{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:53:16Z","timestamp":1789595596411,"version":"build-2803163510"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Reconstr Microsurg"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003A comprehensive understanding of changes in health-related quality of life after head and neck cancer surgery is necessary for effective preoperative counseling. The goal of this study was to perform a longitudinal analysis of postoperative quality of life outcomes after fibula free flap (FFF) mandible reconstruction.<\/jats:p><jats:p>\n          Methods\u2003A retrospective review was performed for all patients who underwent oncologic mandible reconstruction with an FFF between 2000 and 2021. Completion of at least one postoperative FACE-Q questionnaire was necessary for inclusion. FACE-Q scores were divided into five time periods for analysis. Functional outcomes measured with speech language pathology (SLP) assessments and tracheostomy and gastrostomy tube status were analyzed at three time points.<\/jats:p><jats:p>\n          Results\u2003One hundred and nine patients were included. Of these, 68 patients also had at least one SLP assessment. All outcomes as measured by the various FACE-Q scales did not improve significantly from the immediate postoperative time point to the last evaluated time point (p\u2009&gt;\u20090.05). SLP functional outcomes showed some deterioration over time, but these were not significant (p\u2009&gt;\u20090.05). The percentage of patients who required a tracheostomy (18 to 2%, p\u2009=\u20090.002) or gastrostomy tube (25 to 11%, p\u2009=\u20090.035) decreased significantly from the immediate postoperative time point to the last evaluated time point.<\/jats:p><jats:p>\n          Conclusion\u2003Subjective quality of life outcomes do not change significantly with time after oncologic FFF mandible reconstruction. Reconstructive surgeons can use these results to help patients establish appropriate and achievable quality of life goals after surgery. Further studies are warranted to elucidate the impact of specific relevant clinical variables on postoperative quality of life.<\/jats:p>","DOI":"10.1055\/a-2253-6208","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:22:45Z","timestamp":1706142165000},"page":"578-588","source":"Crossref","is-referenced-by-count":5,"title":["Quality of Life Outcomes after Free Fibula Flap Reconstruction of Mandibular Defects: A Longitudinal Examination"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-4221","authenticated-orcid":false,"given":"Kevin K.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zack","family":"Cohen","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Speech Pathology, Center for Speech and Hearing, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minji","family":"Kim","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Monge","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tecce","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Cracchiolo","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Matros","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farooq","family":"Shahzad","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Robert J.","family":"Allen","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00006534-198907000-00014","article-title":"Fibula free flap: a new method of mandible reconstruction","volume":"84","author":"D A Hidalgo","year":"1989","journal-title":"Plast Reconstr Surg"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1097\/00006534-199910000-00011","article-title":"Reconstruction of the mandible with osseous free flaps: a 10-year experience with 150 consecutive patients","volume":"104","author":"P G Cordeiro","year":"1999","journal-title":"Plast Reconstr Surg"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1054\/jcms.2000.0122","article-title":"Comparisons of bone volumes and densities relating to osseointegrated implants in microvascularly reconstructed mandibles: a study of cadaveric radius and fibula bones","volume":"28","author":"B Klesper","year":"2000","journal-title":"J Craniomaxillofac Surg"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1055\/s-2007-1006703","article-title":"The osteocutaneous fibula flap: an anatomic study","volume":"8","author":"M Beppu","year":"1992","journal-title":"J Reconstr Microsurg"},{"key":"ref5","first-page":"233","volume-title":"Peroneal vessels","author":"N T Haddock","year":"2021"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/00006534-199110000-00003","article-title":"Aesthetic improvements in free-flap mandible reconstruction","volume":"88","author":"D A Hidalgo","year":"1991","journal-title":"Plast Reconstr Surg"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/00006534-199211000-00008","article-title":"The osteocutaneous free fibula flap: is the skin paddle reliable?","volume":"90","author":"M A Schusterman","year":"1992","journal-title":"Plast Reconstr Surg"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/cid.12870","article-title":"Immediate