{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:13:56Z","timestamp":1783098836051,"version":"3.54.6"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Neurogenic pulmonary edema (NPE) following subarachnoid hemorrhage (SAH) is still one of the most catastrophic complications with high morbidity and mortality rates. Systemic sympathetic hyperactivity has been considered in the pathogenesis, but it has not been clarified. In this study, we investigate the relationship between the degeneration of the T3 dorsal root ganglion (DRG) and the development of NPE following spinal SAH.<\/jats:p><jats:p>\n          Methods\u2003The study was conducted on 23 rabbits. Five rabbits were used as the control group, 5 as the sham group (n\u2009=\u20095), and 13 as the study group. The correlation between the degenerated neuronal densities of the T3 nerve axons and neurons in the DRG and NPE scores was analyzed statistically.<\/jats:p><jats:p>\n          Results\u2003A correlation between the neuronal degeneration of the T3 nerve, its DRG, and high NPE scores was found in the study group and the sham group. Massive NPE was detected in the study group along with neural degeneration of T3 axons and ganglia.<\/jats:p><jats:p>\n          Conclusion\u2003The present study indicates that NPE and pulmonary artery vasospasm can be prevented by reducing T3 DRG degeneration.<\/jats:p>","DOI":"10.1055\/a-2235-8556","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T23:52:16Z","timestamp":1703807536000},"page":"265-271","source":"Crossref","is-referenced-by-count":3,"title":["Interaction between Neurogenic Pulmonary Edema and Thoracic 3 DRG Degeneration Following Spinal Subarachnoid Hemorrhage: First Experimental Study"],"prefix":"10.1055","volume":"86","author":[{"given":"Deniz","family":"Sirinoglu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ok Meydani Education and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buse","family":"Sarigul","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tuzla Government Hospital, Tuzla Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8189-2877","authenticated-orcid":false,"given":"Ayhan","family":"Kanat","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Recep Tayyip Erdogan University, Medical Faculty, Rize, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Dumlu","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ataturk University Medical Faculty, Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Demirtas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ataturk University Medical Faculty, Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1055\/s-0040-1720982","article-title":"Health economic aspects of aneurysmal subarachnoid hemorrhage: factors determining first year in-hospital treatment expenses","volume":"82","author":"S Ridwan","year":"2021","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"issue":"04","key":"ref2","first-page":"559","article-title":"The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study","volume":"21","author":"A M Musluman","year":"2011","journal-title":"Turk Neurosurg"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.emc.2017.07.001","article-title":"Subarachnoid hemorrhage: updates in diagnosis and management","volume":"35","author":"B Long","year":"2017","journal-title":"Emerg Med Clin North Am"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.wneu.2017.10.016","article-title":"The extracranial consequences of subarachnoid hemorrhage","volume":"109","author":"A Hall","year":"2018","journal-title":"World Neurosurg"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1055\/s-0039-3400952","article-title":"Microsurgical treatment of 86 anterior choroidal artery aneurysms: analysis of factors influencing the prognosis","volume":"81","author":"C Lu","year":"2020","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.14423\/SMJ.0000000000001457","article-title":"Pathophysiology and management of neurogenic pulmonary edema in patients with acute severe brain injury","volume":"115","author":"M A Maslonka","year":"2022","journal-title":"South Med J"},{"issue":"03","key":"ref7","first-page":"434","article-title":"Spinal subarachnoid hemorrhage induced intractable miotic pupil. A reminder of ciliospinal sympathetic center ischemia based miosis: an experimental study","volume":"29","author":"M D Aydin","year":"2019","journal-title":"Turk Neurosurg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e895","DOI":"10.1016\/j.wneu.2019.03.007","article-title":"Brachial artery vasospasm caused by cervical dorsal root ganglion degeneration after subarachnoid hemorrhage: an experimental study","volume":"126","author":"S Kayac\u0131","year":"2019","journal-title":"World Neurosurg"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"e201900303","DOI":"10.1590\/s0102-865020190030000003","article-title":"New determinants for casual peripheral mechanism of neurogenic lung edema in subarachnoid hemorrhage due to ischemic degeneration of vagal nerve, kidney and lung circuitry. Experimental study1","volume":"34","author":"C Soyalp","year":"2019","journal-title":"Acta Cir Bras"},{"issue":"04","key":"ref10","first-page":"477","article-title":"The effect of choroidal artery vasospasm on choroid plexus injury in subarachnoid hemorrhage: experimental study","volume":"21","author":"A Yilmaz","year":"2011","journal-title":"Turk Neurosurg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e861","DOI":"10.1016\/j.wneu.2022.05.063","article-title":"Protective felix culpa effect of superior sympathetic cervical ganglion degenerations on prevention of basilar artery spasm after subarachnoid hemorrhage: a preliminary experimental study","volume":"164","author":"B Sahin","year":"2022","journal-title":"World Neurosurg"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/1793-5482.145572","article-title":"First report of important causal relationship between the Adamkiewicz artery vasospasm and dorsal root ganglion cell degeneration in spinal subarachnoid hemorrhage: an experimental