{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:29:25Z","timestamp":1730870965751,"version":"3.28.0"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Gegenstand und Ziel In dieser retrospektiven Studie wurden Patientenakten\n                    von mit Cumarinderivaten vergifteten Hunden ausgewertet, um das klinische Bild\n                    genauer zu charakterisieren.<\/jats:p><jats:p>\n          Material und Methoden Dazu erfolgte eine retrospektive Analyse der Daten\n                    von 52 Hunden mit h\u00e4mostaseologisch nachgewiesener Intoxikation mit\n                    Cumarinderivaten, die in der Klinik f\u00fcr Kleintiere station\u00e4r\n                    zwischen September 2011 und Oktober 2018 behandelt wurden.<\/jats:p><jats:p>\n          Ergebnisse Bei nur 2 Hunden (4%) konnte eine Giftaufnahme sicher\n                    beobachtet werden. Die h\u00e4ufigsten beobachteten Symptome waren ein\n                    reduziertes Allgemeinverhalten (79%), Bl\u00e4sse der Schleimhaut\n                    (79%), Anorexie (60%) und Dyspnoe\/Tachypnoe\n                    (60%). Makroskopisch sichtbare innere und \u00e4u\u00dfere\n                    Blutungen traten hingegen seltener auf. Initial zeigte sich in allen\n                    F\u00e4llen eine hochgradig ver\u00e4nderte Prothrombinzeit sowie bei den\n                    meisten Patienten eine deutlich verl\u00e4ngerte aktivierte partielle\n                    Thromboplastinzeit. Eine An\u00e4mie lag bei 75% der Patienten vor.\n                    Alle in die Studie aufgenommenen Hunde wurden initial mit\n                    10\u2009mg\/kg Vitamin K1 intraven\u00f6s behandelt. Zur\n                    Prophylaxe einer m\u00f6glichen Unvertr\u00e4glichkeitsreaktion erfolgte\n                    eine Vorbehandlung mit 1\u2009mg\/kg Prednisolon. Kein Patient zeigte\n                    Anzeichen einer anaphylaktoiden Reaktion. Transfusionen von Vollblut oder\n                    Erythrozytenkonzentrat bekamen nur 10 der 52 Tiere; nur eines 2\n                    Erythrozytentransfusionen. 94% der Tiere konnten nach einer medianen\n                    Klinikaufenthaltsdauer von 3 Tagen (1\u20139 Tage) mit physiologischen oder\n                    ann\u00e4hernd physiologischen Gerinnungszeiten zur ambulanten Therapie nach\n                    Hause entlassen werden.<\/jats:p><jats:p>\n          Schlussfolgerung Die Cumarinintoxikation ist oft verbunden mit\n                    unspezifischen Symptomen und besitzt bei ad\u00e4quater Therapie eine gute\n                    Prognose.<\/jats:p><jats:p>\n          Klinische Relevanz Bei unklaren Erkrankungsf\u00e4llen ist immer eine\n                    Gerinnungsdiagnostik indiziert. Bei lebensbedrohlichen Notf\u00e4llen stellt\n                    die unverz\u00fcgliche intraven\u00f6se Infusion von hochdosiertem Vitamin\n                        K1 eine sehr effektive Behandlung dar und f\u00fchrt zu einem\n                    raschen Anstieg der Gerinnungsfaktoraktivit\u00e4t.<\/jats:p>","DOI":"10.1055\/a-2226-4348","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:05:27Z","timestamp":1709078727000},"page":"5-16","source":"Crossref","is-referenced-by-count":0,"title":["Vergiftung mit Cumarinderivaten beim Hund: Retrospektive Analyse\n                    klinischer und labordiagnostischer Daten"],"prefix":"10.1055","volume":"52","author":[{"given":"Anna","family":"Frommeyer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche\n                    Hochschule Hannover, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Mischke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche\n                    Hochschule Hannover, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/s0195-5616(88)50012-8","article-title":"Diagnosis and therapy of anticoagulant rodenticide intoxications","volume":"18","author":"M E Mount","year":"1988","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1939-1676.1992.tb00981.x","article-title":"Coagulopathic effects and therapy of brodifacoum toxicosis in dogs","volume":"6","author":"B J Woody","year":"1992","journal-title":"J Vet Intern Med"},{"key":"ref3","first-page":"237","article-title":"Anticoagulant rodenticide intoxication in animals - A review","volume":"32","author":"I Valchev","year":"2008","journal-title":"Turk J Vet Anim Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"436","DOI":"10.15835\/buasvmcn-vm:11480","article-title":"Epidemiological, clinical and pathological features in anticoagulant rodenticide\n                    toxicosis in dogs: 66 cases (2010\u20132015). 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