{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:26:04Z","timestamp":1773188764009,"version":"3.50.1"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heart failure is a health problem worldwide. There are some drugs for it,\n                    including digoxin, spironolactone, captopril, and valsartan, but some of these\n                    drugs can produce secondary effects, such as arrhythmia, cough, hyperkalemia,\n                    hyponatremia and hypotension. The aim of this research was to evaluate the\n                    biological activity of coumarin (2H-chromen-2-one) and its derivatives\n                    (3BrAcet-C, 3\u20134Br-Ph-C, 4-CN-7D-C, 4-Me-7-Ph-C and 6Br-3-D-C) against\n                    ischemia\/reperfusion injury as a therapeutic alternative for heart\n                    failure. In addition, the biological activity of the coumarin derivative\n                    4-Me-7-Ph-C on left ventricular pressure (LVP) was determined in the absence or\n                    presence of ouabain and nifedipine at a dose of 1\u2009nM using an isolated\n                    rat heart model. The results showed that i) the coumarin derivative\n                    4-Me-7-Ph-C significantly decreased the infarct area\n                    (p+=+0.05) compared with 3BrAcet-C,\n                    3\u20134Br-Ph-C, 4-CN-7D-C, and 6Br-3-D-C; and ii) 4-Me-7-Ph-C\n                    increased LVP in a dose-dependent manner, which effect was inhibited by\n                    nifedipine. These data suggest that coumarin 4-Me-7-Ph-C may act as a\n                        type-L calcium channel activator, so it could be a good agent to\n                    treat heart failure.<\/jats:p>","DOI":"10.1055\/a-2228-4258","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T23:43:36Z","timestamp":1705535016000},"page":"47-52","source":"Crossref","is-referenced-by-count":4,"title":["Biological Activity of a Coumarin Derivative on Heart Failure Using\n                    an Ischemia\/Reperfusion Injury Model"],"prefix":"10.1055","volume":"74","author":[{"given":"Lauro","family":"Figueroa-Valverde","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological\n                    Sciences, University Autonomous of Campeche, Campeche, Camp.,\n                    Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Rosas-Nexticapa","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Universidad Veracruzana, Unidad del Bosque Xalapa\n                    Veracruz, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Alvarez-Ramirez","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Universidad Veracruzana, Unidad del Bosque Xalapa\n                    Veracruz, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Melgarejo-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad Veracruzana, Unidad del Bosque Xalapa\n                    Veracruz, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Mateu-Armand","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Universidad Veracruzana, Unidad del Bosque Xalapa\n                    Veracruz, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Garcimarrero-Espino","sequence":"additional","affiliation":[{"name":"Faculty of Nutrition, Universidad Veracruzana, Unidad del Bosque Xalapa\n                    Veracruz, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.62480\/tjms.2022.vol14.pp168-173","article-title":"Quality of Life in Patients with Chronic Heart Failure, After Cardiac\n                    Resynchronization Therapy","volume":"14","author":"K Nizamitdinovich","year":"2022","journal-title":"Texas J Med Sci"},{"key":"ref2","first-page":"55","article-title":"Assessment of the quality of life in elderly and senile age patients with\n                    chronic heart failure","volume":"11","author":"O 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Pharmacol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/963248","article-title":"Review on natural coumarin lead compounds for their pharmacological activity.","volume":"963248","author":"K Venugopala","year":"2013","journal-title":"BioMed Res Int"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e202200476","DOI":"10.1002\/cmdc.202200476","article-title":"Synthesis and Vasorelaxant Activity of Nitrate-Coumarin Derivatives","volume":"17","author":"M Matos","year":"2022","journal-title":"ChemMedChem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.3390\/ijms20112731","article-title":"Esculetin, a coumarin derivative, prevents thrombosis: inhibitory signaling on\n                    PLC\u03b32\u2013PKC\u2013AKT activation in human platelets","volume":"20","author":"C Hsia","year":"2019","journal-title":"International J Mol 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2228-4258.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:29:36Z","timestamp":1730806176000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2228-4258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":37,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,2,12]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2228-4258","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]}}}