{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T05:26:23Z","timestamp":1741325183701,"version":"3.38.0"},"reference-count":54,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Orthop Unfall"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Eine schmerzhafte Reduktion der Beweglichkeit der Schulter, die als \u201eSchultersteife\u201c bekannt ist, kann sowohl prim\u00e4r idiopathisch auftreten als auch sekund\u00e4r, bspw. als Folge chirurgischer Eingriffe. Es existieren verschiedene Faktoren, die zur Entstehung der prim\u00e4ren Schultersteife beitragen k\u00f6nnen. Daher fasst diese \u00dcbersichtsarbeit pathophysiologische Mechanismen, genetische Einfl\u00fcsse, endokrinologische St\u00f6rungen, metabolische Krankheitsbilder sowie andere Erkrankungen und medizinisch-therapeutische Ans\u00e4tze zusammen, die m\u00f6glicherweise einen Einfluss auf die Entwicklung der prim\u00e4ren Schultersteife haben k\u00f6nnten.<\/jats:p>","DOI":"10.1055\/a-2245-4896","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T23:47:05Z","timestamp":1709941625000},"page":"578-583","source":"Crossref","is-referenced-by-count":0,"title":["Risikofaktoren f\u00fcr die Entstehung der prim\u00e4ren Schultersteife: ein aktueller \u00dcberblick"],"prefix":"10.1055","volume":"162","author":[{"given":"Suncana","family":"van Hattem","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Universit\u00e4tsklinikum Bonn, Bonn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva-Maria","family":"Regener","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Universit\u00e4tsklinikum Bonn, Bonn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Prangenberg","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Universit\u00e4tsklinikum Bonn, Bonn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas Christian","family":"Strauss","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Universit\u00e4tsklinikum Bonn, Bonn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"de Girolamo","sequence":"additional","affiliation":[{"name":"Orthopaedics Biotechnology Laboratory, IRCCS Istituto Ortopedico Galeazzi, Mailand, Italien"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"Burger","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Universit\u00e4tsklinikum Bonn, Bonn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter Christian","family":"Wirtz","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Universit\u00e4tsklinikum Bonn, Bonn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Cucchi","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Universit\u00e4tsklinikum Bonn, Bonn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.arthro.2016.03.024","article-title":"Shoulder Stiffness: Current Concepts and Concerns","volume":"32","author":"E Itoi","year":"2016","journal-title":"Arthrosc J Arthrosc Relat Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.1007\/s00402-021-04285-1","article-title":"Treatment of partial rotator cuff lesions is associated with a higher frequency of post-operative shoulder stiffness. A prospective investigation on the role of surgery-related risk factors for this complication","volume":"142","author":"D Cucchi","year":"2021","journal-title":"Arch Orthop Trauma Surg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1302\/0301-620X.87BSUPP_II.0870161c","article-title":"Natural history and genetics of frozen shoulder a 1\u201320 year follow up of 273 patients","volume":"87-B(Supp. II)","author":"G Hand","year":"2005","journal-title":"Orthop Procs"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1177\/1758573216676786","article-title":"Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments","volume":"9","author":"HV Le","year":"2017","journal-title":"Shoulder Elbow"},{"key":"ref5","first-page":"5709","article-title":"Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after rotator cuff repair","volume":"8","author":"Y Ling","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1684\/ecn.2016.0382","article-title":"TGF-\u03b21 functional polymorphisms: a review","volume":"27","author":"GC Martelossi Cebinelli","year":"2016","journal-title":"Eur Cytokine Netw"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1002\/jor.24228","article-title":"Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: A case-control study","volume":"37","author":"C Cohen","year":"2019","journal-title":"J Orthop Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1002\/jor.22676","article-title":"A myofibroblast-mast cell-neuropeptide axis of fibrosis in post-traumatic joint contractures: an in vitro analysis of mechanistic components","volume":"32","author":"KA Hildebrand","year":"2014","journal-title":"J Orthop Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1093\/rheumatology\/keg159","article-title":"Genetic associations between frozen shoulder and tennis elbow: a female twin study","volume":"42","author":"AJ Hakim","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1016\/j.jse.2012.10.049","article-title":"Risk factors in idiopathic adhesive capsulitis: a case control study","volume":"22","author":"K Wang","year":"2013","journal-title":"J Shoulder Elbow Surg"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/S1297-319X(03)00128-3","article-title":"Idiopathic hypoparathyroidism and adhesive capsulitis of the shoulder in two first-degree relatives","volume":"71","author":"T Harzy","year":"2004","journal-title":"Joint Bone Spine"},{"key":"ref12","first-page":"33","article-title":"Histocompatibility type and racial incidence in frozen shoulder","volume":"65","author":"TE Rizk","year":"1984","journal-title":"Arch Phys Med Rehabil"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.2106\/JBJS.RVW.O.00007","article-title":"Is There a Genetic Predisposition to Frozen Shoulder?: