{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:23Z","timestamp":1787004863286,"version":"build-2736575974"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Objective\u2003No available scale, at the time of initial evaluation for necrotizing enterocolitis (NEC), accurately predicts, that is, with an area under the curve (AUC) \u22650.9, which preterm infants will undergo surgery for NEC stage III or die within a week.<\/jats:p>\n                  <jats:p>Study Design\u2003This is a retrospective cohort study (n\u2009=\u2009261) of preterm infants with &lt;33 weeks' gestation or &lt;1,500\u2009g birth weight with either suspected or with definite NEC born at Parkland Hospital between 2009 and 2021. A prediction model using the new HASOFA score (Hyperglycemia, Hyperkalemia, use of inotropes for Hypotension during the prior week, Acidemia, Neonatal Sequential Organ Failure Assessment [nSOFA] score) was compared with a similar model using the nSOFA score.<\/jats:p>\n                  <jats:p>Results\u2003Among 261 infants, 112 infants had NEC stage I, 68 with NEC stage II, and 81 with NEC stage III based on modified Bell's classification. The primary outcome, surgery for NEC stage III or death within a week, occurred in 81 infants (surgery in 66 infants and death in 38 infants). All infants with pneumoperitoneum or abdominal compartment syndrome either died or had surgery. The HASOFA and the nSOFA scores were evaluated in 254 and 253 infants, respectively, at the time of the initial workup for NEC. Both models were internally validated. The HASOFA model was a better predictor of surgery for NEC stage III or death within a week than the nSOFA model, with greater AUC 0.909 versus 0.825, respectively, p\u2009&lt;\u20090.001. Combining HASOFA at initial assessment with concurrent or later presence of abdominal wall erythema or portal gas improved the prediction surgery for NEC stage III or death with AUC 0.942 or 0.956, respectively.<\/jats:p>\n                  <jats:p>Conclusion\u2003Using this new internally validated prediction model, surgery for NEC stage III or death within a week can be accurately predicted at the time of initial assessment for NEC.<\/jats:p>\n                  <jats:p>Key Points<\/jats:p>","DOI":"10.1055\/a-2253-8656","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T18:45:11Z","timestamp":1706208311000},"page":"1714-1727","source":"Crossref","is-referenced-by-count":7,"title":["Development of a Prediction Model for Surgery or Early Mortality at the Time of Initial Assessment for Necrotizing Enterocolitis"],"prefix":"10.1055","volume":"41","author":[{"given":"Sujir P.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"S\u00e1nchez-Rosado","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Division of Neonatology, Joe DiMaggio Children's Hospital, Hollywood, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan D.","family":"Reis","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Department of Pediatrics, Baylor Scott and White, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Steven","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Research, Parkland Health and Hospital System, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate L.","family":"Mangona","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Department of Pediatrics, Baylor Scott and White, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, and Parkland Health, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra H.","family":"Wyckoff","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Pandya","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran N.","family":"Mir","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc P.","family":"Brion","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, 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