{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:32:07Z","timestamp":1793039527183,"version":"4.5.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is known that reactive oxygen species cause abnormal immune responses in the\n                    gut during inflammatory bowel diseases (IBD). Therefore, oxidative stress has\n                    been theorized as an agent of IBD development and antioxidant compounds such as\n                    vitamin C (L-ascorbic acid) have been studied as a new tool to treat IBD.\n                    Therefore, the potential of vitamin C to treat IBD was reviewed here as a\n                    critical discussion about this field and guide future research. Indeed, some\n                    preclinical studies have shown the beneficial effects of vitamin C in models of\n                    ulcerative colitis in mice and clinical and experimental findings have shown\n                    that deficiency in this vitamin is associated with the development of IBD and\n                    its worsening. The main mechanisms that may be involved in the activity of\n                    ascorbic acid in IBD include its well-established role as an antioxidant, but\n                    also others diversified actions. However, some experimental studies employed\n                    high doses of vitamin C and most of them did not perform dose-response curves\n                    and neither determined the minimum effective dose nor the ED50.\n                    Allometric extrapolations were also not made. Also, clinical studies on the\n                    subject are still in their infancy. Therefore, it is suggested that the research\n                    agenda in this matter covers experimental studies that assess the effective,\n                    safe, and translational doses, as well as the appropriate administration route\n                    and its action mechanism. After that, robust clinical trials to increase\n                    knowledge about the role of ascorbic acid deficiency in IBD patients and the\n                    effects of their supplementation in these patients can be encouraged.<\/jats:p>","DOI":"10.1055\/a-2263-1388","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T23:58:58Z","timestamp":1710201538000},"page":"149-155","source":"Crossref","is-referenced-by-count":9,"title":["Perspectives About Ascorbic Acid to Treat Inflammatory Bowel\n                    Diseases"],"prefix":"10.1055","volume":"74","author":[{"given":"Ian Richard Lucena","family":"Andriolo","sequence":"additional","affiliation":[{"name":"Medicine Course, Health School \u2013 University of Itajai Valley, Itajai,\n                    SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Venzon","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Graduate Program \u2013 University of Itajai Valley,\n                    Itajai, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Mota","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Federal University of Santa Catarina,\n                    Florian\u00f3polis, Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"ref1","first-page":"7654","article-title":"Treatment of Inflammatory Bowel Disease: A Comprehensive Review","volume":"8","author":"Z Cai","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/ibd\/izab039","article-title":"Aging and IBD: A New Challenge for Clinicians and Researchers","volume":"28","author":"A S Faye","year":"2022","journal-title":"Inflamm Bowel Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3390\/ijms24021526","article-title":"Pathophysiology of Inflammatory Bowel Disease: Innate Immune System","volume":"24","author":"A Saez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11894-019-0705-6.","article-title":"Evolving Epidemiology of IBD","volume":"21","author":"J W Windsor","year":"2019","journal-title":"Curr Gastroenterol Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrgastro.2015.34","article-title":"Epidemiology and risk factors for IBD","volume":"12","author":"A N Ananthakrishnan","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41575-020-00360-x","article-title":"The four epidemiological stages in the global evolution of inflammatory bowel\n                    disease","volume":"18","author":"G G Kaplan","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"765474","DOI":"10.3389\/fmed.2021.765474","article-title":"Treatment of Inflammatory Bowel Disease: A Comprehensive Review","volume":"8","author":"Z Cai","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.nutres.2019.03.005","article-title":"Hydroalcoholic extract of Tagetes erecta L. flowers, rich in the carotenoid\n                    lutein, attenuates inflammatory cytokine secretion and improves the oxidative\n                    stress in an animal model of ulcerative colitis","volume":"66","author":"M C Meurer","year":"2019","journal-title":"Nutr Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.2174\/1381612825666190123112647","article-title":"The Role of Antioxidants in Cancer, Friends or Foes?","volume":"24","author":"B Poljsak","year":"2018","journal-title":"Curr Pharm Des"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.2174\/1381612823666170321094711","article-title":"Vitamins in Heart Failure: Friend or Enemy?","volume":"23","author":"G Georgiopoulos","year":"2017","journal-title":"Curr Pharm Des"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1007\/s10620-017-4632-9","article-title":"Vitamin C Improves Gastroparesis in Diabetic Rats: Effects on Gastric\n                    Contractile Responses and Oxidative Stress","volume":"62","author":"L M Da Silva","year":"2017","journal-title":"Dig Dis Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"102117","DOI":"10.1016\/j.nano.2019.102117","article-title":"Vitamin C: One compound, several uses. Advances for delivery, efficiency and\n                    stability","volume":"24","author":"A C Carit\u00e1","year":"2020","journal-title":"Nanomedicine."