{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:24:55Z","timestamp":1791473095763,"version":"4.3.4"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Magnetic resonance imaging in fetal alcohol spectrum disorder (FASD) children showed altered connectivity, suggesting underlying deficits in networks, which may be related to cognitive outcome. Functional connectivity has been of interest in neurophysiological research with quantitative electroencephalography (QEEG) as useful tool for measuring pathology, not detectable by normal EEG. The aim of this study was to investigate differences in the EEG interhemispheric coherence (ICoh) in children diagnosed with FASD compared with healthy controls and to relate the results to cognitive scores.<\/jats:p><jats:p>\n          Method\u2003Analysis of ICoh in 81 FASD children (4-Digit Code) compared with 31 controls. The children underwent cognitive assessment, and EEG was performed and used for analysis. Group comparisons and analysis of covariance interaction models were used to test for differences between FASD and controls but also to look for differences between FASD subgroups. Significant findings were correlated to cognitive scores.<\/jats:p><jats:p>\n          Results\u2003Lower ICoh was found in the frontal and temporal derivations in the FASD group. When comparing FASD subgroups, children with fetal alcohol syndrome had lower ICoh occipital. Reduced ICoh in the temporal alpha band was correlated with lower performance IQ in the FASD group.<\/jats:p><jats:p>\n          Conclusion\u2003Our findings could imply hypoconnectivity between the hemispheres with impact on cognition. We suggest that EEG coherence analysis could be a sensitive parameter in the detection of electrophysiological abnormalities in FASD with possible clinical relevance. These results may indicate that QEEG could be used as biomarker for FASD. However, further research is needed to determine the role of QEEG analysis in the diagnosis of FASD.<\/jats:p>","DOI":"10.1055\/a-2262-7781","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:03:05Z","timestamp":1707264185000},"page":"241-249","source":"Crossref","is-referenced-by-count":4,"title":["Reduced Interhemispheric Coherence and Cognition in Children with Fetal Alcohol Spectrum Disorder (FASD)\u2014A Quantitative EEG Study"],"prefix":"10.1055","volume":"55","author":[{"given":"Thorsten","family":"Gerstner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Regional Competence for Children with Prenatal Alcohol\/Drug Exposure, S\u00f8rlandet Hospital, Arendal, Norway"},{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Henning","sequence":"additional","affiliation":[{"name":"National Centre for Epilepsy, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gro","family":"L\u00f8haugen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Regional Competence for Children with Prenatal Alcohol\/Drug Exposure, S\u00f8rlandet Hospital, Arendal, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Skranes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Regional Competence for Children with Prenatal Alcohol\/Drug Exposure, S\u00f8rlandet Hospital, Arendal, Norway"},{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, 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