{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:51Z","timestamp":1740126831018,"version":"3.37.3"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective This study aimed to evaluate fetal epicardial fat thickness (EFT)\n                    together with fetal myocardial performance index (MPI) and its effects on\n                    neonatal outcomes in obese pregnant women.<\/jats:p><jats:p>\n          Materials and methods A total of 102 pregnant women, 51 obese and 51 of\n                    normal weight, were included in this prospective study. Fetal EFT, and MPI\n                    measurements were performed for all patients.<\/jats:p><jats:p>\n          Results Fetal EFT and Mod-MPI showed a statistically significant difference\n                    between obese pregnant women and the control group (p=0.0001, p=0.001). The\n                    optimal fetal EFT predictive cut-off value for the 5th-minute APGAR score below\n                    7 was 1.22\u2009mm, with a sensitivity of 86.96% and a specificity of 54.43%\n                    (p=0.001).<\/jats:p><jats:p>\n          Conclusion Fetal EFT and mod-MPI were higher in obese pregnant women. It is\n                    encouraging that fetal EFT predicts low APGAR, but more important information\n                    can be obtained if postnatal follow-up of these cardiac changes caused by\n                    obesity can be performed.<\/jats:p>","DOI":"10.1055\/a-2267-5478","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T23:37:27Z","timestamp":1710891447000},"page":"439-445","source":"Crossref","is-referenced-by-count":0,"title":["Fetal Epicardial Fat Thickness in Obese Pregnant Women: Its Effect on\n                    Fetal Cardiac Function and Neonatal Outcomes"],"prefix":"10.1055","volume":"228","clinical-trial-number":[{"clinical-trial-number":"nct05948319","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-2837","authenticated-orcid":false,"given":"\u015e\u00fckran","family":"Do\u011fru","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal Fetal Medicine,\n                    Necmettin Erbakan University Meram Faculty of Medicine, Meram,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Akku\u015f","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal Fetal Medicine,\n                    Necmettin Erbakan University Meram Faculty of Medicine, Meram,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dclfet Sena","family":"Metin","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Necmettin Erbakan Universitesi Meram Tip\n                    Fakultesi, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Acar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Necmettin Erbakan Universitesi Meram Tip\n                    Fakultesi, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1007\/s00246-014-0863-0","article-title":"The effects of pre-pregnancy obesity on fetal cardiac functions","volume":"35","author":"I Ece","year":"2014","journal-title":"Pediatr Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"59e.1","DOI":"10.1016\/j.ajog.2022.12.322","article-title":"Defining poor growth and stillbirth risk in pregnancy for infants of mothers\n                    with overweight and obesity","volume":"229","author":"N L Pritchard","year":"2023","journal-title":"Am J Obstet Gynecol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1097\/aog.0000000000004968","article-title":"Association between obesity and fetal acidosis at scheduled cesarean\n                    delivery","volume":"140","author":"C A DeBolt","year":"2022","journal-title":"Obstet Gynecol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1530\/rep-10-0074","article-title":"Obesity, pregnancy, inflammation, and vascular function","volume":"140","author":"F C Denison","year":"2010","journal-title":"Reproduction (Cambridge, England)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1007\/s00404-023-06951-8","article-title":"How to do a fetal cardiac scan","volume":"307","author":"P Quaresima","year":"2023","journal-title":"Arch Gynecol Obstet"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/uog.6272","article-title":"Modified myocardial performance index for evaluation of fetal cardiac function\n                    in pre-eclampsia","volume":"33","author":"O Api","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"416","DOI":"10.3978\/j.issn.2223-3652.2014.11.05","article-title":"Epicardial adipose tissue: far more than a fat depot","volume":"4","author":"A H Talman","year":"2014","journal-title":"Cardiovasc Diagn Ther"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1055\/s-2008-1062724","article-title":"The double role of epicardial adipose tissue as pro- and anti-inflammatory\n                    organ","volume":"40","author":"G Iacobellis","year":"2008","journal-title":"Horm Metab Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/jcu.22602","article-title":"Increased fetal epicardial fat thickness: A novel ultrasound marker for altered\n                    fetal metabolism in diabetic pregnancies","volume":"46","author":"M O Akkurt","year":"2018","journal-title":"J Clin Ultrasound"},{"key":"ref10","first-page":"1","article-title":"Obesity: preventing and managing the global epidemic. 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chronic disease","volume":"128","author":"S S Kim","year":"2016","journal-title":"Obstet Gynecol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"654817","DOI":"10.1155\/2013\/654817","article-title":"Maternal body mass index does not affect neonatal umbilical artery blood gas\n                    parameters","volume":"2013","author":"S E Chalouhi","year":"2013","journal-title":"J Pregnancy"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1515\/jpm-2015-0117","article-title":"The relationship between cesarean section rate in term singleton pregnancies,\n                    maternal weight, and weight gain during pregnancy","volume":"44","author":"A Trojner-Bregar","year":"2016","journal-title":"J Perinat Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1111\/obr.12455","article-title":"Association between perinatal outcomes and maternal pre-pregnancy body mass\n                    index","volume":"17","author":"P Liu","year":"2016","journal-title":"Obes Rev"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"158861","DOI":"10.1016\/j.bbalip.2020.158861","article-title":"Sex-specific responses in placental fatty acid oxidation, esterification and\n                    transfer capacity to maternal obesity","volume":"1866","author":"T L Powell","year":"2021","journal-title":"Biochimica et Biophysica Acta Mol Cell Biol Lipids"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.tjog.2018.08.012","article-title":"Flow mediated dilatation of Taiwanese women with normal singleton\n                    pregnancies","volume":"57","author":"W C Hou","year":"2018","journal-title":"Taiwan J Obstet Gynecol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.placenta.2014.05.006","article-title":"Maternal prepregnancy obesity is associated with higher risk of placental\n                    pathological lesions","volume":"35","author":"L Huang","year":"2014","journal-title":"Placenta"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/jog.15092","article-title":"Comparison of brachial artery flow-mediated dilatation, uterine artery Doppler,\n                    and umbilical artery Doppler measurements in obese and normal pregnant\n                    women","volume":"48","author":"S Aksin","year":"2022","journal-title":"J Obstet Gynaecol Res"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/pd.4499","article-title":"Maternal body mass index influences umbilical artery Doppler velocimetry in\n                    physiologic pregnancies","volume":"35","author":"L Sarno","year":"2015","journal-title":"Prenat Diagn"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1016\/j.jnutbio.2013.07.003","article-title":"Influence of gestational overfeeding on myocardial proinflammatory mediators in\n                    fetal sheep 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