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/10715769509147535","article-title":"Altered ascorbic acid status in the mucosa from inflammatory bowel disease\n                    patients","volume":"22","author":"G D Buffinton","year":"1995","journal-title":"Free Rad Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.jnutbio.2020.108485","article-title":"Ascorbic acid deficiency induces hepatic and intestinal expression of\n                    inflammation-related genes irrespective of the presence or absence of gut\n                    microbiota in ODS rats","volume":"86","author":"N Kawade","year":"2020","journal-title":"J Nutr Biochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jnutbio.2019.04.012","article-title":"Ascorbic acid deficiency increases hepatic expression of acute phase proteins\n                    through the intestine-derived IL-6 and hepatic STAT3 pathway in ODS rats","volume":"70","author":"N Kawade","year":"2019","journal-title":"J Nutr Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3177\/jnsv.68.481","article-title":"Low Ascorbic Acid Intake Induces Inflammatory Changes in Intestine and Liver of\n                    ODS Rats","volume":"68","author":"N Kawade","year":"2022","journal-title":"J Nutr Sci Vitaminol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.bbamem.2017.10.010","article-title":"Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated\n                    via transcriptional mechanisms","volume":"1860","author":"V S Subramanian","year":"2018","journal-title":"Biochim Biophys Acta"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1371\/journal.pone.0182313","article-title":"Cytokine production profile in intestinal mucosa of paediatric inflammatory\n                    bowel disease. 2017","volume":"12","author":"S Vitale","year":"2017","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1152\/ajpgi.00071.2018","article-title":"Tumor necrosis factor alpha reduces intestinal vitamin C uptake: a role for\n                    NF-\u03baB-mediated signaling","volume":"315","author":"V S Subramanian","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref20","first-page":"009","article-title":"Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten\n                    Micronutrient","volume":"3","author":"K A Dunleavy","year":"2021","journal-title":"Crohns Colitis 360"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.3748\/wjg.v28.i33.4834","article-title":"Prevalence and factors associated with vitamin C deficiency in inflammatory\n                    bowel disease","volume":"28","author":"B L Gordon","year":"2022","journal-title":"World J Gastroenterol"},{"key":"ref22","first-page":"20245","article-title":"Ascorbic acid ameliorates oxidative stress and inflammation in dextran sulfate\n                    sodium-induced ulcerative colitis in mice","volume":"8","author":"H Yan","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4162\/nrp.2018.12.2.101","article-title":"Effect of vitamin C on azoxymethane (AOM)\/dextran sulfate sodium (DSS)-induced\n                    colitis-associated early colon cancer in mice","volume":"12","author":"H J Jeon","year":"2018","journal-title":"Nutr Res 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           Sulfate-Induced Colitis Model in Rats","volume":"67","author":"T Honjo","year":"2021","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/jbm.a.36715","article-title":"Vitamin C and B3 as new biomaterials to alter intestinal stem cells","volume":"107","author":"Y Qi","year":"2019","journal-title":"J Biomed Mater Res A."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12986-021-00576-x","article-title":"Combined effect of vitamin C and vitamin D3 on intestinal epithelial barrier by\n                    regulating Notch signaling pathway","volume":"18","author":"F Qiu","year":"2021","journal-title":"Nutr Metab (Lond)"},{"key":"ref29","first-page":"106","article-title":"Preventive Effect of Vitamin C on Dextran Sulfate Sodium (DSS)-Induced Colitis\n                    via the Regulation of IL-22 and IL-6 Production in Gulo(-\/-) Mice","volume":"23","author":"H Jo","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3390\/antiox11101993","article-title":"Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid","volume":"11","author":"A G\u0119gotek","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3390\/nu13020615","article-title":"Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and\n                    Determination","volume":"13","author":"M Dosed\u011bl","year":"2021","journal-title":"Nutrients."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3390\/nu12051501","article-title":"Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent","volume":"12","author":"J Ka\u017amierczak-Bara\u0144ska","year":"2020","journal-title":"Nutrients."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12291-013-0375-3","article-title":"Vitamin C in disease prevention and cure: An overview","volume":"28","author":"S Chambial","year":"2013","journal-title":"Indian J Clin Biochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrc3340","article-title":"The NAD metabolome--a key determinant of cancer cell biology","volume":"12","author":"A Chiarugi","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbabio.2010.08.005","article-title":"The specificity of proton-translocating transhydrogenase for nicotinamide\n                    nucleotides","volume":"1807","author":"L Huxley","year":"2011","journal-title":"Biochim Biophys Acta"}],"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2263-1388.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:07:25Z","timestamp":1730822845000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2263-1388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":35,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2024,4,8]]},"published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2263-1388","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,11]]}}}