{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:25:51Z","timestamp":1730870751133,"version":"3.28.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Rationale Multiple-breath washout (MBW)-derived lung clearance index (LCI)\n                    detects lung disease in children with cystic fibrosis (CF). Correction of a\n                    cross-talk error in the software of the MBW device Exhalyzer D in a new software\n                    version has generated significant interest regarding its impact on previous MBW\n                    findings. Since LCI and chest magnetic resonance imaging (MRI) correlated before\n                    in CF children, this study aims to reassess previous MBW data after\n                    correction.<\/jats:p><jats:p>\n          Patients\/Methods Reanalysis of the main findings from a previously\n                    published study comparing MBW and MRI in a pediatric CF cohort by reassessment\n                    of nitrogen (N2) MBW of 61 stable children with CF, 75 age-matched\n                    healthy controls (HC), and 15 CF children with pulmonary exacerbation (PEx) in\n                    the corrected software version.<\/jats:p><jats:p>\n          Results The corrected LCI (N2LCIcor) decreased in\n                    the entire cohort (\u221217.0 (11.2)%), HC (\u22128.5\n                    (8.2)%), stable CF children (\u221222.2 (11.1)%), and within\n                    the PEx group at baseline, at PEx and after antibiotic therapy (\u221221.5\n                    (7.3)%; \u221222.5 (6.1)%; \u221221.4 (6.6)%; all\n                    P&lt;0.01). N2LCIcor and\n                        N2LCIpre correlated with chest MRI scores in stable CF\n                    (r=0.70 to 0.84; all P&lt;0.01) without a significant difference\n                    between N2LCIcor and N2LCIpre.\n                    Change in LCI from baseline to PEx and from PEx to after therapy decreased from\n                        N2LCIpre to N2LCIcor, but these\n                    changes remained significant (all P=0.001).<\/jats:p><jats:p>\n          Discussion\/Conclusions Our results indicate that\n                        N2LCIcor is significantly lower than\n                        N2LCIpre, but key results published in the original\n                    study demonstrating N2MBW and MRI as complementary methods for\n                    clinical surveillance in children with CF remain unaffected.<\/jats:p>","DOI":"10.1055\/a-2214-7217","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T23:48:17Z","timestamp":1702943297000},"page":"106-115","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Reanalysis of Nitrogen Multiple-Breath Washout on its\n                    Relationship with Chest Magnetic Resonance Imaging Findings in Clinically Stable\n                    and Pulmonary Exacerbated Children with Cystic Fibrosis"],"prefix":"10.1055","volume":"236","author":[{"given":"Maria","family":"Mei\u00dfner","sequence":"additional","affiliation":[{"name":"Dept. of Pediatric Respiratory Medicine, Immunology and Critical Care\n                    Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Steinke","sequence":"additional","affiliation":[{"name":"Dept. of Pediatric Respiratory Medicine, Immunology and Critical Care\n                    Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin,\n                    Germany"},{"name":"associated partner site, German Center for Lung Research (DZL), Berlin,\n                    Germany"},{"name":"Berlin Institute of Health (BIH) at Charit\u00e9, Berlin Institute\n                    of Health (BIH) at Charit\u00e9, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Oliver","family":"Wielp\u00fctz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Heidelberg\n                    University Hospital, Heidelberg, Germany"},{"name":"Translational Lung Research Center (TLRC), German Center for Lung\n                    Research (DZL), Heidelberg, Germany"},{"name":"Department of Diagnostic and Interventional Radiology with Nuclear\n                    Medicine, Thoraxklinik at University of Heidelberg, Heidelberg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Joachim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Pulmonology and Allergy\n                    and Cystic Fibrosis Center, University of Heidelberg, Heidelberg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Sommerburg","sequence":"additional","affiliation":[{"name":"Translational Lung Research Center (TLRC), German Center for Lung\n                    Research (DZL), Heidelberg, Germany"},{"name":"Department of Pediatrics, Division of Pediatric Pulmonology and Allergy\n                    and Cystic Fibrosis Center, University of Heidelberg, Heidelberg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Alexander","family":"Mall","sequence":"additional","affiliation":[{"name":"Dept. of Pediatric Respiratory Medicine, Immunology and Critical Care\n                    Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin,\n                    Germany"},{"name":"associated partner site, German Center for Lung Research (DZL), Berlin,\n                    Germany"},{"name":"Berlin Institute of Health (BIH) at Charit\u00e9, Berlin Institute\n                    of Health (BIH) at Charit\u00e9, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Stahl","sequence":"additional","affiliation":[{"name":"Dept. of Pediatric Respiratory Medicine, Immunology and Critical Care\n                    Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin,\n                    Germany"},{"name":"associated partner site, German Center for Lung Research (DZL), Berlin,\n                    Germany"},{"name":"Berlin Institute of Health (BIH) at Charit\u00e9, Berlin Institute\n                    of Health (BIH) at Charit\u00e9, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/s2213-2600(19)30337-6","article-title":"The future of cystic fibrosis care: a global perspective","volume":"8","author":"S C Bell","year":"2020","journal-title":"Lancet Respir Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1183\/09031936.00228013","article-title":"CFTR: cystic fibrosis and beyond","volume":"44","author":"M A Mall","year":"2014","journal-title":"Eur Respir J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1159\/000357075","article-title":"Multiple breath washout is feasible in the clinical setting and detects abnormal\n                    lung function in infants and young children with cystic fibrosis","volume":"87","author":"M Stahl","year":"2014","journal-title":"Respiration"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1183\/09031936.00069712","article-title":"Consensus statement for inert gas washout measurement using multiple- and\n                    single- breath tests","volume":"41","author":"P D