{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:42Z","timestamp":1740126822879,"version":"3.37.3"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background The differentiation between latent tuberculosis infection\n                    (LTBI) and tuberculosis (TB) relies on radiological changes. Confirming the\n                    diagnosis remains a challenge because typical findings are often missing in\n                    children. This study evaluates diagnostic sensitivity, specifity and\n                    interobserver agreement on the radiological diagnosis of TB by chest-x-rays in\n                    accordance to professional specialization and work experience.<\/jats:p><jats:p>\n          Methods Chest x-rays of 120 children with proven tuberculosis infection\n                    were independently evaluated by general radiologists, paediatric radiologists\n                    and paediatric pulmonologists. Results were compared to a reference diagnosis\n                    created by group of experienced paediatric radiologists and paediatric\n                    pulmonologists. Primary endpoints were diagnostic sensitivity and specificity\n                    and interobserver variability defined as Krippendorfs alpha of thesel groups\n                    compared to the reference diagnosis.<\/jats:p><jats:p>\n          Results Of the 120 chest x-rays 33 (27,5%) were diagnosed as TB by\n                    the reference standard . Paediatric pulmonologist had the highest diagnostic\n                    sensitivity (90%) but were less specific (71%) whereas general\n                    radiologist were less sensitive (68%) but more secific (95%).\n                    The best diagnostic accuracy was achieved by pediatric radiologists with a\n                    diagnostic sensitivity of 77% and specificity 95%\n                    respectively.<\/jats:p><jats:p>\n          Conclusions We demonstrated significant interobserver variability and\n                    relevant differences in sensitivity and specificity in the radiological\n                    diagnosis of TB between the groups. Paediatric radiologists showed the best\n                    diagnostic performance. As the diagnosis of pulmonary TB has significant\n                    therapeutic consequences for children they should be routinely involved in the\n                    diagnostic process.<\/jats:p>","DOI":"10.1055\/a-2230-6958","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T23:54:30Z","timestamp":1707263670000},"page":"123-128","source":"Crossref","is-referenced-by-count":0,"title":["TB or not TB? Diagnostic Sensitivity, Specifity and Interobserver\n                    Agreement in the Radiological Diagnosis of Pulmonary Tuberculosis in\n                    Children"],"prefix":"10.1055","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4307-4232","authenticated-orcid":false,"given":"Folke","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Sektion P\u00e4diatrische Pneumologie und Allergologie,\n                    Universit\u00e4tskinderklnik UKSH, Campus L\u00fcbeck, Germany"},{"name":"Universit\u00e4tsklinik f\u00fcr Kinder- und Jugendmedizin der\n                    Ruhr Universit\u00e4t Bochum, Germany"},{"name":"ARNC (Airway Research Center North) , Deutsches Zentrum f\u00fcr\n                    Lungenforschung e V, L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Hofgrefe","sequence":"additional","affiliation":[{"name":"Radiologische Praxis Berlin, Radiologische Praxis, Berlin,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Ahrens","sequence":"additional","affiliation":[{"name":"Kinderarzthaus Uster, Kinderarztpraxis, Uster,\n                    Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Weidemann","sequence":"additional","affiliation":[{"name":"Radiology, Kinderkrankenhaus auf der Bult, Hannover,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars Daniel","family":"Berthold","sequence":"additional","affiliation":[{"name":"Radiology, Universitatsklinikum Giessen und Marburg GmbH Standort\n                    Giessen, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaus","family":"Schwerk","sequence":"additional","affiliation":[{"name":"Pediatric pulmonology and neonatology, Hannover medical school,\n                    Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"ref2","first-page":"2020","volume-title":"Bericht zur Epidemiologie der Tuberkulose in Deutschland fu\u0308r","author":"B Brodhun","year":"2021"},{"volume-title":"WHO operational handbook on tuberculosis. 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Andronikou","year":"2005","journal-title":"Pediatr Radiol"},{"key":"ref20","first-page":"e0001799","article-title":"Optimising computer aided detection to identify intra-thoracic tuberculosis on\n                    chest x-ray in South African children. PLOS Glob","volume":"3","author":"M Palmer","year":"2023","journal-title":"Public Health"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.3390\/jcm11195714","article-title":"Utility and Limits of Lung Ultrasound in Childhood Pulmonary Tuberculosis:\n                    Lessons from a Case Series and Literature Review","volume":"11","author":"R Morello","year":"2022","journal-title":"J Clin Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e289","DOI":"10.1016\/S1473-3099(20)30177-8","article-title":"Advanced imaging tools for childhood tuberculosis: potential applications and\n                    research needs","volume":"20","author":"S K Jain","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/pathogens11030327","article-title":"Towards Accurate Point-of-Care Tests for Tuberculosis in Children","volume":"11","author":"N Vaezipour","year":"2022","journal-title":"Pathogens."}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2230-6958.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:23:01Z","timestamp":1730809381000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2230-6958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":21,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,2,22]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2230-6958","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"type":"print","value":"0300-8630"},{"type":"electronic","value":"1439-3824"}],"subject":[],"published":{"date-parts":[[2024,2]]}}}