{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T06:10:20Z","timestamp":1738131020990,"version":"3.33.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Many patients with neurofibromatosis type 2 (NF2) suffer from sensorineural hearing loss, and associated cochlear nerve compromise in NF2 patients makes auditory brainstem implant (ABI) an attractive treatment option. The long-term outcomes and benefits of the device are still being explored.<\/jats:p><jats:p>\n          Methods\u2003A retrospective review was conducted for 11 ABI recipients at a single-institution tertiary center between November 2017 and August 2022. Patients diagnosed with NF2 undergoing resection for concurrent vestibular schwannoma (VS) were included. Pre- and postaudiometric assessments were reviewed. Evaluation included pure-tone audiometry and speech testing.<\/jats:p><jats:p>\n          Results\u2003Our cohort included 11 patients with a median age of 34 years. All patients underwent a translabyrinthine approach for implant placement with concurrent VS resection. Average tumor size of VS was 2.87\u2009cm. Preoperatively, 8 patients had pure-tone averages with no response at 110\u2009dB, 2 were within mild\u2013moderate hearing loss (25\u201345\u2009dB), and one patient had a PTA of profound loss (92\u2009dB). Postoperatively, 9 (81%) patients had improvement in PTA. In total, seven patients reported mild side effects upon ABI activation which included dizziness (n\u2009=\u20092), tinnitus (n\u2009=\u20091), and abdominal and lower extremity tingling sensation (n\u2009=\u20093). Of the seven patients with early speech perception (ESP) scores, five had a score &gt;75%, indicating the auditory ability to detect pattern perception upon auditory stimulation through the ABI alone.<\/jats:p><jats:p>\n          Conclusion\u2003Nine of 11 patients derived benefits from ABI placement. These findings demonstrate that ABI placement during concurrent VS resection can provide a significant hearing benefit for NF2 patients.<\/jats:p>","DOI":"10.1055\/a-2236-0113","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T23:51:46Z","timestamp":1703807506000},"page":"006-012","source":"Crossref","is-referenced-by-count":0,"title":["Audiometric Outcomes of Auditory Brainstem Implantation during Vestibular Schwannoma Resection in NF2 Patients"],"prefix":"10.1055","volume":"86","author":[{"given":"V\u00edctor","family":"de Cos","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine, La Jolla, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Gibson","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine, La Jolla, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivienne","family":"Li","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine, La Jolla, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"La Monte","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine, La Jolla, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omid","family":"Moshtaghi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, UC San Diego Medical Center, San Diego, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, UC San Diego Medical Center, San Diego, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usman","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, UC San Diego Medical Center, San Diego, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, UC San Diego Medical Center, San Diego, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc S.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, UC San Diego Medical Center, San Diego, California, United 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Arriaga","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1097\/MAO.0000000000000584","article-title":"New outcomes with auditory brainstem implants in NF2 patients","volume":"35","author":"R Behr","year":"2014","journal-title":"Otol Neurotol"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.wjorl.2021.02.002","article-title":"Clinical and scientific innovations in auditory brainstem implants","volume":"7","author":"K R Shetty","year":"2021","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3171\/jns.2002.96.6.1063","article-title":"Multichannel auditory brainstem implant: update on performance in 61 patients","volume":"96","author":"S R Otto","year":"2002","journal-title":"J 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