{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:23Z","timestamp":1787004863541,"version":"build-2736575974"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["304091\/2021-9"],"award-info":[{"award-number":["304091\/2021-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2019\/15873-6,2021\/09879-1"],"award-info":[{"award-number":["2019\/15873-6,2021\/09879-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,5]]},"abstract":"Abstract<\/jats:title>\n Few studies demonstrated a percentage decrease in the estimated glomerular\n filtration rate (eGFR) at a single time and the rate of hypoaldosteronism after\n adrenalectomy for primary aldosteronism (PA). Our aim was to investigate the\n evolution of renal function and the hypoaldosteronism risk after adrenalectomy\n for PA. Aldosterone, renin, eGFR, and electrolyte levels were determined before\n and at 1 week, 1, 3 and 6 months after unilateral adrenalectomy in 94 PA\n patients (40 men and 54 women). The main outcome was the postoperative eGFR\n decline using analysis of covariance with the preoperative eGFR as a covariate.\n eGFR decreased during first postoperative week compared to 3 months before\n surgery. During the first 6 months, eGFR remained stable at similar levels to\n the first week after surgery. Age (p=0.001), aldosterone levels\n (p=0.021) and eGFR 3 months before surgery\n (p+<+0.0001) had a significant correlation with eGFR\n during first postoperative week. High aldosterone levels at diagnosis were\n correlated with decline in renal function in the univariate model\n (p=0.033). In the multivariate analysis, aldosterone levels at diagnosis\n had a tendency to be an independent predictor of renal function after surgery\n (p=0.059). Postoperative biochemical hypoaldosteronism was diagnosed in\n 48% of the cases after adrenalectomy, but prolonged hyperkalemia\n occurred in only 4 cases (4.5%). Our findings showed a decrease of eGFR\n after unilateral adrenalectomy for PA. Additionally, aldosterone levels at\n diagnosis correlated with postoperative renal function. Postoperative\n biochemical hypoaldosteronism occurred in almost half of the patients, but\n prolonged hyperkalemia with fludrocortisone replacement was less frequent.<\/jats:p>","DOI":"10.1055\/a-2221-3302","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T19:14:50Z","timestamp":1701458090000},"page":"350-357","source":"Crossref","is-referenced-by-count":5,"title":["Renal Function Evolution and Hypoaldosteronism Risk After Unilateral\n Adrenalectomy for Primary Aldosteronism"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1597-6616","authenticated-orcid":false,"given":"Nara L.","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e\n Celular LIM\/25, Divis\u00e3o de Endocrinologia e Metabologia,\n Hospital das Cl\u00ednicas, Universidade de S\u00e3o Paulo Faculdade de\n Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheo A. M.","family":"Stumpf","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e\n Celular LIM\/25, Divis\u00e3o de Endocrinologia e Metabologia,\n Hospital das Cl\u00ednicas, Universidade de S\u00e3o Paulo Faculdade de\n Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor C. M.","family":"Souza","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e\n Celular LIM\/25, Divis\u00e3o de Endocrinologia e Metabologia,\n Hospital das Cl\u00ednicas, Universidade de S\u00e3o Paulo Faculdade de\n Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Alice W.","family":"Maciel","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e\n Celular LIM\/25, Divis\u00e3o de Endocrinologia e Metabologia,\n Hospital das Cl\u00ednicas, Universidade de S\u00e3o Paulo Faculdade de\n Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo F. C.","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e\n Celular LIM\/25, Divis\u00e3o de Endocrinologia e Metabologia,\n Hospital das Cl\u00ednicas, Universidade de S\u00e3o Paulo Faculdade de\n Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Okubo","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e\n Celular LIM\/25, Divis\u00e3o de Endocrinologia e Metabologia,\n Hospital das Cl\u00ednicas, Universidade de S\u00e3o Paulo Faculdade de\n Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Srougi","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Urologia, Hospital das Cl\u00ednicas,\n Universidade de S\u00e3o Paulo Faculdade de Medicina, Sao Paulo,\n Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Y.","family":"Tanno","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Urologia, Hospital das Cl\u00ednicas,\n Universidade de S\u00e3o Paulo Faculdade de Medicina, Sao Paulo,\n Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Chambo","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Urologia, Hospital das Cl\u00ednicas,\n Universidade de S\u00e3o Paulo Faculdade de Medicina, Sao Paulo,\n Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Adelaide A.