{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:30:22Z","timestamp":1730871022588,"version":"3.28.0"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die axiale Spondyloarthritis (axSpA) ist eine entz\u00fcndlich-rheumatische Erkrankung, die typischerweise durch entz\u00fcndlichen R\u00fcckenschmerz (eRs) gekennzeichnet ist. Der Terminus axSpA hat den lange gebr\u00e4ulichen Begriff ankylosierende Spondylitis (AS) weitgehend abgel\u00f6st. Der eRs ist durch Entz\u00fcndung im Achsenskelett bedingt, wobei die Sakroiliakalgelenke (SIG) initial besonders h\u00e4ufig betroffen sind. Meist in sp\u00e4teren Stadien kommt die Wirbels\u00e4ule hinzu, was strukturell dann zunehmend durch Knochenneubildung gekennzeichnet ist. Zum Gesamktonzept der Spondyloarthritiden geh\u00f6ren weitere Krankheitsmanifestationen wie Uveitis, Psoriasis und Colitis und Komorbidit\u00e4ten wie kardiovaskul\u00e4re Erkrankungen und Osteoporose.<\/jats:p><jats:p>F\u00fcr die axSpA gibt es seit 2009 die ASAS-Klassifikationskriterien, die die 1984 modifizierten New York-Kriterien abgel\u00f6st haben. Bei ersteren spielen \u00fcber das konventionelle R\u00f6ntgen hinaus erstmals mit Magnetresonanztomographie (MRT) festgestellte Ver\u00e4nderungen in der Bildgebung der SIG und auch der Nachweis von HLA B27 eine Rolle. Wichtig ist, dass es sich nicht um diagnostische Kriterien handelt, denn die gibt es nicht. In dieser Arbeit werden 10 Punkte aufgezeigt, die bei der Diagnosestellung ber\u00fccksichtigt werden sollten.<\/jats:p>","DOI":"10.1055\/a-2251-6876","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T23:52:02Z","timestamp":1713225122000},"page":"513-520","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostik und Klassifikation der axialen Spondyloarthritis (axSpA) \u2013 der aktuelle Stand"],"prefix":"10.1055","volume":"149","author":[{"given":"J\u00fcrgen","family":"Braun","sequence":"additional","affiliation":[{"name":"RVZ Steglitz, Berlin, und Ruhr Universit\u00e4t Bochum, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Poddubnyy","sequence":"additional","affiliation":[{"name":"Rheumatologie am Campus Benjamin Franklin \u2013 Medizinische Klinik f\u00fcr Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","article-title":"Ankylosing spondylitis","volume":"369","author":"J Braun","year":"2007","journal-title":"Lancet"},{"key":"ref2","first-page":"39073","article-title":"Axial spondyloarthritis","author":"J Sieper","year":"2017","journal-title":"Lancet"},{"issue":"S 04","key":"ref3","doi-asserted-by":"crossref","first-page":"iv47","DOI":"10.1093\/rheumatology\/keaa246","article-title":"Prevalence and impact of comorbidities in axial spondyloarthritis: systematic review and meta-analysis","volume":"59","author":"S S Zhao","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.7326\/M14-2470","article-title":"Patients With Ankylosing Spondylitis Have Increased Cardiovascular and Cerebrovascular Mortality: A Population-Based Study","volume":"163","author":"N N Haroon","year":"2015","journal-title":"Ann Intern Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780370709","article-title":"Use of dynamic magnetic resonance imaging with fast imaging in the detection of early and advanced sacroiliitis in spondylarthropathy patients","volume":"37","author":"J Braun","year":"1994","journal-title":"Arthritis Rheum"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0140-6736(02)08215-6","article-title":"Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial","volume":"359","author":"J Braun","year":"2002","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria","volume":"27","author":"S van der Linden","year":"1984","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/ard.2009.108233","article-title":"The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection","volume":"68","author":"M Rudwaleit","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3899\/jrheum.130959","article-title":"Classification and diagnosis of axial spondyloarthritis \u2013 what is the clinically relevant difference?","volume":"42","author":"J Braun","year":"2015","journal-title":"J Rheumatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1093\/rheumatology\/kez090","article-title":"Determinants of diagnostic delay in axial spondyloarthritis: an analysis based on linked claims and patient-reported survey data","volume":"58","author":"I Redeker","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224232","article-title":"ASAS consensus definition of early axial spondyloarthritis","author":"V Navarro-Comp\u00e1n","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s11926-013-0374-7","article-title":"Spondyloarthritis with onset after age 45","volume":"15","author":"I