{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:45:21Z","timestamp":1786711521039,"version":"build-2736575974"},"reference-count":94,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of perturbed gastrointestinal integrity, as well as resulting\n                    systemic immune responses and gastrointestinal symptoms, otherwise known as\n                    exercised-induced gastrointestinal syndrome (EIGS), is common among individuals\n                    who partake in prolonged exercise. EIGS may cause the translocation of\n                    pathogenic material, including whole bacteria and bacterial endotoxins, from the\n                    lumen into circulation, which may progress into clinical consequences such as\n                    sepsis, and potentially subsequent fatality. However, further investigation is\n                    warranted to assess the possibility of food allergen and\/or digestive\n                    enzyme luminal to circulatory translocation in response to exercise, and the\n                    clinical consequences. Findings from this narrative literature review\n                    demonstrate evidence that whole bacteria and bacterial endotoxins translocation\n                    from the gastrointestinal lumen to systemic circulation occurs in response to\n                    exercise stress, with a greater propensity of translocation occurring with\n                    accompanying heat exposure. It has also been demonstrated that food allergens\n                    can translocate from the lumen to systemic circulation in response to exercise\n                    stress and initiate anaphylaxis. To date, no research investigating the effect\n                    of exercise on the translocation of digestive enzymes from the lumen into\n                    systemic circulation exists. It is evident that EIGS and consequential\n                    pathogenic translocation presents life-threatening clinical implications,\n                    warranting the development and implementation of effective management strategies\n                    in at-risk populations.<\/jats:p>","DOI":"10.1055\/a-2235-1629","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:18:05Z","timestamp":1706573885000},"page":"559-571","source":"Crossref","is-referenced-by-count":12,"title":["Exertional Stress-induced Pathogenic Luminal Content Translocation\n                    \u2013 Friend or Foe?"],"prefix":"10.1055","volume":"45","author":[{"given":"Kayla","family":"Henningsen","sequence":"additional","affiliation":[{"name":"Nutrition Dietetics & Food, Monash University Faculty of\n                    Medicine Nursing and Health Sciences, Notting Hill, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Martinez","sequence":"additional","affiliation":[{"name":"Nutrition Dietetics & Food, Monash University Faculty of\n                    Medicine Nursing and Health Sciences, Notting Hill, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo J. S.","family":"Costa","sequence":"additional","affiliation":[{"name":"Nutrition Dietetics & Food, Monash University Faculty of\n                    Medicine Nursing and Health Sciences, Notting Hill, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/a-1096-0980","article-title":"Defining off-road running: A position statement from the Ultra Sports Science\n                    Foundation","volume":"41","author":"V Scheer","year":"2020","journal-title":"Int J Sports Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s40279-021-01561-3","article-title":"Potential long-term health problems associated with ultra-endurance running: A\n                    narrative review","volume":"52","author":"V Scheer","year":"2022","journal-title":"Sports 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