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e\n Celular LIM\/25, Divis\u00e3o de Endocrinologia e Metabologia,\n Hospital das Cl\u00ednicas, Universidade de S\u00e3o Paulo Faculdade de\n Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pio-Abreu","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Disciplina de Nefrologia, Hospital das\n Cl\u00ednicas, Universidade de S\u00e3o Paulo Faculdade de Medicina, Sao\n Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A.","family":"Bortolotto","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o\n (InCor), Universidade de S\u00e3o Paulo Faculdade de Medicina, Sao Paulo,\n Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia","family":"Latronico","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e\n Celular LIM\/25, Divis\u00e3o de Endocrinologia e Metabologia,\n Universidade de S\u00e3o Paulo Faculdade de Medicina, Sao Paulo,\n Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Candida","family":"Barisson Villares Fragoso","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal & Desenvolvimento, Laborat\u00f3rio de\n Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Divis\u00e3o\n de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Universidade de\n S\u00e3o Paulo Faculdade de Medicina, Sao Paulo, Brazil"},{"name":"Divis\u00e3o de Oncologia End\u00f3crina, Instituto do\n C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP), Universidade de\n S\u00e3o Paulo Faculdade de Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano F.","family":"Drager","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Disciplina de Nefrologia, Hospital das\n Cl\u00ednicas, Universidade de S\u00e3o Paulo Faculdade de Medicina, Sao\n Paulo, Brazil"},{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o\n (InCor), Universidade de S\u00e3o Paulo Faculdade de Medicina, Sao Paulo,\n Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice B.","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal & Desenvolvimento, Laborat\u00f3rio de\n Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Divis\u00e3o\n de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Universidade de\n S\u00e3o Paulo Faculdade de Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madson Q.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Endocrinologia Molecular e\n Celular LIM\/25, Divis\u00e3o de Endocrinologia e Metabologia,\n Hospital das Cl\u00ednicas, Universidade de S\u00e3o Paulo Faculdade de\n Medicina, Sao Paulo, Brazil"},{"name":"Divis\u00e3o de Oncologia End\u00f3crina, Instituto do\n C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP), Universidade de\n S\u00e3o Paulo Faculdade de Medicina, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJMra1201534","article-title":"Measuring the global burden of disease","volume":"369","author":"CJ L Murray","year":"2013","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and\n treatment: an endocrine society clinical practice guideline","volume":"101","author":"J W Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/ajh\/hpac079","article-title":"Primary aldosteronism: state-of-the-art review","volume":"35","author":"A Vaidya","year":"2022","journal-title":"Am J Hypertens"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1590\/2359-3997000000274","article-title":"Diagnosis and management of primary aldosteronism","volume":"61","author":"LA P Vilela","year":"2017","journal-title":"Arch Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.7326\/M20-0065","article-title":"The unrecognized prevalence of primary aldosteronism","volume":"173","author":"J M Brown","year":"2020","journal-title":"Ann Intern Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1210\/jc.2019-00531","article-title":"KCNJ5 somatic mutation is a predictor of hypertension remission after\n adrenalectomy for unilateral primary aldosteronism","volume":"104","author":"LA P Vilela","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1210\/jc.2009-1763","article-title":"Improved quality of life, blood pressure, and biochemical status following\n laparoscopic adrenalectomy for unilateral primary aldosteronism","volume":"95","author":"N Sukor","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref8","first-page":"62","article-title":"Long-term control of arterial hypertension and regression of left ventricular\n hypertrophy with treatment of primary aldosteronism","volume":"62","author":"G P Rossi","year":"2013","journal-title":"Hypertens Dallas Tex 1979"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared\n with essential hypertension: a systematic review and meta-analysis","volume":"6","author":"S Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref10","first-page":"530","article-title":"Prevalence of cardiovascular disease and its risk factors in primary\n aldosteronism: a multicenter study in Japan","volume":"71","author":"Y Ohno","year":"2018","journal-title":"Hypertens Dallas Tex 1979"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1046\/j.1523-1755.2003.00929.x","article-title":"Aldosterone\/salt induces renal inflammation and fibrosis in hypertensive\n rats","volume":"63","author":"E R Blasi","year":"2003","journal-title":"Kidney Int"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1210\/jc.2008-1851","article-title":"Risk factors associated with a low glomerular filtration rate in primary\n aldosteronism","volume":"94","author":"M Reincke","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1530\/EJE-19-0047","article-title":"Renal impairment is closely associated with plasma aldosterone concentration in\n patients with primary aldosteronism","volume":"181","author":"A