{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T02:42:24Z","timestamp":1751424144158,"version":"3.37.3"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n            Einleitung Mit einer Pr\u00e4valenz von 0,55\u20134% ist die chronische Rhinosinusitis mit nasalen Polypen (CRSwNP) ein relevanter Bestandteil der t\u00e4glichen Arbeit in deutschen HNO-Kliniken. Ziel der Fragebogen-basierten Datenerhebung war es, den aktuellen Behandlungsstand der CRSwNP in deutschen Krankenh\u00e4usern zu erfassen.<\/jats:p><jats:p>\n            Material und Methoden Hierzu erfolgte der Versand von 24 Fragen innerhalb eines anonymisierten Onlinefragenbogens an deutsche HNO-Kliniken.<\/jats:p><jats:p>\n            Ergebnisse Von 160 angeschriebenen HNO-Kliniken nahmen 50 an der Umfrage teil (31,3%). Davon f\u00fchrten 76% mehr als 100 Nasennebenh\u00f6hlenoperationen j\u00e4hrlich und 38% Biologikatherapien an bisher mehr als 50 Patienten durch. Mit 80% bzw. 60% stellten Kochsalzsp\u00fclungen und intranasale Glukokortikoide (GKS) die h\u00e4ufigsten konservativen Therapiema\u00dfnahmen dar. Systemische GKS-Gaben und nasale GKS-Sp\u00fclungen waren mit 52% und 20% weniger verbreitet. 80% der Kliniken nutzen Biologika in der Therapie der CRSwNP, wovon 70% Dupilumab bevorzugten. Zur Therapie bei Aspirin (ASS) -Intoleranz wurden in 52% Biologika einer Desaktivierung mit ASS (26%) vorgezogen. Vor Biologikagabe wurden in 90% der Nasal Polyp Score, in 84% der SNOT-22-Fragebogen, in 60\u201372% Surrogatmarker einer Typ-2-Inflammation und in 50% eine Computertomografie der Nasennebenh\u00f6hlen (CT NNH) bestimmt bzw. angefertigt. Der abschlie\u00dfende Therapieerfolg wurde in 50% nach 24 Wochen bewertet.<\/jats:p><jats:p>\n            Schlussfolgerung Zumeist folgten die antwortenden Kliniken den deutschen und europ\u00e4ischen Empfehlungen zur Diagnostik und Therapie der CRSwNP. Die Therapie mit Biologika ist mittlerweile weit verbreitet. Die h\u00e4ufige pr\u00e4operative Gabe systemischer GKS und Durchf\u00fchrung einer CT NNH vor Therapiestart mit einem Biologikum sind bei aktuell weiter Verbreitung diskutabel.<\/jats:p>","DOI":"10.1055\/a-2246-2793","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T23:40:56Z","timestamp":1712101256000},"page":"646-654","source":"Crossref","is-referenced-by-count":1,"title":["Ergebnisse einer Umfrage zur aktuellen Behandlung der chronischen Rhinosinusitis mit nasalen Polypen"],"prefix":"10.1055","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-0797","authenticated-orcid":false,"given":"Eric","family":"Deuss","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Essen, Essen, 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Eckrich","sequence":"additional","affiliation":[{"name":"Hals-, Nasen-, Ohrenklinik und Poliklinik, Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Lang","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludger","family":"Klimek","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Rhinologie und Allergologie Wiesbaden, Wiesbaden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Ernst","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsklinikum Frankfurt, Frankfurt, 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