{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T15:27:37Z","timestamp":1749655657462,"version":"3.37.3"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background Extracorporeal shockwave lithotripsy (ESWL) and\/or endoscopic retrograde cholangiopancreatography (ERCP) are recommended as first-line therapy for painful uncomplicated chronic pancreatitis with obstructed main pancreatic duct (MPD) in the pancreas head\/body. However, predictors of pain relief after ESWL are unknown. We evaluated independent predictors of persistent pain in patients who underwent ESWL for chronic pancreatitis.<\/jats:p><jats:p>\n            Methods 640 consecutive adult patients with chronic pancreatitis, who underwent successful ESWL with ERCP and pancreatic duct (PD) stent placement, were followed for 12 months. The pain was assessed at baseline and at 12 months using the Izbicki Pain Score, with a score decrease of &gt;50% considered pain relief. Independent predictors of pain relief were derived from logistic regression analysis.<\/jats:p><jats:p>\n            Results Of 640 patients (mean age 36.71 [SD 12.19] years; 60.5% men), 436 (68.1%) had pain relief and 204 (31.9%) had persistent pain. On univariate analysis, older age, male sex, alcohol and tobacco intake, longer duration of symptoms, dilated MPD and MPD stricture were associated with persistent pain at 12 months (P&lt;0.05). Consumption of alcohol (odds ratio [OR] 1.93, 95%CI 1.26\u20132.97), tobacco (OR 4.09, 95%CI 2.43\u20136.90), duration of symptoms (OR 1.02, 95%CI 1.01\u20131.04), MPD size (OR 1.22, 95%CI 1.11\u20131.33), and MPD stricture (OR 8.50, 95%CI 5.01\u201314.42) were independent predictors of persistent pain.<\/jats:p><jats:p>\n            Conclusions Alcohol, tobacco, duration of symptoms, MPD size and stricture were independent predictors of persistent pain after successful ESWL. A multidisciplinary team approach that includes behavioral therapy and surgical options should be considered for such patients.<\/jats:p>","DOI":"10.1055\/a-2252-9920","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:19:16Z","timestamp":1706141956000},"page":"406-411","source":"Crossref","is-referenced-by-count":10,"title":["Predictors of persistent pain after extracorporeal shockwave lithotripsy for painful chronic calcific pancreatitis"],"prefix":"10.1055","volume":"56","clinical-trial-number":[{"clinical-trial-number":"nct04490083","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Nitish","family":"Gurav","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-0164","authenticated-orcid":false,"given":"Nitin","family":"Jagtap","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Koppoju","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Sekhramantri","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-779X","authenticated-orcid":false,"given":"Shujaath","family":"Asif","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manu","family":"Tandan","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-9209","authenticated-orcid":false,"given":"Sundeep","family":"Lakhtakia","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Kalapala","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Ramchandani","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupjyoti","family":"Talukdar","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5621-6228","authenticated-orcid":false,"given":"Jahangeer","family":"Basha","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-4781","authenticated-orcid":false,"given":"Zaheer","family":"Nabi","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana Fatima","family":"Memon","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Darisetty","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Anaesthesia, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guduru Venkat","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Nageshwar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, AIG Hospitals, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.pan.2019.08.001","article-title":"ESWL for large pancreatic calculi: report of over 5000 patients","volume":"19","author":"M Tandan","year":"2019","journal-title":"Pancreatology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/nrgastro.2011.274","article-title":"Unraveling the mystery of pain in chronic pancreatitis","volume":"9","author":"PJ Pasricha","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1136\/gut.2010.213835","article-title":"Type of pain, pain-associated complications, quality of life, disability and resource utilisation in chronic pancreatitis: a prospective cohort study","volume":"60","author":"DK Mullady","year":"2011","journal-title":"Gut"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1097\/MPA.0000000000000616","article-title":"Clinical profile, etiology, and treatment of chronic pancreatitis in North American women: analysis of a large multicenter cohort","volume":"45","author":"J Romagnuolo","year":"2016","journal-title":"Pancreas"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1055\/a-0822-0832","article-title":"Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline \u2013 updated August 2018","volume":"51","author":"JM Dumonceau","year":"2019","journal-title":"Endoscopy"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/MPA.0000000000000464","article-title":"Extracorporeal