{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:24:47Z","timestamp":1730870687120,"version":"3.28.0"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>\n            Objective Hemodynamically significant patent ductus arteriosus (hsPDA) in preterm neonates is associated with end-organ injury including intraventricular hemorrhage. Early treatment may reduce morbidities but may result in overtreatment. This study aimed to examine the association between commonly obtained echocardiographic markers within the first 12\u2009hours of life and eventual treatment of an hsPDA.<\/jats:p><jats:p>\n            Study Design Patients with &lt;32 weeks' gestational age had blinded echocardiograms done within the first 12\u2009hours of life as part of research protocols. Subsequent treatment of the patent ductus arteriosus (PDA) was determined by the clinical team independent of echocardiogram results. t-tests and chi-square tests were done for continuous data and categorical outcomes. A receiver operating curve was created to optimize cutoff values.<\/jats:p><jats:p>\n            Results\u2003Among 199 neonates studied (mean time of echocardiogram 6.7\u2009h after birth), those needing PDA treatment had higher left ventricular output (LVO), right ventricular output (RVO), and superior vena cava (SVC) flow (p-values 0.007, 0.044, and 0.012, respectively). Cutoffs for predicting PDA treatment were LVO\u2009&gt;\u2009204 mL\/kg\/min (63% sensitivity, 66% specificity), RVO\u2009&gt;\u2009221 mL\/kg\/min or SVC flow\u2009&gt;\u200999 mL\/kg\/min (sensitivities 70 and 43%, specificities 48 and 73%, respectively).<\/jats:p><jats:p>\n            Conclusion\u2003Preterm neonates with higher markers of cardiac output in the first 12\u2009hours of birth later required PDA treatment. These data are the first to use standard cardiac output measures in the first 12\u2009hours of life to predict the need for future PDA treatment. Further prospective studies will need to be performed to corroborate these associations between echocardiographic markers and clinical outcomes\/morbidities.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2249-1671","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T23:51:50Z","timestamp":1705621910000},"page":"1673-1679","source":"Crossref","is-referenced-by-count":0,"title":["Early Echocardiographic Predictors of Eventual Need for Patent Ductus Arteriosus Treatment: A Retrospective Study"],"prefix":"10.1055","volume":"41","author":[{"given":"Jenny","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Sharp Mary Birch Hospital for Women and Newborns, Sharp Neonatal Research Institute, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nohemi","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Sharp Mary Birch Hospital for Women and Newborns, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anup","family":"Katheria","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Sharp Mary Birch Hospital for Women and Newborns, Sharp Neonatal Research Institute, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"e20201209","DOI":"10.1542\/peds.2020-1209","article-title":"Patent ductus arteriosus of the preterm infant","volume":"146","author":"S EG Hamrick","year":"2020","journal-title":"Pediatrics"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"e20164258","DOI":"10.1542\/peds.2016-4258","article-title":"Spontaneous closure of patent ductus arteriosus in infants \u22641500\u2009g","volume":"140","author":"J Semberova","year":"2017","journal-title":"Pediatrics"},{"issue":"01","key":"ref3","first-page":"47","article-title":"Patent ductus arteriosus clinical trials: lessons learned and future directions","volume":"8","author":"A Smith","year":"2021","journal-title":"Children (Basel)"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1038\/s41372-019-0496-5","article-title":"Duration of significant patent ductus arteriosus and bronchopulmonary dysplasia in extremely preterm infants","volume":"39","author":"H Mirza","year":"2019","journal-title":"J Perinatol"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41390-021-01475-w","article-title":"Patent ductus arteriosus, tracheal ventilation, and the risk of bronchopulmonary dysplasia","volume":"91","author":"R I Clyman","year":"2022","journal-title":"Pediatr 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