{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:51:33Z","timestamp":1752231093389,"version":"3.37.3"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Reconstr Microsurg"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Microsurgical breast reconstruction after mastectomy is now the standard of care for breast cancer patients. However, the costs and resources involved in free flap reconstruction can vary across different medical settings. To enhance patient outcomes in a cost-effective manner, we investigated the effect of intravenous magnesium sulfate (IV Mg) on postoperative opioid usage in this context.<\/jats:p><jats:p>\n          Methods\u2003A retrospective chart review was performed on all consecutive patients who underwent abdominal-based free flap breast reconstruction in a single institute following an enhanced recovery after surgery (ERAS) protocol. Patients who received IV Mg were compared with those who did not receive supplementation. Serum magnesium levels at different time points, narcotic consumption in units of oral morphine milligram equivalents (MMEs), and other postoperative recovery parameters were compared.<\/jats:p><jats:p>\n          Results\u2003Eighty-two patients were included. Those who received IV Mg on postoperative day 0 (n\u2009=\u200967) showed significantly lower serum magnesium levels before repletion (1.5 vs. 1.7\u2009mg\/dL, p\u2009=\u20090.004) and significantly higher levels on postoperative day 1 after repletion (2.2 vs. 1.7\u2009mg\/dL, p\u2009=\u20090.0002) compared to patients who received no magnesium repletion (n\u2009=\u200913). While both groups required a similar amount of narcotics on postoperative day 0 (20.2 vs. 13.2 MMEs, p\u2009=\u20090.2), those who received IV Mg needed significantly fewer narcotics for pain control on postoperative day 1 (12.2 MMEs for IV Mg vs. 19.8 MMEs for No Mg, p\u2009=\u20090.03). Recovery parameters, including maximal pain scores, postoperative mobilization, and length of hospital stay, did not significantly differ between the two groups.<\/jats:p><jats:p>\n          Conclusion\u2003This is the first study to describe the potential analgesic benefits of routine postoperative magnesium repletion in abdominal-based free flap reconstruction. Further research is necessary to fully understand the role of perioperative magnesium supplementation as part of an ERAS protocol.<\/jats:p>","DOI":"10.1055\/a-2253-9008","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T23:46:56Z","timestamp":1706226416000},"page":"559-565","source":"Crossref","is-referenced-by-count":5,"title":["Postoperative Magnesium Sulfate Repletion Decreases Narcotic Use in Abdominal-Based Free Flap Breast Reconstruction"],"prefix":"10.1055","volume":"40","author":[{"given":"Yi-Hsueh","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Montefiore Medical Center, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jini","family":"Jeon","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-9523","authenticated-orcid":false,"given":"Yufan","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Montefiore Medical Center, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie E.","family":"Weichman","sequence":"additional","affiliation":[{"name":"Hansj\u00f6rg Wyss Department of Plastic Surgery, New York University Langone Health, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Northwell Health, Hofstra School of Medicine, Great Neck, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10549-018-4991-8","article-title":"Enhanced recovery after surgery (ERAS) pathways in breast reconstruction: systematic review and meta-analysis of the literature","volume":"173","author":"A C Offodile II","year":"2019","journal-title":"Breast Cancer Res Treat"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1056e","DOI":"10.1097\/PRS.0000000000003242","article-title":"Consensus review of optimal perioperative care in breast reconstruction: Enhanced Recovery after Surgery (ERAS) Society recommendations","volume":"139","author":"C Temple-Oberle","year":"2017","journal-title":"Plast Reconstr Surg"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.anclin.2022.04.002","article-title":"Multimodal 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