A Systematic Review and Meta-Analysis","volume":"4","author":"AD Prodromidis","year":"2016","journal-title":"JBJS Rev"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.2106\/JBJS.21.01407","article-title":"Genome-Wide Association Study of Adhesive Capsulitis Suggests Significant Genetic Risk Factors","volume":"104","author":"S Kulm","year":"2022","journal-title":"J Bone Jt Surg"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e1009577","DOI":"10.1371\/journal.pgen.1009577","article-title":"A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor","volume":"17","author":"HD Green","year":"2021","journal-title":"PLOS Genet"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.jse.2022.07.005","article-title":"A shared genetic architecture between adhesive capsulitis and Dupuytren disease","volume":"32","author":"SK Kim","year":"2023","journal-title":"J Shoulder Elbow Surg"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"26","DOI":"10.11138\/mltj\/2016.6.1.026","article-title":"Adhesive capsulitis of the shoulder and diabetes: a meta-analysis of prevalence","volume":"6","author":"NH Zreik","year":"2016","journal-title":"Muscles Ligaments Tendons J"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1016\/j.jse.2023.01.033","article-title":"Association Between Adhesive Capsulitis and Thyroid Disease: A Meta-Analysis","volume":"32","author":"SH Chuang","year":"2023","journal-title":"J Shoulder Elbow Surg"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.mce.2011.11.019","article-title":"Testosterone inhibits transforming growth factor-\u03b2 signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action","volume":"350","author":"M Braga","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1007\/s00167-007-0291-2","article-title":"Idiopathic adhesive capsulitis of the shoulder: a review","volume":"15:","author":"S Brue","year":"2007","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1136\/bmj.331.7530.1453","article-title":"Frozen shoulder","volume":"331","author":"R Dias","year":"2005","journal-title":"BMJ"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.1038\/srep04183","article-title":"Hyperthyroidism is a Risk Factor for Developing Adhesive Capsulitis of the Shoulder: A Nationwide Longitudinal Population-Based Study","volume":"4","author":"SW Huang","year":"2014","journal-title":"Sci Rep"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.mporth.2011.01.007","article-title":"(ii) Frozen shoulder","volume":"25","author":"T Bunker","year":"2011","journal-title":"Orthop Trauma"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1016\/j.jse.2020.03.017","article-title":"Association between fasting glucose levels and adhesive capsulitis in a normoglycemic population: a case-control study","volume":"29","author":"HB Park","year":"2020","journal-title":"J Shoulder Elbow Surg"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.4103\/jfmpc.jfmpc_244_19","article-title":"Is it necessary to screen patient with adhesive capsulitis of shoulder for diabetes mellitus?","volume":"8","author":"S Rai","year":"2019","journal-title":"J Fam Med Prim Care"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/ksa.12017","article-title":"A high level of scientific evidence is available to guide treatment of primary shoulder stiffness: The SIAGASCOT consensus","volume":"32","author":"D Cucchi","year":"2024","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3261","DOI":"10.1177\/03635465231189797","article-title":"Increased Expression of Adipokines in Patients With Frozen Shoulder","volume":"51","author":"Y Qiao","year":"2023","journal-title":"Am J Sports Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.mehy.2016.01.002","article-title":"Adhesive capsulitis: An age related symptom of metabolic syndrome and chronic low-grade inflammation?","volume":"88","author":"M Pietrzak","year":"2016","journal-title":"Med Hypotheses"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/jdi.12491","article-title":"Diabetes and shoulder disorders","volume":"7","author":"C Hsu","year":"2016","journal-title":"J Diabetes Investig"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1007\/s00167-015-3906-z","article-title":"Subclinical hypothyroidism and diabetes as risk factors for postoperative stiff shoulder","volume":"25","author":"D Blonna","year":"2015","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e6583","DOI":"10.1097\/MD.0000000000006583","article-title":"Changes of transforming growth factor beta 1 in patients with type 2 diabetes and diabetic nephropathy: A PRISMA-compliant systematic review and meta-analysis","volume":"96","author":"YC Qiao","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.imlet.2017.04.003","article-title":"Serum TNF-\u03b1 concentrations in type 2 diabetes mellitus patients and diabetic nephropathy patients: A systematic review and meta-analysis","volume":"186","author":"YL Chen","year":"2017","journal-title":"Immunol Lett"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.arrct.2021.100141","article-title":"Diabetes as a Prognostic Factor in Frozen Shoulder: A Systematic Review","volume":"3","author":"BP Dyer","year":"2021","journal-title":"Arch Rehabil Res Clin Transl"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1051\/sicotj\/2022036","article-title":"Arthroscopic rotator interval release for frozen shoulder, comparative study between diabetic and non-diabetic patients","volume":"8","author":"W Tawfeek","year":"2022","journal-title":"SICOT J"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1302\/0301-620X.99B6.BJJ-2016-1133.R1","article-title":"Recurrence of frozen shoulder after manipulation under anaesthetic (MUA)","volume":"99-B","author":"DA Woods","year":"2017","journal-title":"Bone Joint