{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:56:11Z","timestamp":1765961771662,"version":"3.37.3"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"<jats:p>\n            Purpose\u2002With an incidence between 1\u20139\/100\u200a000 per year, Langerhans cell histiocytosis (LCH) is a rather rare disease from the hemato-oncologic disease spectrum (Hayes et al. 2009). The tumorlike disease with proliferation of histiocytic cells may manifest as localized to one organ or disseminated with infiltration of a wide variety of organs. Approximately 25\u201330\u200a% of these cases show involvement of the temporal bone (Ni et al. 2017).<\/jats:p><jats:p>\n            Case Description\u2002With vertigo persisting for three years, chronic mastoiditis, and acute progressive hearing loss bilaterally (r &gt; l) for three weeks, a 41-year-old woman presented at an emergency department. The DVT showed extensive bony destruction of large parts of the temporal bone on both sides, involving the vestibular organ, the cochlea, and the internal auditory canal. To confirm the suspicion of a systemic inflammatory process, a PE was performed from the mastoid with bioptic confirmation of an LCH. Systemic therapy was initiated. Post-therapeutic imaging showed almost complete remission with reossification of the preexisting defect zones and the internal auditory canal and labyrinth structures again showed bony margins. Clinically, there was an improvement of the vegetative symptoms with remaining bilateral sensorineural hearing loss.<\/jats:p><jats:p>\n            Discussion\u2002LCH of the temporal bone is a rare and often misdiagnosed disease due to its nonspecific clinical presentation. Awareness of temporal bone LCH and its occurrence in adults is essential for accurate and consistent diagnosis.<\/jats:p><jats:p>\n            Key Points:\u2002<\/jats:p>","DOI":"10.1055\/a-2254-5536","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:35:35Z","timestamp":1708389335000},"source":"Crossref","is-referenced-by-count":2,"title":["Langerhans cell histiocytosis involving the temporal bone with destruction and subsequent reossification of the bony labyrinth boundaries"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-8906","authenticated-orcid":false,"given":"Katja","family":"D\u00f6ring","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Ivanyi","sequence":"additional","affiliation":[{"name":"Clinic for Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-6781","authenticated-orcid":false,"given":"Heinrich","family":"Lanfermann","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasia","family":"Warnecke","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Giesemann","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4103\/0973-029X.99077","article-title":"Pathophysiology of Langerhans cells","volume":"16","author":"S Jaitley","year":"2012","journal-title":"J Oral Maxillofac Pathol"},{"issue":"01","key":"ref2","first-page":"1","article-title":"A case of Langerhans\u2019 cell histiocytosis of the temporal bone masquerading as acute mastoiditis","volume":"12","author":"S Hayes","year":"2009","journal-title":"Internet J Otorhinolaryngol"},{"issue":"03","key":"ref3","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.3892\/etm.2017.4072","article-title":"Langerhans\u2019 cell histiocytosis of the temporal bone: a case report","volume":"13","author":"M Ni","year":"2017","journal-title":"Exp Ther 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