{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T19:54:28Z","timestamp":1768766068248,"version":"3.49.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective This study aimed to assess the diagnostic performance of\n                        99mTc-sestamibi SPECT\/CT and 18F-choline PET\/CT in\n                    detecting hyperfunctioning parathyroid glands in patients undergoing surgery for\n                    primary hyperparathyroidism (PHPT).<\/jats:p><jats:p>\n          Methods A retrospective analysis was conducted on patients who underwent\n                    PHPT-related surgery between April 2019 and May 2022. The study focused on\n                    patients undergoing either 99mTc-sestamibi SPECT\/CT (81 patients) or\n                        18F-choline PET\/CT (33 patients) scans before surgery to pinpoint\n                    hyperfunctioning parathyroid gland(s). In the majority of patients,\n                        18F-choline PET\/CT was performed after negative or inconclusive\n                    findings on 99mTc-sestamibi SPECT\/CT. Pathohistological reports were\n                    utilized as the reference standard for evaluating the accuracy of the imaging\n                    findings.<\/jats:p><jats:p>\n          Results The study encompassed 83 patients (70 females, 84.3%) with an\n                    average age of 57.2 years (24\u201380 years). The pathohistological analysis\n                    identified a total of 98 glands. In a per-lesion analysis, the detection rate of\n                        99mTc-sestamibi SPECT\/CT was 57% (95% CI 45.3\u201368.1), while the\n                    detection rate of 18F-choline PET\/CT was 90.3% (95% CI\n                    74.3\u201398.0).<\/jats:p><jats:p>\n          Conclusion The results of our study showed the significant usefulness of\n                        18F-choline PET\/CT in patients with negative or inconclusive\n                    results of 99mTc-sestamibi SPECT\/CT in accurately locating\n                    hyperfunctioning parathyroid glands in PHPT patients.<\/jats:p>","DOI":"10.1055\/a-2262-9249","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:03:50Z","timestamp":1707264230000},"page":"216-220","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic Performance of 99mTc-Sestamibi SPECT\/CT and\n                        18F-Choline PET\/CT in Locating Hyperfunctioning Parathyroid\n                    Glands in Patients with Primary Hyperparathyroidism"],"prefix":"10.1055","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4300-5154","authenticated-orcid":false,"given":"Ante","family":"Mandic","sequence":"additional","affiliation":[{"name":"University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb,\n                    Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Kraljevic","sequence":"additional","affiliation":[{"name":"University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb,\n                    Croatia"},{"name":"School of Medicine, University of Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Skoric Polovina","sequence":"additional","affiliation":[{"name":"University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb,\n                    Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Zibar Tomsic","sequence":"additional","affiliation":[{"name":"University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb,\n                    Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Dusek","sequence":"additional","affiliation":[{"name":"University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb,\n                    Croatia"},{"name":"School of Medicine, University of Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemarie","family":"Balasko","sequence":"additional","affiliation":[{"name":"University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb,\n                    Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirsala","family":"Solak","sequence":"additional","affiliation":[{"name":"University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb,\n                    Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darko","family":"Kastelan","sequence":"additional","affiliation":[{"name":"University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb,\n                    Croatia"},{"name":"School of Medicine, University of Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.beem.2018.09.004","article-title":"Primary hyperparathyroidism","volume":"32","author":"B C Silva","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00423-009-0533-5","article-title":"Positional statement of the European Society of Endocrine Surgeons (ESES) on\n                    modern techniques in pHPT surgery","volume":"394","author":"AO J 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Frank","year":"2020","journal-title":"Laryngoscope"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00423-009-0540-6","article-title":"Impact of modern techniques on short-term outcome after surgery for primary\n                    hyperparathyroidism: A multicenter study comprising 2,708 patients","volume":"394","author":"AO J Bergenfelz","year":"2009","journal-title":"Langenbecks Arch Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jamcollsurg.2009.05.029","article-title":"National trends in parathyroid surgery from 1998 to 2008: A decade of\n                    change","volume":"209","author":"A B Greene","year":"2009","journal-title":"J Am Coll Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0140-6736(09)60507-9","article-title":"Hyperparathyroidism","volume":"374","author":"W D Fraser","year":"2009","journal-title":"The 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ultrasound","volume":"407","author":"C Lenschow","year":"2022","journal-title":"Langenbecks Arch Surg"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2262-9249.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:36:25Z","timestamp":1730810185000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2262-9249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":27,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2024,4,15]]},"published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2262-9249","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2,6]]},"published":{"date-parts":[[2024,2,6]]}}}