{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:36:47Z","timestamp":1782470207747,"version":"3.54.5"},"reference-count":94,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aging is a major risk factor for retinal neurodegenerative diseases. Aged mammalian\n          retinal ganglion cells (RGCs) lack the ability to regenerate axons after injury. Rodent\n          models suggest that older age increases the vulnerability of RGCs to injury and impairs\n          RGC function as well as their functional recovery. Molecular changes \u2013 including decreased\n          circulating levels of brain-derived neurotrophic factor (BDNF) \u2013 might contribute to\n          impaired RGC dendritic extension during aging. Moreover, age-related mitochondrial\n          dysfunction plays a major role in aging processes, as it leads to reduced adenosine\n          triphosphate and increased generation of reactive oxygen species. Autophagy activity is\n          necessary for the maintenance of cellular homeostasis and decreases with aging in the\n          central nervous system. During aging, vascular insufficiency may lead to impaired oxygen\n          and nutrient supply to RGCs. Microglial cells undergo morphological changes and functional\n          impairment with aging, which might compromise retinal homeostasis and promote an\n          inflammatory environment. Addressing these age-related changes by means of a low-energy\n          diet, exercise, and neurotrophic factors might prevent age-related functional impairment\n          of RGCs. This review focuses on the current understanding of aging RGCs and key players\n          modulating those underlying mechanisms.<\/jats:p>","DOI":"10.1055\/a-2239-0290","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:13:26Z","timestamp":1709079206000},"page":"162-169","source":"Crossref","is-referenced-by-count":18,"title":["The Impact of Aging on the Function of Retinal Ganglion Cells"],"prefix":"10.1055","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3473-7997","authenticated-orcid":false,"given":"Julia","family":"Prinz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, RWTH Aachen University, Aachen,\n          Germany"},{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital of\n          Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, RWTH Aachen University, Aachen,\n          Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital of\n          Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Prokosch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital of\n          Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","article-title":"Reprogramming to recover youthful epigenetic information and restore vision","volume":"588","author":"Y 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