Robinson","year":"2013","journal-title":"Eur Respir J"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00408-2020","article-title":"Multicentre feasibility of multiple-breath washout in preschool children with\n                    cystic fibrosis and other lung diseases","volume":"6","author":"M Stahl","year":"2020","journal-title":"ERJ Open Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1164\/rccm.201807-1203OC","article-title":"Preventive Inhalation of Hypertonic Saline in Infants with Cystic Fibrosis\n                    (PRESIS). A Randomized, Double-Blind, Controlled Study","volume":"199","author":"M Stahl","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1513\/AnnalsATS.201905-375OC","article-title":"Comparison of Multiple Breath Washout and Spirometry in Children with Primary\n                    Ciliary Dyskinesia and Cystic Fibrosis and Healthy Controls","volume":"17","author":"B Kinghorn","year":"2020","journal-title":"Ann Am Thorac Soc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1164\/rccm.201610-2158OC","article-title":"Progression of Lung Disease in Preschool Patients with Cystic Fibrosis","volume":"195","author":"S Stanojevic","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1164\/rccm.201604-0893OC","article-title":"Comparison of Lung Clearance Index and Magnetic Resonance Imaging for Assessment\n         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and ventilation inhomogeneity in\n                    children with cystic fibrosis pulmonary exacerbations","volume":"50","author":"H Grasemann","year":"2017","journal-title":"Eur Respir J"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02188-2018","article-title":"Hyperpolarised (129)Xe magnetic resonance imaging to monitor treatment response\n                    in children with cystic fibrosis","volume":"53","author":"J H Rayment","year":"2019","journal-title":"Eur Respir J"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.jcf.2018.05.003","article-title":"Multicentre standardisation of chest MRI as radiation-free outcome measure of\n                    lung disease in young children with cystic fibrosis","volume":"17","author":"M O Wielp\u00fctz","year":"2018","journal-title":"J Cyst Fibros"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1164\/rccm.201309-1659OC","article-title":"Magnetic resonance imaging detects changes in structure and perfusion, and\n                    response to therapy in early cystic fibrosis lung disease","volume":"189","author":"M O Wielp\u00fctz","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e0157177","DOI":"10.1371\/journal.pone.0157177","article-title":"Characterizing Lung Disease in Cystic Fibrosis with Magnetic Resonance Imaging\n                    and Airway Physiology","volume":"11","author":"R J Theilmann","year":"2016","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1152\/japplphysiol.00338.2021","article-title":"Correction of sensor crosstalk error in Exhalyzer D multiple-breath washout\n                    device significantly impacts outcomes in children with cystic fibrosis","volume":"131","author":"F Wyler","year":"2021","journal-title":"Journal of applied physiology (Bethesda, Md : 1985)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e208","DOI":"10.1016\/j.jcf.2022.02.013","article-title":"Impact of Spiroware re-analysis method on multiple-breath washout outcomes in\n                    children with cystic fibrosis","volume":"21","author":"M A Oestreich","year":"2022","journal-title":"J Cyst Fibros"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e204","DOI":"10.1016\/j.jcf.2021.08.033","article-title":"Impact of cross-sensitivity error correction on representative nitrogen-based\n                    multiple breath washout data from clinical trials","volume":"21","author":"P D Robinson","year":"2022","journal-title":"J Cyst Fibros"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/j.ejrad.2011.02.045","article-title":"Morphologic and functional scoring of cystic fibrosis lung disease using\n                    MRI","volume":"81","author":"M Eichinger","year":"2012","journal-title":"Eur J 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fibrosis","volume":"58","author":"B S Frauchiger","year":"2021","journal-title":"Eur Respir J"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1136\/thx.2011.161117","article-title":"Exacerbation frequency and clinical outcomes in adult patients with cystic\n                    fibrosis","volume":"66","author":"K de Boer","year":"2011","journal-title":"Thorax"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1183\/09031936.00159111","article-title":"Effect of pulmonary exacerbations on long-term lung function decline in cystic\n                    fibrosis","volume":"40","author":"V Waters","year":"2012","journal-title":"Eur Respir J"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1164\/rccm.201407-1277OC","article-title":"Early respiratory infection is associated with reduced spirometry in children\n                    with cystic fibrosis","volume":"190","author":"K A Ramsey","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1002\/ppul.26136","article-title":"Pulmonary exacerbations, airway pathogens, and long-term course of lung\n                    clearance index in children and young adults with cystic fibrosis","volume":"57","author":"E Hatziagorou","year":"2022","journal-title":"Pediatr Pulmonol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jcf.2020.07.023","article-title":"A phase 3, double-blind, parallel-group study to evaluate the efficacy and\n                    safety of tezacaftor in combination with ivacaftor in participants 6 through 11\n                    years of age with cystic fibrosis homozygous for F508del or heterozygous for the\n                    F508del-CFTR mutation and a residual function mutation","volume":"20","author":"J C Davies","year":"2021","journal-title":"J Cyst Fibros"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1136\/thoraxjnl-2021-218347","article-title":"Evaluation of clinically relevant changes in the lung clearance index in\n                    children with cystic fibrosis and healthy controls","volume":"78","author":"L Perrem","year":"2023","journal-title":"Thorax"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2214-7217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:22:50Z","timestamp":1730809370000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2214-7217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,18]]},"references-count":32,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,2,22]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2214-7217","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"type":"print","value":"0300-8630"},{"type":"electronic","value":"1439-3824"}],"subject":[],"published":{"date-parts":[[2023,12,18]]}}}