shock wave lithotripsy for Chinese patients with pancreatic stones: a prospective study of 214 cases","volume":"45","author":"LH Hu","year":"2016","journal-title":"Pancreas"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/MPA.0000000000000277","article-title":"Efficacy of stone density on noncontrast computed tomography in predicting the outcome of extracorporeal shock wave lithotripsy for patients with pancreatic stones","volume":"44","author":"H Ohyama","year":"2015","journal-title":"Pancreas"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.gie.2012.01.014","article-title":"Long-term outcomes associated with pancreatic extracorporeal shock wave lithotripsy for chronic calcific pancreatitis","volume":"75","author":"G Seven","year":"2012","journal-title":"Gastrointest Endosc"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1136\/gut.2006.096883","article-title":"Treatment for painful calcified chronic pancreatitis: extracorporeal shock wave lithotripsy versus endoscopic treatment: a randomised controlled trial","volume":"56","author":"JM Dumonceau","year":"2007","journal-title":"Gut"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/s1542-3565(05)00530-6","article-title":"Long-term results of extracorporeal shockwave lithotripsy and endoscopic therapy for pancreatic stones","volume":"3","author":"H Tadenuma","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1080\/00365520510024098","article-title":"Interventional endoscopic therapy in chronic pancreatitis including temporary stenting: a definitive treatment?","volume":"41","author":"MJ Farnbacher","year":"2006","journal-title":"Scand J Gastroenterol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/s0016-5107(95)70049-8","article-title":"Endoscopic stenting for pain relief in chronic pancreatitis: results of a standardized protocol","volume":"42","author":"T Ponchon","year":"1995","journal-title":"Gastrointest Endosc"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"873","DOI":"10.5009\/gnl15555","article-title":"Management of pancreatic calculi: an update","volume":"10","author":"M Tandan","year":"2016","journal-title":"Gut Liver"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.giec.2023.04.006","article-title":"Management of pancreatic duct stones: extracorporeal approach","volume":"33","author":"M Tandan","year":"2023","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S1542-3565(04)00544-0","article-title":"Long-term clinical outcome after endoscopic pancreatic ductal drainage for patients with painful chronic pancreatitis","volume":"2","author":"M Delhaye","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0016-5107(96)70189-X","article-title":"Endoscopic pancreatic drainage in chronic pancreatitis associated with ductal stones: long-term results","volume":"43","author":"JM Dumonceau","year":"1996","journal-title":"Gastrointest Endosc"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"6884","DOI":"10.3748\/wjg.v23.i37.6884","article-title":"Prognostic factors of response to endoscopic treatment in painful chronic pancreatitis","volume":"23","author":"A Tantau","year":"2017","journal-title":"World J Gastroenterol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1097\/01.mcg.0000180799.18834.99","article-title":"Outcome following endoscopic stenting of pancreatic duct strictures in chronic pancreatitis","volume":"39","author":"M Topazian","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"E1595","DOI":"10.1055\/a-1006-2658","article-title":"Multiple stents are not superior to single stent insertion for pain relief in patients with chronic pancreatitis: a retrospective comparative study","volume":"7","author":"L Papalavrentios","year":"2019","journal-title":"Endosc Int Open"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1067\/mge.2002.128162","article-title":"Pancreatic duct stones in chronic pancreatitis: criteria for treatment intensity and success","volume":"56","author":"MJ Farnbacher","year":"2002","journal-title":"Gastrointest Endosc"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/j.1572-0241.2007.01350.x","article-title":"Mechanical lithotripsy of pancreatic and biliary stones: complications and available treatment options collected from expert centers","volume":"102","author":"M Thomas","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1080\/00365521.2016.1209688","article-title":"Efficacy and safety of extracorporeal shock wave lithotripsy for chronic pancreatitis","volume":"51","author":"T Vaysse","year":"2016","journal-title":"Scand J Gastroenterol"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2252-9920.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:40:27Z","timestamp":1730824827000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2252-9920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":22,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2024,5,29]]},"published-print":{"date-parts":[[2024,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2252-9920","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"type":"print","value":"0013-726X"},{"type":"electronic","value":"1438-8812"}],"subject":[],"published-other":{"date-parts":[[2024,1,24]]},"published":{"date-parts":[[2024,1,24]]}}}