{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:56:24Z","timestamp":1769111784069,"version":"3.49.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diosgenin is a sapogenin with antidiabetic, antioxidant, and anti-inflammatory\n                    properties. The current study investigated whether diosgenin could ameliorate\n                    carbon tetrachloride (CCL4)-induced liver injury. To cause liver injury, CCL4\n                    was injected intraperitoneally twice a week for 8 weeks. Daily oral\n                    administration of diosgenin at doses of 20, 40, and 80\u2009mg\/kg was started one day\n                    before CCL4 injection and continued for 8 weeks. Finally, serum levels of\n                    aspartate aminotransferase (AST), alanine aminotransferase (ALT), and also\n                    albumin were assessed. Catalase and superoxide dismutase (SOD) activities in\n                    addition to glutathione (GSH) and malondialdehyde (MDA) levels were also\n                    quantified in the liver homogenate and routine histological evaluation was also\n                    conducted. Elevated serum levels of liver enzymes and decreased serum level of\n                    albumin caused by CCL4 were significantly restored following diosgenin\n                    administration at doses of 40 and 80\u2009mg\/kg. Long-term administration of CCL4\n                    increased inflammatory and apoptotic factors such as IL-1\u03b2, caspase 3, TNF-\u03b1,\n                    and IL-6 and decreased SOD and catalase activities as well as GSH level in liver\n                    homogenates; while MDA level was increased. Treatment with diosgenin increased\n                    SOD and catalase activities and GSH levels in the liver of injured animals. In\n                    addition, liver MDA, IL-1\u03b2, caspase 3, TNF-\u03b1, and IL-6 level or activity\n                    decreased by diosgenin treatment. Additionally, diosgenin aptly prevented\n                    aberrant liver histological changes. According to obtained results, diosgenin\n                    can dose-dependently diminish CCl4-induced liver functional deficits and\n                    histological changes in a dose-dependent manner, possibly due to its antioxidant\n                    and anti-inflammation properties, and its beneficial effect is comparable to\n                    known hepatoprotective agent silymarin.<\/jats:p>","DOI":"10.1055\/a-2263-1329","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T23:51:40Z","timestamp":1709941900000},"page":"156-163","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic Potential of Diosgenin in Amelioration of Carbon\n                    Tetrachloride-Induced Murine Liver Injury"],"prefix":"10.1055","volume":"74","author":[{"given":"Mohamad-Hasan","family":"Ghosian-Moghaddam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Shahed University,\n                    Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvaneh","family":"Mohseni-Moghaddam","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Tehran Medical Sciences,\n                    Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-8484","authenticated-orcid":false,"given":"Mehrdad","family":"Roghani","sequence":"additional","affiliation":[{"name":"Neurophysiology Research Center, Shahed University, Tehran,\n                    Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-020-02906-7","article-title":"Poncirin attenuates CCL4-induced liver injury through inhibition of oxidative\n                    stress and inflammatory cytokines in 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cisplatin\n                    induced hepatotoxicity in rats","volume":"4","author":"V V Nimbalkar","year":"2018","journal-title":"International Journal of Clinical and Biomedical\n                    Research"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cbi.2013.08.014","article-title":"PPAR\u2019s and Diosgenin a chemico biological insight in NIDDM","volume":"206","author":"M Sangeetha","year":"2013","journal-title":"Chem Biol Interact"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e0153087","DOI":"10.1371\/journal.pone.0153087","article-title":"Hepatoprotective effect of wheat-based solid-state fermented Antrodia cinnamomea\n                    in carbon tetrachloride-induced liver injury in rat","volume":"11","author":"H-W Chiu","year":"2016","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/0269881117742666","article-title":"Therapeutic potential of silymarin in chronic 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Diabetes, Metabolic Syndrome and Obesity: Targets and\n                    Therapy","author":"S Khateeb","year":"2022"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1615\/JEnvironPatholToxicolOncol.v31.i2.40","article-title":"Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating\n                    lipid peroxidation via enhancing antioxidant defense system during NMU-induced\n                    breast carcinoma","volume":"31","author":"J Jagadeesan","year":"2012","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.biopha.2016.12.068","article-title":"Diosgenin ameliorates development of neuropathic pain in diabetic rats:\n                    Involvement of oxidative stress and inflammation","volume":"86","author":"Z Kiasalari","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4103\/2231-0738.114870","article-title":"Diosgenin prevents hepatic oxidative stress, lipid peroxidation and molecular\n                    alterations in chronic renal failure rats","volume":"3","author":"J Manivannan","year":"2013","journal-title":"International Journal of Nutrition, Pharmacology, Neurological\n                    Diseases"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.bbalip.2019.04.010","article-title":"Diosgenin regulates cholesterol metabolism in hypercholesterolemic rats by\n                    inhibiting NPC1L1 and enhancing ABCG5 and ABCG8","volume":"1864","author":"R Li","year":"2019","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of\n                    Lipids"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"106580","DOI":"10.1016\/j.prostaglandins.2021.106580","article-title":"Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver\n                    injury in mouse","volume":"156","author":"I Tsukayama","year":"2021","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"ref37","first-page":"20323","article-title":"Diosgenin attenuates hepatic stellate cell activation through transforming\n                    growth factor-\u03b2\/Smad signaling pathway","volume":"8","author":"W-L Xie","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1080\/07853890.2022.2069854","article-title":"Role of silymarin as antioxidant in clinical management of chronic liver\n                    diseases: A narrative review","volume":"54","author":"A Aghemo","year":"2022","journal-title":"Ann Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/s41419-018-1136-2","article-title":"Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice\n                    via the concomitant inhibition of inflammation and induction of apoptosis","volume":"9","author":"C Dai","year":"2018","journal-title":"Cell Death Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e698","DOI":"10.1002\/iid3.698","article-title":"Diosgenin protects retinal pigment epithelial cells from inflammatory damage and\n                    oxidative stress induced by high glucose by activating AMPK\/Nrf2\/HO-1\n                    pathway","volume":"10","author":"Y Hao","year":"2022","journal-title":"Immun Inflamm Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.intimp.2019.01.047","article-title":"Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through\n                    attenuation of apoptosis, oxidative stress, and inflammation","volume":"70","author":"Z Khosravi","year":"2019","journal-title":"Int Immunopharmacol."}],"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2263-1329.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:07:35Z","timestamp":1730822855000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2263-1329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,8]]},"references-count":40,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2024,4,8]]},"published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2263-1329","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,8]]}}}