{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:00:48Z","timestamp":1791820848444,"version":"4.3.4"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"General Program of the National Natural Science Foundation of China","award":["82173175"],"award-info":[{"award-number":["82173175"]}]},{"name":"General Program of the National Natural Science Foundation of China","award":["82001320"],"award-info":[{"award-number":["82001320"]}]},{"name":"Knowledge Innovation Program of the Chinese Academy of Sciences","award":["JH2022007"],"award-info":[{"award-number":["JH2022007"]}]},{"name":"Clinical Research Incubation Project, West China Hospital, Sichuan University","award":["2020HXFH036"],"award-info":[{"award-number":["2020HXFH036"]}]},{"name":"Key R&D projects in Sichuan province","award":["2022YFS0319"],"award-info":[{"award-number":["2022YFS0319"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003There is still no consensus on whether primary pontine hemorrhage (PPH) should be managed conservatively or treated promptly via surgical evacuation of the hematoma. The purpose of this study was to assess the therapeutic effect of robotic frameless stereotactic aspiration with thrombolysis in the treatment of PPH.<\/jats:p><jats:p>\n          Methods\u2003A total of 39 patients with PPH treated between January 2012 and November 2016 were included in the study. Sixteen patients underwent frameless stereotactic surgical treatment (ST group) and 23 patients underwent conservative treatment (CT group). Clinical and radiologic parameters were assessed, and the patient outcomes were analyzed over a 6-month follow-up period.<\/jats:p><jats:p>\n          Results\u2003Surgical treatment did not result in any intracranial infections, or complications. Baseline characteristics did not significantly differ between the two groups. At discharge, the average Glasgow Coma Scale (GCS) score and the overall Glasgow Outcome Scale (GOS) score were significantly higher in the ST group compared to the CT group (p\u2009&lt;\u20090.05). The mortality rate (GOS score 1) was significantly lower in the ST group (18.75%, 3\/16) than in the CT group (52.17%, 12\/23). For patients with hematoma volumes of 5 to 10\u2009mL or GCS scores of 6 to 8, following treatment, the ST group exhibited markedly higher GOS scores in comparison to the CT group.<\/jats:p><jats:p>\n          Conclusion\u2003Our study suggests that robotic frameless stereotactic aspiration with thrombolysis is a safe and efficient method for the treatment of PPH. Patients with hematomas of 5 to 10\u2009mL or GCS scores of 6 to 8 could benefit from surgery.<\/jats:p>","DOI":"10.1055\/a-2235-5453","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T23:41:42Z","timestamp":1703720502000},"page":"111-119","source":"Crossref","is-referenced-by-count":7,"title":["Robotic Frameless Stereotactic Aspiration with Thrombolysis for Primary Pontine Hemorrhage: A Therapeutic Evaluation of a Retrospective Cohort Study"],"prefix":"10.1055","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7822-116X","authenticated-orcid":false,"given":"Chongxi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"He","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China."},{"name":"The affiliated Bayi Brain Hospital, The 7th Medical Center, PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-8186","authenticated-orcid":false,"given":"Jianguo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1474-4422(09)70340-0","article-title":"Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis","volume":"9","author":"C J van Asch","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e787","DOI":"10.1016\/j.wneu.2019.04.258","article-title":"Safety and efficacy of minimally invasive stereotactic aspiration with multicatheter insertion compared with conventional craniotomy for large spontaneous intracerebral hemorrhage (\u226550\u2009mL)","volume":"128","author":"C H Kim","year":"2019","journal-title":"World Neurosurg"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.clineuro.2005.02.007","article-title":"Clinical and neuroradiological predictors of mortality in patients with primary pontine hemorrhage","volume":"108","author":"K Balci","year":"2005","journal-title":"Clin Neurol Neurosurg"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1468-1331.2012.03724.x","article-title":"The prediction of 30-day mortality in patients with primary pontine hemorrhage: a scoring system comparison","volume":"19","author":"K B Huang","year":"2012","journal-title":"Eur J Neurol"},{"issue":"9890","key":"ref5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(13)60986-1","article-title":"Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial","volume":"382","author":"A D Mendelow","year":"2013","journal-title":"Lancet"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.3171\/foc.2003.15.4.0","article-title":"Spontaneous intracerebral hemorrhage: a review","volume":"15","author":"M E Fewel","year":"2003","journal-title":"Neurosurg Focus"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1042-3680(18)30572-2","article-title":"Primary pontine hemorrhagic events. 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