworkopen.2022.15787","article-title":"Neurodevelopmental outcomes at 1 year in infants of mothers who tested positive\n                    for SARS-CoV-2 during pregnancy","volume":"5","author":"A G Edlow","year":"2022","journal-title":"JAMA Netw Open"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1186\/s12887-022-03359-2","article-title":"Neurodevelopmental outcomes of infants born to mothers with SARS-CoV-2\n                    infections during pregnancy: a national prospective study in Kuwait","volume":"22","author":"M Ayed","year":"2022","journal-title":"BMC pediatrics"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1021721","DOI":"10.3389\/fnins.2022.1021721","article-title":"SARS-CoV-2 (COVID-19) as a possible risk factor for neurodevelopmental\n                    disorders","volume":"16","author":"H Dubey","year":"2022","journal-title":"Front Neurosci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"100776","DOI":"10.1016\/j.gine.2022.100776","article-title":"Impact of the COVID-19 pandemic on maternal anxiety during pregnancy: A\n                    prevalence study","volume":"49","author":"M Berm\u00fadez-Gonz\u00e1lez","year":"2022","journal-title":"Clin Invest Ginecol Obstet"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1007\/s00103-023-03717-0","article-title":"[Early childhood mental disorders: excessive crying, sleep and feeding\n                    disorders, and interventions using the \u201cMunich model\u201d as an\n                    example]","volume":"66","author":"M Ziegler","year":"2023","journal-title":"Bundesgesundheitsblatt, Gesundheitsforschung,\n                    Gesundheitsschutz"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e2020035576","DOI":"10.1542\/peds.2020-035576","article-title":"COVID-19 and primary measles vaccination rates in a large primary care\n                    network","volume":"147","author":"S M Bode","year":"2021","journal-title":"Pediatrics"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and\n                    workflow process for providing translational research informatics support","volume":"42","author":"P A Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: Building an international community of software platform\n                    partners","volume":"95","author":"P A Harris","year":"2019","journal-title":"J Biomed Inform"},{"key":"ref19","first-page":"481","article-title":"Entwicklungsphysiologische Tabellen f\u00fcr S\u00e4uglingsalter","volume":"86","author":"T H Hellbr\u00fcgge","year":"1968","journal-title":"Fortschr Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3390\/pediatric15020034","article-title":"The assessment of psychomotor development in full-term children at 12 months of\n                    age with Munich Functional Development Diagnostics depending on the feeding\n                    method: A cross-sectional study","volume":"15","author":"G Pazera","year":"2023","journal-title":"Pediatr Rep"},{"key":"ref21","first-page":"3","article-title":"Inanspruchnahme der Fr\u00fcherkennungsuntersuchungen f\u00fcr Kinder in\n                    Deutschland \u2013 Querschnittergebnisse aus KiGGS Welle 2","author":"C Schmidtke","year":"2018","journal-title":"J Health Monit"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"101427","DOI":"10.1016\/j.siny.2023.101427","article-title":"Impact of perinatal COVID on fetal and neonatal brain and neurodevelopmental\n                    outcomes","volume":"28","author":"A C Brum","year":"2023","journal-title":"Semin Fetal Neonatal Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e0267575","DOI":"10.1371\/journal.pone.0267575","article-title":"Infants prenatally exposed to SARS-CoV-2 show the absence of fidgety movements\n                    and are at higher risk for neurological disorders: A comparative study","volume":"17","author":"V Aldrete-Cortez","year":"2022","journal-title":"PloS One"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"105694","DOI":"10.1016\/j.earlhumdev.2022.105694","article-title":"Neurodevelopment in infants with antenatal or early neonatal exposure to\n                    SARS-CoV-2","volume":"175","author":"S B Mulkey","year":"2022","journal-title":"Early human development"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13034-022-00464-z","article-title":"A cross-sectional investigation of psychosocial stress factors in German\n                    families with children aged 0\u20133 years during the COVID-19 pandemic:\n                    initial results of the CoronabaBY study","volume":"16","author":"C Buechel","year":"2022","journal-title":"Child Adolesc Psychiatry Met Health"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e2020047092","DOI":"10.1542\/peds.2020-047092","article-title":"Pediatric vaccination during the COVID-19 pandemic","volume":"148","author":"B K Ackerson","year":"2021","journal-title":"Pediatrics"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1016\/j.vaccine.2023.03.039","article-title":"First hepatitis B vaccine uptake in neonates prior to and during the COVID-19\n                    pandemic","volume":"41","author":"A M Dugovich","year":"2023","journal-title":"Vaccine"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"4081","DOI":"10.1016\/j.vaccine.2023.05.045","article-title":"Did the change of the vaccination schedule effect pneumococcal conjugate\n                    vaccination compliance and adherence of premature and mature born infants in\n                    Germany? Answers from a claims database analysis","volume":"41","author":"K Schley","year":"2023","journal-title":"Vaccine"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2213-9061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:10:16Z","timestamp":1730823016000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2213-9061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":28,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,2,8]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2213-9061","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]}}}