{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:54:34Z","timestamp":1787237674369,"version":"build-2736575974"},"reference-count":58,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Granulomatose mit Polyangiitis (GPA) und mikroskopische Polyangiitis (MPA) sind zwei zur ANCA-assoziierten Vaskulitis (AAV) z\u00e4hlende Entit\u00e4ten. Beiden Erkrankungen liegt eine systemische nekrotisierende Kleingef\u00e4\u00dfvaskulitis zugrunde, die jedes Organ betreffen kann. Bei der GPA ist zus\u00e4tzlich eine in der Regel den Respirationstrakt betreffende extravaskul\u00e4re nekrotisierende granulomat\u00f6se Entz\u00fcndung vorzufinden. Das klinische Bild wird in der Mehrzahl der F\u00e4lle durch ein pulmorenales Syndrom mit alveol\u00e4rer H\u00e4morrhagie und rapid-progressiver Glomerulonephritis sowie weitere Organmanifestationen bestimmt. Bei der GPA imponiert zudem die fast regelhafte Mitbeteiligung des oberen Respirationstrakts. Die GPA ist mit Anti-Neutrophilen zytoplasmatischen Autoantik\u00f6rpern (ANCA) mit einer Spezifit\u00e4t f\u00fcr die Proteinase 3 (PR3-ANCA) und die MPA f\u00fcr Myeloperoxidase (MPO-ANCA) assoziiert. Die immunsuppressive Therapie richtet sich nach der Krankheitsaktivit\u00e4t und Schwere der Organbeteiligung.<\/jats:p>","DOI":"10.1055\/a-2217-4457","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T19:14:55Z","timestamp":1705000495000},"page":"490-499","source":"Crossref","is-referenced-by-count":3,"title":["Granulomatose mit Polyangiitis und mikroskopische Polyangiitis"],"prefix":"10.1055","volume":"103","author":[{"given":"Sebastian","family":"Klapa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University of L\u00fcbeck, L\u00fcbeck, 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