{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:26:42Z","timestamp":1730870802400,"version":"3.28.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intraportal islet transplantation in patients with type 1 diabetes enables\n                    restoration of glucose-regulated insulin secretion. However, several factors\n                    hamper a widespread application and long-term success: chronic hypoxia, an\n                    inappropriate microenvironment and suppression of regenerative and proliferative\n                    potential by high local levels of immunosuppressive agents. Therefore, the\n                    identification of alternative and superior transplant sites is of major\n                    scientific and clinical interest. Here, we aim to evaluate the adrenal as an\n                    alternative transplantation site. The adrenal features a particular\n                    microenvironment with extensive vascularization, anti-apoptotic and\n                    pro-proliferative, anti-inflammatory and immunosuppressive effects. To validate\n                    this novel transplantation site, an in vitro co-culture system of adrenal cells\n                    and pancreatic islets was established and viability, islet survival, functional\n                    potency and antioxidative defense capacity were evaluated. For in vivo\n                    validation, an immune-deficient diabetic mouse model for intra-adrenal islet\n                    transplantation was applied. The functional capacity of intra-adrenally grafted\n                    islets to reverse diabetes was compared to a standard islet transplant model and\n                    measures of engraftment such as vascular integration were evaluated. The\n                    presence of adrenal cells positively impacted on cell metabolism and oxidative\n                    stress. Following transplantation, we could demonstrate enhanced islet function\n                    in comparison to standard models with improved engraftment and superior\n                    re-vascularization. This experimental approach allows for novel insights into\n                    the interaction of endocrine systems and may open up novel strategies for islet\n                    transplantation augmented through the bystander effect of other endocrine cells\n                    or the active factors secreted by adrenal cells modulating the\n                    microenvironment.<\/jats:p>","DOI":"10.1055\/a-2256-6344","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:04:00Z","timestamp":1710288240000},"page":"286-293","source":"Crossref","is-referenced-by-count":1,"title":["The Adrenal Gland and Pancreatic Islets \u2013 A Beneficial Endocrine\n                    Alliance"],"prefix":"10.1055","volume":"56","author":[{"given":"Undine","family":"Schubert","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus,\n                    Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the\n                    University Hospital Carl Gustav Carus and Faculty of Medicine of the Technische\n                    Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susann","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus,\n                    Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the\n                    University Hospital Carl Gustav Carus and Faculty of Medicine of the Technische\n                    Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus,\n                    Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the\n                    University Hospital Carl Gustav Carus and Faculty of Medicine of the Technische\n                    Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Morawietz","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus,\n                    Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Division of Vascular Endothelium and Microcirculation, Department of\n                    Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t\n                    Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan R.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus,\n                    Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the\n                    University Hospital Carl Gustav Carus and Faculty of Medicine of the Technische\n                    Universit\u00e4t Dresden, Dresden, Germany"},{"name":"School of Cardiovascular and Metabolic Medicine and Sciences,\n                    King's College London, Faculty of Life Sciences & Medicine, London,\n                    United Kingdom of Great Britain and Northern Ireland"},{"name":"Department of Endocrinology, Diabetology and Clinical Nutrition,\n                    University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich,\n                    Switzerland"},{"name":"Center for Regenerative Therapies, Technische Universit\u00e4t Dresden,\n                    Dresden, Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), Neuherberg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus,\n                    Technische Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Paul Langerhans Institute Dresden of the Helmholtz Center Munich at the\n                    University Hospital Carl Gustav Carus and Faculty of Medicine of the Technische\n                    Universit\u00e4t Dresden, Dresden, Germany"},{"name":"Center for Regenerative Therapies, Technische Universit\u00e4t Dresden,\n                    Dresden, Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), Neuherberg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00125-022-05804-4","article-title":"Factors associated with favourable 5 year outcomes in islet transplant alone\n                    recipients with type 1 diabetes complicated by severe hypoglycaemia in the\n                    Collaborative Islet Transplant Registry","volume":"66","author":"B J Hering","year":"2023","journal-title":"Diabetologia"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S2213-8587(23)00082-7","article-title":"Association between primary graft function and 5-year outcomes of islet\n                    allogeneic transplantation in type 1 diabetes: a retrospective, multicentre,\n                    observational cohort study in 1210 patients from the Collaborative Islet\n                    Transplant Registry","volume":"11","author":"M Chetboun","year":"2023","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"11950","DOI":"10.3389\/ti.2023.11950","article-title":"Primary graft function and 5 year insulin independence after pancreas and islet\n                    transplantation for type 1 diabetes: a retrospective parallel cohort study","volume":"36","author":"M