{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T19:47:19Z","timestamp":1748375239123,"version":"3.28.0"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin K deficiency bleeding (VKDB) in neonates is a significant disorder that causes skin, gastrointestinal, and intracranial hemorrhaging. Early-onset VKDB occurs within 24\u2009hours of birth, and its prognosis is poor due to severe hemorrhage. The causes of early-onset VKDB include maternal intake of warfarin and anticoagulants, and maternal vitamin K deficiency. We report the case of a neonate with early-onset VKDB born to a mother with Crohn's disease. The neonate developed severe cerebellar hemorrhage on the day of birth and subsequent noncommunicating hydrocephalus requiring a ventriculoperitoneal shunt. The mother had a 14-year history of Crohn's disease and short bowel owing to intestinal resection. She was in complete remission during pregnancy according to the Crohn's Disease Activity Index. Endoscopic examination performed shortly before pregnancy revealed inflammatory findings in the residual small intestine. Her blood tests at delivery showed an elevated prothrombin induced by vitamin K deficiency or antagonist II (PIVKA-II) level of 26,900\u2009mAU\/mL. A definitive protocol to prevent early-onset VKDB in mothers with Crohn's disease complicated by a short bowel is lacking. Administering vitamin K to mothers with elevated PIVKA-II levels before delivery may help prevent early-onset VKDB.<\/jats:p>","DOI":"10.1055\/a-2219-5024","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:09:45Z","timestamp":1701302985000},"page":"e1-e6","source":"Crossref","is-referenced-by-count":2,"title":["Severe Early-Onset Vitamin K Deficiency Bleeding in a Neonate Born to a Mother with Crohn's Disease in Clinical Remission: A Case Report"],"prefix":"10.1055","volume":"14","author":[{"given":"Chiho","family":"Ikenaga","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Yokohama City University Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Uchi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Yokohama City University Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Yokohama City University Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michisato","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Yokohama City University Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Iwama","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Yokohama City University Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Ina","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Yokohama City University Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Tatsuno","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Yokohama City University Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kemmotsu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Yokohama City University Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shibasaki","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0022-3476(85)80656-9","article-title":"Vitamin K in infancy","volume":"106","author":"P A Lane","year":"1985","journal-title":"J Pediatr"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/jp.2014.64","article-title":"Early vitamin K deficiency bleeding in a neonate associated with maternal Crohn's disease","volume":"34","author":"A Ohishi","year":"2014","journal-title":"J Perinatol"},{"key":"ref3","first-page":"919","article-title":"Active Crohn disease with maternal vitamin K deficiency and fetal subdural hematoma","volume":"98","author":"M Hirose","year":"2001","journal-title":"Obstet Gynecol"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"International Organization for the Study of IBD. 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