{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:59:06Z","timestamp":1790855946130,"version":"4.1.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>E-Zigaretten werden in klinischen Studien zur Tabakentw\u00f6hnung eingesetzt. Aufgrund der Gesundheitsrisiken, die mit dem Gebrauch von E-Zigaretten verbunden sind, sollten die Ergebnisse klinischer Studien vollst\u00e4ndig berichtet werden, einschlie\u00dflich des fortgesetzten ausschlie\u00dflichen Gebrauchs und des gemeinsamen Gebrauchs von Tabak und E-Zigaretten. Die Ergebnisse zur Nikotinentw\u00f6hnung sollten als prim\u00e4rer Endpunkt ebenso wie die Analyse der blo\u00dfen Beendigung des Tabakkonsums berichtet werden. Da es derzeit keine stichhaltigen Belege daf\u00fcr gibt, dass die Reduzierung des Zigarettenkonsums wesentliche gesundheitliche Vorteile mit sich bringt, sollte die Reduzierung des Zigarettenkonsums nicht als Gesundheitsendpunkt in klinischen Studien verwendet werden. Die fortbestehende Nikotinabh\u00e4ngigkeit sollte als \u201eunerw\u00fcnschtes Ereignis\u201c in die Berichterstattung \u00fcber die Studienergebnisse aufgenommen werden.\n    <\/jats:p>","DOI":"10.1055\/a-2243-9399","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:10:26Z","timestamp":1706141426000},"page":"561-565","source":"Crossref","is-referenced-by-count":3,"title":["Beabsichtigte und unbeabsichtigte Wirkungen von E-Zigaretten in klinischen Studien \u2013 ein Pl\u00e4doyer f\u00fcr (mehr) Transparenz"],"prefix":"10.1055","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7163-5738","authenticated-orcid":false,"given":"Reiner","family":"Hanewinkel","sequence":"additional","affiliation":[{"name":"IFT-Nord gGmbH, Institut f\u00fcr Therapie- und Gesundheitsforschung, Kiel, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7617-0266","authenticated-orcid":false,"given":"Sabina","family":"Ulbricht","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Community Medcine, Abteilung Pr\u00e4ventionsforschung und Sozialmedizin, Universit\u00e4tsmedizin Greifswald, Greifswald, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1055\/a-2034-6214","article-title":"Elektronische Zigaretten \u2013 Schadensminimierung oder Schadensverl\u00e4ngerung?","volume":"77","author":"R Hanewinkel","year":"2023","journal-title":"Pneumologie"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1159\/000360220","article-title":"Estimating the harms of nicotine-containing products using the MCDA approach","volume":"20","author":"DJ Nutt","year":"2014","journal-title":"Eur Addict Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2105\/ajph.2019.305424","article-title":"Invalidity of an Oft-Cited Estimate of the Relative Harms of Electronic Cigarettes","volume":"110","author":"T Eissenberg","year":"2020","journal-title":"Am J Public Health"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1161\/circulationaha.121.056777","article-title":"E-Cigarettes and Cardiopulmonary Health: Review for Clinicians","volume":"145","author":"EW Neczypor","year":"2022","journal-title":"Circulation"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1161\/circresaha.123.321565","article-title":"Electronic Nicotine Delivery Systems and Cardiovascular\/Cardiometabolic Health","volume":"132","author":"MJ Mears","year":"2023","journal-title":"Circ Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"101748","DOI":"10.1016\/j.cpcardiol.2023.101748","article-title":"Association of Electronic Cigarette Exposure on Cardiovascular Health: A Systematic Review and Meta-Analysis","volume":"48","author":"TJ Siddiqi","year":"2023","journal-title":"Curr Probl Cardiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3390\/arm91060038","article-title":"E-Cigarettes and Associated Health Risks: An Update on Cancer Potential","volume":"91","author":"R Sahu","year":"2023","journal-title":"Adv Respir Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"20967","DOI":"10.1038\/s41598-022-25594-4","article-title":"Electronic cigarettes use and 'dual use' among the youth in 75 countries: estimates from Global Youth Tobacco Surveys (2014\u20132019)","volume":"12","author":"CT Sreeramareddy","year":"2022","journal-title":"Sci Rep"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntad12410.1093\/ntr\/ntad124","article-title":"Changes in e-cigarette use, cigarette smoking, and dual use among the youth (13\u201315 years) in 10 countries (2013\u20132019) \u2013 analyses of Global Youth Tobacco Surveys (GYTS)","author":"CT Sreeramareddy","year":"2023","journal-title":"Nicotine Tob Res"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1093771","DOI":"10.3389\/fpubh.2023.1093771","article-title":"Dual and poly-use of novel and conventional nicotine and tobacco product use in Europe: Challenges for population health, regulatory policies, and the ways ahead","volume":"11","author":"DT Chen","year":"2023","journal-title":"Front Public Health"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s40429-022-00448-1","article-title":"Dual Use of Combustible Cigarettes and E-cigarettes: a Narrative Review of Current Evidence","volume":"9","author":"SRM Coleman","year":"2022","journal-title":"Curr Addict Rep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1055\/a-2146-7087","article-title":"Konsum von Tabakzigaretten, E-Zigaretten und Wasserpfeifen bei Kindern und Jugendlichen. 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