{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:23Z","timestamp":1787004863554,"version":"build-2736575974"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"07\/08","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["448289381"],"award-info":[{"award-number":["448289381"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tropaeolum majus (garden nasturtium) is a plant with relevance in phytomedicine, appreciated not only for its pharmaceutical activities, but also for its beautiful leaves and flowers. Here, we investigated the phytochemical composition of senescent nasturtium leaves. Indeed, we identified yellow chlorophyll catabolites, also termed phylloxanthobilins, which we show to contribute to the bright yellow color of the leaves in the autumn season. Moreover, we isolated and characterized the phylloxanthobilins from T. majus, and report the identification of a pyro-phylloxanthobilin, so far only accessible by chemical synthesis. We show that the phylloxanthobilins contribute to bioactivities of T. majus by displaying strong anti-oxidative effects in vitro and in cellulo, and anti-inflammatory effects as assessed by COX-1 and COX-2 enzyme inhibition, similar to other bioactive ingredients of T. majus, isoquercitrin, and chlorogenic acid.\n          Hence, phylloxanthobilins could play a role in the efficacy of T. majus in the treatment of urinary tract infections, an established indication of T. majus. With the results shown in this study, we aid in the completion of the phytochemical profile of T. majus by identifying additional bioactive natural products as relevant components of this medicinal plant.<\/jats:p>","DOI":"10.1055\/a-2225-8314","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T18:34:57Z","timestamp":1717698897000},"page":"641-650","source":"Crossref","is-referenced-by-count":10,"title":["Structural Characterization, and Antioxidative and Anti-inflammatory Activities of Phylloxanthobilins in Tropaeolum majus, a Plant with Relevance in Phytomedicine"],"prefix":"10.1055","volume":"90","author":[{"given":"Patricia","family":"Frei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilian University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Nadegger","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika M.","family":"Vollmar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilian University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3415-3673","authenticated-orcid":false,"given":"Simone","family":"Moser","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilian University of Munich, Germany"},{"name":"Institute of Pharmacy, Department of Pharmacognosy, University of Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e2100061","DOI":"10.1002\/ardp.202100061","article-title":"Phyllobilins as a challenging diverse natural product class: Exploration of pharmacological activities","volume":"354","author":"P Wang","year":"2021","journal-title":"Arch Pharm"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"6227","DOI":"10.1039\/C4CS00079J","article-title":"Phyllobilins \u2013 The abundant bilin-type tetrapyrrolic catabolites of the green plant pigment chlorophyll","volume":"43","author":"B Kr\u00e4utler","year":"2014","journal-title":"Chem Soc Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1039\/b813558d","article-title":"A yellow chlorophyll catabolite is a pigment of the fall colours","volume":"7","author":"S Moser","year":"2008","journal-title":"Photochem Photobiol 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