{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:16:51Z","timestamp":1791595011161,"version":"4.3.4"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Reconstr Microsurg"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Salivary fistula formation is a common and serious complication following head and neck reconstruction. Because it can cause delayed wound healing and infection and carotid artery rupture in severe cases, hence, early detection and treatment are crucial. This study was designed to identify early predictors of postoperative fistula formation.<\/jats:p><jats:p>\n          Methods\u2003We conducted a retrospective analysis of patients who underwent head and neck reconstruction between 2015 and 2022. Body temperature, serum white blood cell (WBC) count, and serum C-reactive protein (CRP) levels were assessed until postoperative day (POD) 14 and compared between patients with and without fistula.<\/jats:p><jats:p>\n          Results\u2003In this study, 200 patients were included. No significant differences in body temperature and WBC count were observed between the two groups during the entire study period. CRP levels after POD2 were higher in the fistula group than in the without fistula group. From the receiver operating characteristic curves comparing the two groups, the best cutoff level for CRP was 6.27\u2009mg\/dL from POD7 to POD8, with 77.1% sensitivity, 69.8% specificity, and 90.1% negative predictive value.<\/jats:p><jats:p>\n          Conclusion\u2003CRP is a valuable predictor of fistula formation following head and neck reconstruction. The course of CRP levels in patients with fistulas remains consistently elevated compared to patients without fistulas, and it is particularly useful for the exclusion diagnosis of fistula.<\/jats:p>","DOI":"10.1055\/a-2238-7591","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T23:54:44Z","timestamp":1704412484000},"page":"466-472","source":"Crossref","is-referenced-by-count":3,"title":["Early Predictors of Fistula Formation Following Head and Neck Reconstruction"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-9998","authenticated-orcid":false,"given":"Daisuke","family":"Atomura","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Kobe University Hospital International Clinical Cancer Research Center, Kobe, Japan"},{"name":"Department of Plastic Surgery, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Osaki","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hyogo Cancer Center, Akashi, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemichi","family":"Iwae","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Hyogo Cancer Center, Akashi, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/01.mlg.0000157827.92884.c5","article-title":"Effect of salivary fistulas on free flap failure: a 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