{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:29Z","timestamp":1740126809757,"version":"3.37.3"},"reference-count":67,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n   Von wenigen Ausnahmen abgesehen ist derzeit die Evidenz wissenschaftlicher Erkenntnisse zur Frage der onkologischen Relevanz neurourologischer Erkrankungen noch gering. Am besten erforscht ist der Zusammenhang zwischen einer langj\u00e4hrigen bestehenden Querschnittl\u00e4hmung mit ihren Folgen f\u00fcr den unteren Harntrakt und dem Auftreten eines Harnblasenkarzinoms.\n    <\/jats:p><jats:p>\n    Diese Karzinome unterscheiden sich vielf\u00e4ltig von Harnblasenkarzinomen bei Patienten ohne Querschnittl\u00e4hmung: Die Patienten sind im Durchschnitt 20 Jahre j\u00fcnger, die Tumoren sind sehr h\u00e4ufig bereits muskelinvasiv und schlecht differenziert mit einem hohen Anteil an Plattenepithelkarzinomen, die Prognose ist schlecht. Diese Charakteristika treten auch bei querschnittgel\u00e4hmten Patienten ohne Dauerkatheterableitung der Harnblase auf.\n    <\/jats:p><jats:p>\n      Obwohl der pathophysiologische Zusammenhang im Detail noch ungekl\u00e4rt ist, so scheint doch der entscheidende Link zwischen einer Querschnittl\u00e4hmung und dem Auftreten eines Harnblasenkarzinoms das Vorliegen einer neurogenen Blase zu sein. Pathologische Druckverh\u00e4ltnisse in der Harnblase und h\u00e4ufige Harnwegsinfekte bzw. asymptomatische Bakteriurien infolge der neurogenen Fehlsteuerung der Harnblase k\u00f6nnten die pathophysiologisch entscheidenden Faktoren darstellen.\n    <\/jats:p><jats:p>\n    Insofern stellt das Harnblasenkarzinom bei chronisch querschnittgel\u00e4hmten Patienten einen Modelltumor nach einer Denervierung dar.\n    <\/jats:p><jats:p>\n   Die klinisch wichtige Frage eines Screenings erfordert zuk\u00fcnftige interdisziplin\u00e4re Forschungsans\u00e4tze.\n    <\/jats:p>","DOI":"10.1055\/a-2269-1222","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:10:02Z","timestamp":1712794202000},"page":"326-336","source":"Crossref","is-referenced-by-count":0,"title":["Onkologische Relevanz neurourologischer Erkrankungen"],"prefix":"10.1055","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3037-8066","authenticated-orcid":false,"given":"Ralf","family":"B\u00f6thig","sequence":"additional","affiliation":[{"name":"Abt. 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