{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:32:48Z","timestamp":1787643168078,"version":"build-2736575974"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Spinal cord injury (SCI) with subsequent paraplegia and\/or stroke after arch repair with frozen elephant trunk (FET) remain the most devastating complications. In this study, we aim to examine the impact of different cerebral perfusion strategies on the neurological outcome comparing bilateral antegrade cerebral perfusion (bACP) and trilateral antegrade cerebral perfusion (tACP).<\/jats:p><jats:p>\n          Methods\u2003Between 2009 and 2021, 88 patients underwent total arch replacement using a hybrid prosthesis in FET technique for acute (40.4%) and chronic (59.6%) aortic pathologies. After excluding 14 patients who underwent FET with unilateral ACP the remaining 74 patients were divided into two groups. Propensity score matching was performed based on pre- and perioperative patient characteristics resulting in 22 patients in each group. The primary endpoint was a combination of major cerebral event and SCI. Secondary end point was all-cause mortality.<\/jats:p><jats:p>\n          Results\u2003Major cerebral events occurred in 9% of the patients in bACP versus 13.6% in tACP group (p\u2009=\u20090.63). No postoperative SCI was observed in patients with bACP and only one patient suffered SCI with tACP (p\u2009=\u20090.31). There was no significant difference in 30-day mortality between the two groups (22.7% in bACP vs. 13.6% in tACP; p\u2009=\u20090.43).<\/jats:p><jats:p>\n          Conclusion\u2003In patients undergoing total aortic arch repair using FET technique, both perfusion strategies (bilateral and trilateral ACP) are safe and effective. The rates of neurological complications as well as mortalities are acceptably low in both groups. Further studies with larger patient cohorts are warranted.<\/jats:p>","DOI":"10.1055\/a-2228-7189","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:16:17Z","timestamp":1702512977000},"page":"025-032","source":"Crossref","is-referenced-by-count":2,"title":["Trilateral versus Bilateral Antegrade Cerebral Perfusion in Frozen Elephant Trunk: A Propensity Score Analysis"],"prefix":"10.1055","volume":"73","author":[{"given":"Razan","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Hospital of the Goethe University Frankfurt, Frankfurt am Main, Hessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Van Linden","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Hospital of the Goethe University Frankfurt, Frankfurt am Main, Hessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hlavicka","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Hospital of the Goethe University Frankfurt, Frankfurt am Main, Hessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsaneh","family":"Karimian-Tabrizi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Hospital of the Goethe University Frankfurt, Frankfurt am Main, Hessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Ischewski","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Perfusion, Life Systems, M\u00f6nchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Walther","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Hospital of the Goethe University Frankfurt, Frankfurt am Main, Hessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Holubec","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Hospital of the Goethe University Frankfurt, Frankfurt am Main, Hessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jtcvs.2005.09.050","article-title":"Extensive deployment of the stented elephant trunk is associated with an increased risk of spinal cord injury","volume":"131","author":"J Flores","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"05","key":"ref2","first-page":"606","article-title":"Early- and medium-term results after aortic arch replacement with frozen elephant trunk techniques-a single center study","volume":"2","author":"S Leontyev","year":"2013","journal-title":"Ann Cardiothorac 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Surg"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/ejcts\/ezv150","article-title":"Impact of clinical factors and surgical techniques on early outcome of patients treated with frozen elephant trunk technique by using EVITA open stent-graft: results of a multicentre study","volume":"49","author":"S Leontyev","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"e325","DOI":"10.1093\/ejcts\/ezt374","article-title":"One-stage repair in complex multisegmental thoracic aneurysmal disease: results of a multicentre study","volume":"44","author":"C A Mestres","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1540-8191.1992.tb00790.x","article-title":"Cerebral consequences of hypothermic circulatory arrest in adults","volume":"7","author":"E B 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