{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:19:04Z","timestamp":1781734744832,"version":"3.54.5"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003We aimed to determine the incidence and risk factors for development of diabetes insipidus (DI) and syndrome of inappropriate antidiuretic hormone secretion (SIADH) after transsphenoidal hypophysectomy (TSH) for resection of a pituitary adenoma.<\/jats:p><jats:p>\n          Methods\u2003This was a retrospective study of 403 adult patients undergoing TSH for pituitary adenoma. Clinical variables, tumor characteristics, and operative factors were collected. Incidences of DI and SIADH were determined, including timing in the perioperative period. Independent predictors of developing DI and SIADH were identified using multivariable logistic regression.<\/jats:p><jats:p>\n          Results\u2003Following TSH, 21.3% of patients developed DI at a mean 2.6 days and 7.4% developed SIADH at a mean 4.7 days. DI was negatively associated with older age (odds ratio [OR]\u2009=\u20090.98, 95% confidence interval [CI]: 0.96\u20130.99, p\u2009=\u20090.029). DI was positively associated with female sex (OR\u2009=\u20092.26, 95% CI: 1.24\u20134.11, p\u2009=\u20090.008), increase in anteroposterior tumor size (OR\u2009=\u20091.54, 95% CI: 1.11\u20132.13, p\u2009=\u20090.010), intraoperative cerebrospinal fluid (CSF) leak (OR\u2009=\u20092.29, 95% CI: 1.25\u20134.19, p\u2009=\u20090.008), and every 100\u2009mL of estimated blood loss (EBL) (OR\u2009=\u20091.18, 95% CI: 1.01\u20131.39, p\u2009=\u20090.046). Development of SIADH was positively associated with intraoperative CSF leak (OR\u2009=\u20093.56, 95% CI: 1.24\u201310.21, p\u2009=\u20090.018) on multivariate analysis.<\/jats:p><jats:p>\n          Conclusion\u2003DI and SIADH occur in the minority of patients undergoing TSH, but vigilance for their development must be maintained for days after the surgery. Development of DI after TSH is multifactorial, having possible patient-specific risk factors and risk related to the complexity of surgical dissection, reflected by tumor size, intraoperative CSF leak, and EBL. Development of SIADH could be associated with intraoperative CSF leak occurrence.<\/jats:p>","DOI":"10.1055\/a-2235-7419","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T23:41:12Z","timestamp":1703720472000},"page":"039-045","source":"Crossref","is-referenced-by-count":2,"title":["Risk Factors for Development of Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone Secretion after Transsphenoidal Resection of Pituitary Adenoma"],"prefix":"10.1055","volume":"86","author":[{"given":"Gabrielle","family":"Petito","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhant H.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adithya","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geet","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjit","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Jana","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Forbes","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Zuccarello","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto O.","family":"Andaluz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-2325","authenticated-orcid":false,"given":"Ahmad R.","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1055\/s-0037-1604363","article-title":"Diabetes insipidus following endoscopic transsphenoidal surgery for pituitary adenoma","volume":"79","author":"A M Ajlan","year":"2018","journal-title":"J Neurol Surg B Skull 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