Olivieri","year":"2013","journal-title":"Curr Rheumatol Rep"},{"key":"ref13","first-page":"415","article-title":"Frequencies of musculoskeletal symptoms and disorders in the population-based German National Cohort (GNC)","volume":"63","author":"C O Schmidt","year":"2020","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1136\/ard.2009.110767","article-title":"Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS\/OMERACT MRI group","volume":"68","author":"M Rudwaleit","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1136\/ard.2011.150680","article-title":"Assessment in SpondyloArthritis international Society (ASAS). Descriptions of spinal MRI lesions and definition of a positive MRI of the spine in axial spondyloarthritis: a consensual approach by the ASAS\/OMERACT MRI study group","volume":"71","author":"K G Hermann","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1136\/annrheumdis-2019-215589","article-title":"MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group","volume":"78","author":"W P Maksymowych","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-222081","article-title":"MRI lesions of the spine in patients with axial spondyloarthritis: an update of lesion definitions and validation by the ASAS MRI working group","author":"X Baraliakos","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/annrheumdis-2019-215553","article-title":"Frequency of MRI changes suggestive of axial spondyloarthritis in the axial skeleton in a large population-based cohort of individuals aged <45 years","volume":"79","author":"X Baraliakos","journal-title":"Ann Rheum Dis 2020"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/art.40475","article-title":"Magnetic Resonance Imaging of the Sacroiliac Joints Indicating Sacroiliitis According to the Assessment of SpondyloArthritis international Society Definition in Healthy Individuals, Runners, and Women With Postpartum Back Pain","volume":"70","author":"J de Winter","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1093\/rheumatology\/keaa175","article-title":"Clinical and imaging characteristics of osteitis condensans ilii as compared with axial spondyloarthritis","volume":"59","author":"D Poddubnyy","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1002\/art.24024","article-title":"Severity of baseline magnetic resonance imaging-evident sacroiliitis and HLA-B27 status in early inflammatory back pain predict radiographically evident ankylosing spondylitis at eight years","volume":"58","author":"A N Bennett","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/art.41595","article-title":"Which Magnetic Resonance Imaging Lesions in the Sacroiliac Joints Are Most Relevant for Diagnosing Axial Spondyloarthritis? 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Results from eight cohorts","volume":"78","author":"A Boel","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1136\/annrheumdis-2014-205178","article-title":"Higher disease activity leads to more structural damage in the spine in ankylosing spondylitis: 12-year longitudinal data from the OASIS cohort","volume":"73","author":"S Ramiro","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/rheumatology\/kead532","article-title":"Why are the classification and diagnosis of axial spondyloarthritis sometimes so difficult?","volume":"63","author":"J Braun","year":"2023","journal-title":"Rheumatology (Oxford)"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e002302","DOI":"10.1136\/rmdopen-2022-002302","article-title":"Heterogeneity of axial spondyloarthritis: genetics, sex and structural damage matter","volume":"8","author":"Z Li","year":"2022","journal-title":"RMD Open"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.berh.2009.12.005","article-title":"What is the prognosis of back pain?","volume":"24","author":"J A Hayden","year":"2010","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1007\/s00393-021-01019-x","article-title":"Entwicklung von Qualit\u00e4tsstandards f\u00fcr Patient*innen mit axialer Spondyloarthritis zum Einsatz in Deutschland","volume":"81","author":"U Kiltz","year":"2022","journal-title":"Z Rheumatol"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2251-6876.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T17:15:18Z","timestamp":1730826918000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2251-6876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":43,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2024,4,15]]},"published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2251-6876","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"type":"print","value":"0012-0472"},{"type":"electronic","value":"1439-4413"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}