dental implants in fibula free flaps to reconstruct the mandible: a pilot study of the short-term effects on radiotherapy for patients with head and neck cancer","volume":"22","author":"M L Sandoval","year":"2020","journal-title":"Clin Implant Dent Relat Res"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/019459988910100111","article-title":"Primary placement of osseointegrated implants in microvascular mandibular reconstruction","volume":"101","author":"M L Urken","year":"1989","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/PRS.0b013e318221dc2a","article-title":"A prospective cohort study of fibula free flap donor-site morbidity in 157 consecutive patients","volume":"128","author":"A O Momoh","year":"2011","journal-title":"Plast Reconstr Surg"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/00006534-199507000-00022","article-title":"Donor leg morbidity and function after fibula free flap mandible reconstruction","volume":"96","author":"J P Anthony","year":"1995","journal-title":"Plast Reconstr Surg"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"1007e","DOI":"10.1097\/PRS.0000000000008588","article-title":"Patient-reported outcomes after fibula free flap harvest: a pilot study","volume":"148","author":"A C Hatchell","year":"2021","journal-title":"Plast Reconstr Surg"},{"issue":"07","key":"ref13","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1002\/hed.25666","article-title":"Long-term functional and esthetic outcomes after fibula free flap reconstruction of the mandible","volume":"41","author":"I Petrovic","year":"2019","journal-title":"Head Neck"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"768e","DOI":"10.1097\/PRS.0000000000007352","article-title":"Short-term outcomes following virtual surgery-assisted immediate dental implant placement in free fibula flaps for oncologic mandibular reconstruction","volume":"146","author":"R J Allen Jr","year":"2020","journal-title":"Plast Reconstr Surg"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1097\/SCS.0b013e3181e1b5d8","article-title":"Importance of computer-aided design and manufacturing technology in the multidisciplinary approach to head and neck reconstruction","volume":"21","author":"B Sharaf","year":"2010","journal-title":"J Craniofac Surg"},{"issue":"05","key":"ref16","first-page":"289","article-title":"Computer-assisted design and computer-assisted modeling technique optimization and advantages over traditional methods of osseous flap reconstruction","volume":"30","author":"E Matros","year":"2014","journal-title":"J Reconstr Microsurg"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1097\/PRS.0000000000002766","article-title":"Health-related quality of life following reconstruction for common head and neck surgical defects","volume":"138","author":"W A Cohen","year":"2016","journal-title":"Plast Reconstr Surg"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1054\/bjom.2001.0706","article-title":"Health-related quality of life and clinical function after primary surgery for oral cancer","volume":"40","author":"S N Rogers","year":"2002","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"03","key":"ref19","first-page":"120","article-title":"Quality of life in patients treated for cancer of the oral cavity requiring reconstruction: a prospective study","volume":"28","author":"A B Villaret","year":"2008","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"06","key":"ref20","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/cncr.31900","article-title":"Leveraging patient-reported outcomes data to inform oncology clinical decision making: Introducing the FACE-Q Head and Neck Cancer Module","volume":"125","author":"J R Cracchiolo","year":"2019","journal-title":"Cancer"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.otohns.2006.12.006","article-title":"A systematic review of patient-reported outcome measures in head and neck cancer surgery","volume":"136","author":"A Pusic","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1586\/erp.11.105","article-title":"Measuring and managing patient expectations for breast reconstruction: impact on quality of life and patient satisfaction","volume":"12","author":"A L Pusic","year":"2012","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"issue":"02","key":"ref23","doi-asserted-by":"crossref","first-page":"212e","DOI":"10.1097\/PRS.0b013e31829586fa","article-title":"Optimizing patient-centered care in breast reconstruction: the importance of preoperative information and patient-physician communication","volume":"132","author":"A L Ho","year":"2013","journal-title":"Plast Reconstr Surg"},{"issue":"05","key":"ref24","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.joms.2022.11.016","article-title":"What risk factors are associated with poorer quality of life in patients with head and neck cancer?","volume":"81","author":"K Huang","year":"2023","journal-title":"J Oral Maxillofac Surg"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"101770","DOI":"10.1016\/j.ejon.2020.101770","article-title":"Symptom