study using a rabbit model","volume":"12","author":"O N Turkmenoglu","year":"2017","journal-title":"Asian J Neurosurg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jns.2013.10.047","article-title":"Important casual association of carotid body and glossopharyngeal nerve and lung following experimental subarachnoid hemorrhage in rabbits. First report","volume":"336","author":"C Yolas","year":"2014","journal-title":"J Neurol Sci"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3724\/SP.J.1263.2011.00044","article-title":"Acute lung injury and acute respiratory distress syndrome: experimental and clinical investigations","volume":"8","author":"H I Chen","year":"2011","journal-title":"J Geriatr Cardiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.wneu.2016.04.067","article-title":"Rational roots of sympathetic overactivity by neurogenic pulmonary edema modeling arising from sympathyco-vagal imbalance in subarachnoid hemorrhage: an experimental study","volume":"92","author":"M R Onen","year":"2016","journal-title":"World Neurosurg"},{"issue":"S 06","key":"ref17","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S0304-3959(99)00135-9","article-title":"Unexplained peculiarities of the dorsal root ganglion","author":"M Devor","year":"1999","journal-title":"Pain"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00441-023-03770-w","article-title":"Ultrastructure of dorsal root ganglia","volume":"393","author":"R V Haberberger","year":"2023","journal-title":"Cell Tissue Res"},{"issue":"06","key":"ref19","first-page":"874","article-title":"Predictive role of external carotid artery vasospasm on cerebral ischemia after subarachnoid hemorrhage: experimental study","volume":"27","author":"N G Ozdemir","year":"2017","journal-title":"Turk Neurosurg"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1007\/s00701-010-0793-4","article-title":"Role of degenerated neuron density of dorsal root ganglion on anterior spinal artery vasospasm in subarachnoid hemorrhage: experimental study","volume":"152","author":"A Kanat","year":"2010","journal-title":"Acta Neurochir (Wien)"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"486","DOI":"10.17085\/apm.20052","article-title":"Incidence of inadvertent intercostal or epidural spread during thoracic sympathetic ganglion block","volume":"15","author":"J H Hong","year":"2020","journal-title":"Anesth Pain Med"},{"issue":"04","key":"ref22","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/jnr.23332","article-title":"Characterization of thoracic motor and sensory neurons and spinal nerve roots in canine degenerative myelopathy, a potential disease model of amyotrophic lateral sclerosis","volume":"92","author":"B R Morgan","year":"2014","journal-title":"J Neurosci Res"},{"key":"ref23","first-page":"1","article-title":"New experimental finding of dangerous autonomic ganglia changes in cardiac injury following subarachnoid hemorrhage; a reciprocal culprit-victim relationship between the brain and heart","author":"M D Aydin","year":"2022","journal-title":"Int J Neurosci"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/s-0040-1721682","article-title":"A brief review of brain's blood flow-metabolism coupling and pressure autoregulation","volume":"82","author":"T Papasilekas","year":"2021","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"issue":"06","key":"ref25","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1227\/01.NEU.0000068349.22859.C6","article-title":"Brain oxygenation and energy metabolism: part 1\u2014biological function and pathophysiology","volume":"52","author":"A Kanat","year":"2003","journal-title":"Neurosurgery"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1055\/s-0041-1735860","article-title":"Clinical outcome in cerebral vasospasm patients treated with and without intra-arterial nimodipine infusion","volume":"83","author":"V Yindeedej","year":"2022","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"issue":"03","key":"ref27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0034-5687(92)90087-D","article-title":"Inspiratory muscle activity during pulmonary edema in anesthetized dogs","volume":"89","author":"A Oliven","year":"1992","journal-title":"Respir Physiol"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1055\/s-0040-1721017","article-title":"The influence of music on neurosurgical cases: a neglected knowledge","volume":"82","author":"E R Gasenzer","year":"2021","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"issue":"07","key":"ref29","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1097\/SCS.0000000000005763","article-title":"The effect of neuroscientists on the studies of autonomic nervous system dysfunction following experimental subarachnoid hemorrhage","volume":"30","author":"B Ozdemir","year":"2019","journal-title":"J Craniofac Surg"},{"issue":"03","key":"ref30","first-page":"176","article-title":"Sciatic nerve injury following analgesic drug injection in rats: A histopathological examination","volume":"5","author":"H Bostan","year":"2018","journal-title":"North Clin Istanb"},{"issue":"04","key":"ref31","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1055\/s-0037-1608841","article-title":"How reliable is pupillary evaluation following subarachnoid hemorrhage? Effect of oculomotor nerve degeneration secondary to posterior communicating artery vasospasm: first experimental study","volume":"79","author":"C Ozturk","year":"2018","journal-title":"J Neurol Surg A Cent Eur Neurosurg"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2235-8556.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:26:01Z","timestamp":1744154761000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2235-8556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,28]]},"references-count":30,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,4,8]]},"published-print":{"date-parts":[[2025,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2235-8556","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12,28]]},"published":{"date-parts":[[2023,12,28]]}}}