{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:22Z","timestamp":1740126802719,"version":"3.37.3"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003To evaluate the relationship between intrahepatic cholestasis of pregnancy (ICP) and coronavirus disease 2019 (COVID-19).<\/jats:p><jats:p>\n            Study Design\u2003We performed a retrospective cohort study of pregnant women undergoing induction of labor (IOL) at a single institution between May 2020 to January 2021. Primary exposure was diagnosis of intrahepatic cholestasis of pregnancy (ICP). The primary outcome was the prevalence of COVID-19 as determined by reverse-transcriptase polymerase chain reaction testing on nasopharyngeal swabs for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) on routine admission testing. Secondary outcomes were abnormal laboratory values and adverse fetal outcomes. Logistic regression with log link analysis was performed comparing patients undergoing IOL for ICP compared with IOL for all other indications. The moderating effect of ethnicity was assessed by the interaction between ethnicity and ICP in a logistic regression model. The Wilcoxon rank-sum test and Fisher's exact test were performed for the secondary outcome analyses.<\/jats:p><jats:p>\n            Results\u2003Over the course of the study, 596 patients underwent IOL: 24 for ICP and 572 for other indications. The overall prevalence of COVID-19 positivity in the cohort was 5.5% (33 of 596). Those with ICP were more likely to test positive for COVID-19 compared with those with other IOL indications (29.2 vs. 4.5%, RR\u2009=\u20096.4, 95% CI: 2.8\u201312.5, p\u2009&lt;\u20090.001). All patients with ICP who tested positive for COVID-19 were Hispanic. To analyze the moderating effect of ethnicity, the results of the logistic model found the interaction between ethnicity and ICP to not be significant (p\u2009=\u20090.991). In patients with ICP, the median AST (aspartate aminotransferase) was higher than those with COVID-19 (p\u2009=\u20090.0182). There were no adverse fetal outcomes in the ICP group.<\/jats:p><jats:p>\n            Conclusion\u2003In this single-site retrospective cohort study, we demonstrated an increased prevalence of COVID-19 in those with ICP in general and among Hispanic patients specifically. Despite this difference, there was no increased risk of adverse fetal outcomes.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2217-8313","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T23:30:21Z","timestamp":1700955021000},"page":"e3286-e3292","source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["COVID-stasis of Pregnancy: An Increased Prevalence of COVID-19 in Patients with Cholestasis"],"prefix":"10.1055","volume":"41","author":[{"given":"Marissa G.","family":"Holden","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn V.","family":"Schmiech","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Martinez Telleria","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5991-0381","authenticated-orcid":false,"given":"Whitney R.","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole W.","family":"Karjane","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,12,23]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2020.11.002","article-title":"Society for Maternal-Fetal Medicine Consult Series #53: Intrahepatic cholestasis of pregnancy: Replaces Consult #13, April 2011","volume":"224","author":"R H Lee","year":"2021","journal-title":"Am J Obstet Gynecol"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/AOG.0000000000000346","article-title":"Intrahepatic cholestasis of pregnancy","volume":"124","author":"C Williamson","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"e28343","DOI":"10.1371\/journal.pone.0028343","article-title":"Fetal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy in a Northern California cohort","volume":"7","author":"M Rook","year":"2012","journal-title":"PLoS One"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/sj.jp.7211545","article-title":"The prevalence of intrahepatic cholestasis of pregnancy in a primarily Latina Los Angeles population","volume":"26","author":"R H Lee","year":"2006","journal-title":"J Perinatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejogrb.2013.12.037","article-title":"Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes","volume":"176","author":"M Martineau","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/jmf.10.2.131.135","article-title":"Ursodeoxycholic acid for the treatment of intrahepatic cholestasis of pregnancy","volume":"10","author":"S A Laifer","year":"2001","journal-title":"J Matern Fetal Med"},{"issue":"44","key":"ref7","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.15585\/mmwr.mm6944e3","article-title":"Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status\u2014United States, January 22\u2013October 3, 2020","volume":"69","author":"L D Zambrano","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jhep.2020.06.022","article-title":"Characteristics of pregnant patients with COVID-19 and liver injury","volume":"73","author":"G Deng","year":"2020","journal-title":"J Hepatol"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"E207","DOI":"10.1148\/radiol.2020201908","article-title":"Abdominal imaging findings in COVID-19: preliminary observations","volume":"297","author":"R Bhayana","year":"2020","journal-title":"Radiology"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.jhep.2020.05.002","article-title":"SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19","volume":"73","author":"Y Wang","year":"2020","journal-title":"J Hepatol"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jceh.2020.05.006","article-title":"Pathogenesis of Liver Injury in Coronavirus Disease 2019","volume":"10","author":"P Kumar","year":"2020","journal-title":"J Clin Exp Hepatol"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"S709","DOI":"10.1016\/j.ajog.2020.12.1174","article-title":"Intrahepatic cholestasis of pregnancy (IHCP) during the era of COVID-19","volume":"224","author":"M Soffer","year":"2021","journal-title":"Am J Obstet Gynecol"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1086\/426870","article-title":"Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus","volume":"191","author":"G A Farcas","year":"2005","journal-title":"J Infect Dis"},{"issue":"33","key":"ref14","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.15585\/mmwr.mm6933e1","article-title":"Disparities in incidence of COVID-19 among underrepresented racial\/ethnic groups in counties identified as hotspots during June 5\u201318, 2020 \u2014 22 States, February\u2013June 2020","volume":"69","author":"J T Moore","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2217-8313.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:48:57Z","timestamp":1730814537000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2217-8313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,25]]},"references-count":14,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2217-8313","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"type":"print","value":"0735-1631"},{"type":"electronic","value":"1098-8785"}],"subject":[],"published-other":{"date-parts":[[2023,11,25]]},"published":{"date-parts":[[2023,11,25]]}}}