patterns, physical function and quality of life among head and neck cancer patients prior to and after surgical treatment: a prospective study","volume":"46","author":"Z Y Hu","year":"2020","journal-title":"Eur J Oncol Nurs"},{"issue":"08","key":"ref26","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s00520-013-1774-y","article-title":"Longitudinal quality of life in Turkish patients with head and neck cancer undergoing radiotherapy","volume":"21","author":"E Citak","year":"2013","journal-title":"Support Care Cancer"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.coms.2018.06.006","article-title":"Oral assessment and management of the patient with head and neck cancer","volume":"30","author":"H Y Sroussi","year":"2018","journal-title":"Oral Maxillofac Surg Clin North Am"},{"issue":"07","key":"ref28","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/lary.25894","article-title":"Swallowing outcomes following primary surgical resection and primary free flap reconstruction for oral and oropharyngeal squamous cell carcinomas: a systematic review","volume":"126","author":"S S Kao","year":"2016","journal-title":"Laryngoscope"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/PRS.0000000000007077","article-title":"Dental implant survival in vascularized bone flaps: a systematic review and meta-analysis","volume":"146","author":"H Panchal","year":"2020","journal-title":"Plast Reconstr Surg"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1600-0501.2011.02368.x","article-title":"A comparison of implant-retained mandibular overdentures and conventional dentures on quality of life in edentulous patients: a randomized, prospective, within-subject controlled clinical trial","volume":"24","author":"D Harris","year":"2013","journal-title":"Clin Oral Implants Res"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s40729-021-00373-4","article-title":"Clinical long-term and patient-reported outcomes of dental implants in oral cancer patients","volume":"7","author":"E Schiegnitz","year":"2021","journal-title":"Int J Implant Dent"},{"issue":"02","key":"ref32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/a-2070-8677","article-title":"Miniplate versus reconstruction bar fixation for oncologic mandibular reconstruction with free fibula flaps","volume":"40","author":"Z Cohen","year":"2024","journal-title":"J Reconstr Microsurg"},{"issue":"03","key":"ref33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-0042-1755260","article-title":"The cost utility of virtual surgical planning and computer-assisted design\/computer-assisted manufacturing in mandible reconstruction using the free fibula osteocutaneous flap","volume":"39","author":"D E Kurlander","year":"2023","journal-title":"J Reconstr Microsurg"},{"issue":"09","key":"ref34","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.bjoms.2015.07.008","article-title":"Longitudinal evaluation of health-related quality of life after osteoradionecrosis of the mandible","volume":"53","author":"S N Rogers","year":"2015","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"08","key":"ref35","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.joms.2014.02.018","article-title":"Quality of life assessment in patients after mandibular resection and free fibula flap reconstruction","volume":"72","author":"L Zavalishina","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"issue":"02","key":"ref36","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1055\/s-0037-1606537","article-title":"Quality of life after free fibula flap reconstruction of segmental mandibular defects","volume":"34","author":"J L\u00f6fstrand","year":"2018","journal-title":"J Reconstr Microsurg"},{"issue":"09","key":"ref37","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.ijom.2007.04.013","article-title":"Clinical outcome and patient satisfaction after mandibular reconstruction with free fibula flaps","volume":"36","author":"F H\u00f6lzle","year":"2007","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"11e","DOI":"10.1097\/PRS.0000000000006317","article-title":"Giving meaning to differences in BREAST-Q scores: minimal important difference for breast reconstruction patients","volume":"145","author":"S H Voineskos","year":"2020","journal-title":"Plast Reconstr Surg"}],"container-title":["Journal of Reconstructive Microsurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2253-6208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:39:59Z","timestamp":1730824799000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2253-6208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":38,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2024,9,12]]},"published-print":{"date-parts":[[2024,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2253-6208","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0743-684X","1098-8947"],"issn-type":[{"value":"0743-684X","type":"print"},{"value":"1098-8947","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,24]]},"published":{"date-parts":[[2024,1,24]]}}}