J"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1016\/j.jse.2011.11.006","article-title":"The outcome of manipulation under general anesthesia for the management of frozen shoulder in patients with diabetes mellitus","volume":"21","author":"EF Jenkins","year":"2012","journal-title":"J Shoulder Elbow Surg"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1302\/0301-620X.77B5.7559689","article-title":"Frozen shoulder and lipids","volume":"77","author":"TD Bunker","year":"1995","journal-title":"J Bone Joint Surg Br"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"232596712098680","DOI":"10.1177\/2325967120986808","article-title":"Hyperlipidemia Is a Risk Factor of Adhesive Capsulitis: Real-World Evidence Using the Taiwanese National Health Insurance Research Database","volume":"9","author":"JY Wang","year":"2021","journal-title":"Orthop J Sport Med"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e35656","DOI":"10.1097\/MD.0000000000035656","article-title":"The causal relationship between ever smoked and frozen shoulder: A two-sample Mendelian randomization","volume":"102","author":"GH Deng","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"787","DOI":"10.3390\/jcm9030787","article-title":"Patients with Axial Spondylarthritis Are at Risk of Developing Adhesive Capsulitis: Real-World Evidence Database Study in Taiwan","volume":"9","author":"SW Huang","year":"2020","journal-title":"J Clin Med"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1055\/s-0037-1608951","article-title":"Risk Factors for Shoulder Stiffness: Current Concepts","volume":"5","author":"D Cucchi","year":"2017","journal-title":"Joints"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1136\/jnnp.52.1.63","article-title":"Frozen shoulder and other shoulder disturbances in Parkinson\u2019s disease","volume":"52","author":"D Riley","year":"1989","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref44","first-page":"191","article-title":"A prospective study of adhesive capsulitis of the shoulder (\u201cfrozen shoulder\u201d) in a high risk population","volume":"50","author":"FE Bruckner","year":"1981","journal-title":"Q J Med"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s13018-024-04600-7","article-title":"Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder","volume":"19","author":"W Lu","year":"2024","journal-title":"J Orthop Surg Res"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"352","DOI":"10.2174\/1874325001307010352","article-title":"The Frozen Shoulder: Myths and Realities","volume":"7","author":"MT Nagy","year":"2013","journal-title":"Open Orthop J"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"e2056","DOI":"10.1002\/pri.2056","article-title":"Does the psychological profile of a patient with frozen shoulder predict future outcome? A systematic review","volume":"29","author":"F Brindisino","year":"2024","journal-title":"Physiother Res Int"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1080\/13548506.2013.873814","article-title":"A report on the prevalence of depression and anxiety in patients with frozen shoulder and their relations to disease status","volume":"19","author":"H Ding","year":"2014","journal-title":"Psychol Health Med"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/bjc.2017.146","article-title":"Frozen shoulder and risk of cancer: a population-based cohort study","volume":"117","author":"AB Pedersen","year":"2017","journal-title":"Br J Cancer"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.3390\/ijerph17103592","article-title":"Risk of Herpes Zoster in Patients with Adhesive Capsulitis of the Shoulder","volume":"17","author":"CY Hsu","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1080\/00015458.2012.11680872","article-title":"Post-vaccination Frozen Shoulder Syndrome. Report of 3 Cases","volume":"112","author":"I Degreef","year":"2012","journal-title":"Acta Chir Belg"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"4964","DOI":"10.1016\/j.vaccine.2022.06.002","article-title":"Shoulder injury related to vaccine administration (SIRVA) after COVID-19 vaccination","volume":"40","author":"JR Bass","year":"2022","journal-title":"Vaccine"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.jseint.2022.02.013","article-title":"Frozen shoulder after COVID-19 vaccination","volume":"6","author":"D Sahu","year":"2022","journal-title":"JSES Int"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s40477-022-00739-3","article-title":"Adhesive capsulitis after COVID-19 vaccine injection: a peculiar case treated with combined bursa distention and glenohumeral capsular hydrodilatation","volume":"26","author":"A Biglia","year":"2023","journal-title":"J Ultrasound"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"911532","DOI":"10.3389\/fmed.2022.911532","article-title":"Risk Factors for the Onset of Frozen Shoulder in Middle-Aged and Elderly Subjects Within 1 Year of Discharge From a Hospitalization That Involved Intravenous Infusion: A Prospective Cohort Study","volume":"9","author":"W Cao","year":"2022","journal-title":"Front Med"}],"container-title":["Zeitschrift f\u00fcr Orthop\u00e4die und Unfallchirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2245-4896.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:43:38Z","timestamp":1741308218000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2245-4896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,8]]},"references-count":54,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2024,11,26]]},"published-print":{"date-parts":[[2024,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2245-4896","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1864-6697","1864-6743"],"issn-type":[{"type":"print","value":"1864-6697"},{"type":"electronic","value":"1864-6743"}],"subject":[],"published":{"date-parts":[[2024,3,8]]}}}