{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:32:41Z","timestamp":1740126761467,"version":"3.37.3"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n     Der Artikel gibt einen geschichtlichen \u00dcberblick \u00fcber die in den letzten beiden Jahrhunderten erfolgten Entwicklungen zum Verst\u00e4ndnis des Atemrhythmus und seiner Kontrollmechanismen. Im 19. Jahrhundert wurde erstmalig eine Struktur in der Medulla oblongata als \u201eKnoten des Lebens\u201c beschrieben. 1743 entdeckte Taube das Karotisk\u00f6rperchen, 1927 hat der Spanier de Castro dessen Morphologie und Innervation beschrieben. Erst Vater und Sohn Heymans haben die physiologische und pharmakologische Bedeutung des Karotis- und Aortenk\u00f6rperchens erkannt. Heute wissen wir, dass die Generierung und Kontrolle der Atmung durch ein komplexes neuronales Netzwerk im Hirnstamm erfolgt. Chemo-, Mechano- und Propriorezeptoren vermitteln Informationen aus Blut, Atemwegen und Muskeln in das respiratorische Netzwerk. Das Atemzentrum integriert die von den Rezeptoren, dem autonomen Nervensystem, dem Herz-Kreislauf-System sowie den willentlich vom zerebralen Kortex eingehenden Informationen und bemisst den Grad der respiratorischen Aktivierung von Motoneuronen und atmungsrelevanter Muskulatur.\n    <\/jats:p>","DOI":"10.1055\/a-2215-2937","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:16:01Z","timestamp":1702599361000},"page":"244-249","source":"Crossref","is-referenced-by-count":0,"title":["Die Suche nach dem \u201eKnoten des Lebens\u201c \u2013 die Atemregulation"],"prefix":"10.1055","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4680-3282","authenticated-orcid":false,"given":"Ulrich","family":"Koehler","sequence":"additional","affiliation":[{"name":"Pneumologie, Philipps-Universit\u00e4t Marburg, Marburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikail Aykut","family":"Degerli","sequence":"additional","affiliation":[{"name":"Pneumologie, Philipps-Universit\u00e4t Marburg, Marburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Conradt","sequence":"additional","affiliation":[{"name":"Pneumologie, Philipps-Universit\u00e4t Marburg, Marburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Pneumologie, Philipps-Universit\u00e4t Marburg, Marburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Koehler","sequence":"additional","affiliation":[{"name":"Regulatory Affairs, ThoraTech GmbH, Gie\u00dfen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wulf","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Anatomie und Zellbiologie, Philipps-Universit\u00e4t Marburg, Marburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"ref1","first-page":"3","volume-title":"Ancient Medicine and the Mystery of Breathing","author":"DF Procter","year":"1995"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1113\/expphysiol.2008.043109","article-title":"To breathe or not to breathe? 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