Chetboun","year":"2023","journal-title":"Transpl Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s11892-011-0216-9","article-title":"Alternative transplantation sites for pancreatic islet grafts","volume":"11","author":"E Cantarelli","year":"2011","journal-title":"Curr Diab Rep"},{"volume-title":"Transplantation, bioengineering, and regeneration of the endocrine\n                    pancreas:","year":"2019","author":"G Orlando","key":"ref5"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1073\/pnas.1221505110","article-title":"Transplantation of pancreatic islets to adrenal gland is promoted by agonists of\n                    growth-hormone-releasing hormone","volume":"110","author":"U Schubert","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1055\/s-2006-948136","article-title":"Vascular-adrenal niche - Endothelial cell-mediated sensitization of human\n                    adrenocortical cells to angiotensin II","volume":"38","author":"I Ansurudeen","year":"2006","journal-title":"Horm Metab Res"},{"key":"ref8","first-page":"431","article-title":"Adrenomedullin and vascular endothelium growth factor genes are overexpressed in\n                    the regenerating rat adrenal cortex, and AM and VEGF reciprocally enhance their\n                    mRNA expression in cultured rat adrenocortical cells","volume":"16","author":"G Albertin","year":"2005","journal-title":"Int J Mol Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1055\/s-2007-978894","article-title":"The role of endothelial cell products in the regulation of adrenocortical\n                    function: Actions of endothelin, nitric oxide, adrenomedullin and PAMP","volume":"30","author":"J P Hinson","year":"1998","journal-title":"Horm Metab Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"12623","DOI":"10.1073\/pnas.1005098107","article-title":"Agonist of growth hormone-releasing hormone as a potential effector for survival\n                    and proliferation of pancreatic islets","volume":"107","author":"B Ludwig","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF02581331","article-title":"Islet isolation assessment in man and large animals","volume":"27","author":"C Ricordi","year":"1990","journal-title":"Acta Diabetol Lat"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.bjp.0705776","article-title":"Measuring reactive species and oxidative damage in vivo and in cell culture: How\n                    should you do it and what do the results mean?","volume":"142","author":"B Halliwell","year":"2004","journal-title":"Br J Pharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0300-9084(02)01369-X","article-title":"Mitochondrial reactive oxygen species in cell death signaling","volume":"84","author":"C Fleury","year":"2002","journal-title":"Biochimie"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00006676-200004000-00008","article-title":"Cell loss in isolated human islets occurs by apoptosis","volume":"20","author":"S Paraskevas","year":"2000","journal-title":"Pancreas"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and benefits for human health","author":"G Pizzino","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.taap.2018.09.014","article-title":"Regulatory crosstalk between the oxidative stress-related transcription factor\n                    Nfe2l2\/Nrf2 and mitochondria","volume":"359","author":"I Ryoo","year":"2018","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.2337\/diabetes.51.8.2561","article-title":"Preservation of human islet cell functional mass by anti-oxidative action of a\n                    novel SOD mimic compound","volume":"51","author":"R Bottino","year":"2002","journal-title":"Diabetes"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.2337\/diabetes.53.10.2559","article-title":"Response of human islets to isolation stress and the effect of antioxidant\n                    treatment","volume":"53","author":"R Bottino","year":"2004","journal-title":"Diabetes"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0006-2952(03)00494-5","article-title":"Apoptotic signal transduction pathways in diabetes","volume":"66","author":"T Mandrup-Poulsen","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1196\/annals.1288.005","article-title":"Beta cell death and protection","volume":"1005","author":"T Mandrup-Poulsen","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.2337\/diabetes.50.2007.S58","article-title":"\u03b2-cell apoptosis: Stimuli and signaling","volume":"50","author":"T Mandrup-Poulsen","year":"2001","journal-title":"Diabetes"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1600-6143.2006.01577.x","article-title":"Quantification of basal and stimulated ROS levels as predictors of islet potency\n                    and function","volume":"7","author":"B Armann","year":"2007","journal-title":"Am J Transplant"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e57844","DOI":"10.1371\/journal.pone.0057844","article-title":"Maintenance of Islet Morphology Is Beneficial for Transplantation Outcome in\n                    Diabetic Mice","volume":"8","author":"C L Rackham","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/ajt.15812","article-title":"Shielding islets with human amniotic epithelial cells enhances islet engraftment\n                    and revascularization in a murine diabetes model","volume":"20","author":"F Lebreton","year":"2020","journal-title":"Am J Transplant"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"eaar6294","DOI":"10.1126\/scitranslmed.aar6294","article-title":"Targeting pancreatic islet PTP1B improves islet graft revascularization and\n                    transplant outcomes","volume":"11","author":"H Figueiredo","year":"2019","journal-title":"Sci Transl Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s41574-019-0236-0","article-title":"Targeting PTP1B in islet grafts","volume":"15","author":"S Starling","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.2337\/db08-0814","article-title":"Revascularization of transplanted islets: Can it be Improved?","volume":"57","author":"M Brissova","year":"2008","journal-title":"Diabetes"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2256-6344.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:47:13Z","timestamp":1730810833000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2256-6344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,12]]},"references-count":27,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2024,4,11]]},"published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2256-6344","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"type":"print","value":"0018-5043"},{"type":"electronic","value":"1439-4286"}],"subject":[],"published":{"date-parts":[[2024,3,12]]}}}