Kawashima","year":"2019","journal-title":"Eur J Endocrinol"},{"key":"ref14","first-page":"831","article-title":"Factors associated with renal function change after unilateral adrenalectomy in\n patients with primary aldosteronism","volume":"29","author":"Y-C Lu","year":"2022","journal-title":"Int J Urol Off J Jpn Urol Assoc"},{"key":"ref15","first-page":"229","article-title":"Assessment of postoperative renal function after adrenalectomy in patients with\n primary aldosteronism","volume":"26","author":"T Onohara","year":"2019","journal-title":"Int J Urol Off J Jpn Urol Assoc"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/jch.12914","article-title":"Effects of Treating Primary Aldosteronism on Renal Function","volume":"19","author":"B J Kramers","year":"2017","journal-title":"J Clin Hypertens Greenwich Conn"},{"key":"ref17","first-page":"630","article-title":"Association between acute fall in estimated glomerular filtration rate after\n treatment for primary aldosteronism and long-term decline in renal function","volume":"74","author":"H Kobayashi","year":"2019","journal-title":"Hypertens Dallas Tex 1979"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1177\/000313481708300624","article-title":"Considering postoperative functional hypoaldosteronism after unilateral\n adrenalectomy","volume":"83","author":"L F Starker","year":"2017","journal-title":"Am Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1210\/jc.2012-2234","article-title":"Prolonged zona glomerulosa insufficiency causing hyperkalemia in primary\n aldosteronism after adrenalectomy","volume":"97","author":"E Fischer","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1530\/EJE-15-0074","article-title":"Clinical risk factors of postoperative hyperkalemia after adrenalectomy in\n patients with aldosterone-producing adenoma","volume":"172","author":"K S Park","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1507\/endocrj.EJ23-0174","article-title":"Prolonged postoperative hypoaldosteronism related to hyperkalemia in patients\n with aldosterone-producing adenoma","volume":"70","author":"N Wada","year":"2023","journal-title":"Endocr J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/00365510802141140","article-title":"Reliability of GFR formulas based on serum creatinine, with special reference to\n the MDRD Study equation","volume":"241","author":"J Coresh","year":"2008","journal-title":"Scand J Clin Lab Investig Suppl"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1210\/clinem\/dgac679","article-title":"Intra-individual variability of serum aldosterone and implications for primary\n aldosteronism Screening","volume":"108","author":"AA W Maciel","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"bvad147","DOI":"10.1210\/jendso\/bvad147","article-title":"Efficacy of oral furosemide test for primary aldosteronism diagnosis","volume":"8","author":"T C Freitas","year":"2023","journal-title":"J Endocr Soc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1210\/jc.2013-4146","article-title":"Accuracy of adrenal imaging and adrenal venous sampling in predicting surgical\n cure of primary aldosteronism","volume":"99","author":"V Lim","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/ERC-20-0384","article-title":"Phosphodiesterase 2A and 3B variants are associated with primary\n aldosteronism","volume":"28","author":"M Rassi-Cruz","year":"2021","journal-title":"Endocr Relat Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH guidelines for the management of arterial hypertension","volume":"39","author":"B Williams","year":"2018","journal-title":"Eur Heart J"},{"key":"ref28","first-page":"7","article-title":"7th Brazilian guideline of arterial hypertension: Chapter 2 - diagnosis and\n classification","volume":"107","author":"MV B Malachias","year":"2016","journal-title":"Arq Bras Cardiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: an\n international consensus on outcome measures and analysis of remission rates in\n an international cohort","volume":"5","author":"T A Williams","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2288-1-6","article-title":"The use of percentage change from baseline as an outcome in a controlled trial\n is statistically inefficient: a simulation study","volume":"1","author":"A J Vickers","year":"2001","journal-title":"BMC Med Res Methodol"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.1201\/9780429492259","volume-title":"Flexible imputation of missing data, Second Edition. 2nd ed","author":"S van Buuren","year":"2018"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1055\/a-1778-4002","article-title":"Early renin recovery after adrenalectomy in aldosterone-producing adenomas: a\n prospective study","volume":"54","author":"L M Mermejo","year":"2022","journal-title":"Horm Metab Res"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2221-3302.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T05:41:08Z","timestamp":1730785268000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2221-3302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":32,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2024,5,2]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2221-3302","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12,1]]},"published":{"date-parts":[[2023,12,1]]}}}