{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:23Z","timestamp":1787004863940,"version":"build-2736575974"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The study aimed to evaluate salivary cortisol (SC) contamination and determine\n                    the associated factors in secondary adrenal insufficiency (SAI) patients treated\n                    with hydrocortisone (Hc). A randomized crossover trial involved SAI patients. SC\n                    was measured before the morning Hc dose, then at one, two, and four hours after.\n                    The procedure was performed twice on two days of a week: one day while taking Hc\n                    in tablet form (tablet set) and one day while taking Hc in capsule form (capsule\n                    set). Area under the curve (AUC) of SC levels over time was calculated in each\n                    participant for the two sets. SC contamination was defined as AUCtablet above\n                    the 95th percentile of AUCcapsule. Thirty-four patients (24 females and 10\n                    males) with a median age of 48 years were enrolled. Post-Hc dose SC levels were\n                    higher in tablet than in capsule set, particularly at one hour. Prevalence and\n                    extent of SC contamination were estimated to 32% and 88%, respectively. In\n                    capsule set, SC measured two hours after Hc intake showed the strongest\n                    correlation with AUC (r=0.88, p&lt;0.001). In multivariate analysis, serum\n                    potassium\u22653.9 mEq\/l was the only predictor for SC contamination [multi-adjusted\n                    OR (95% CI): 7.1 (1.4\u201336.1); p=0.018]. SC measured during the two hours after Hc\n                    intake is inaccurate for glucocorticoid replacement therapy assessment in SAI\n                    patients treated with Hc in tablet form.<\/jats:p>","DOI":"10.1055\/a-2271-0700","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T19:38:15Z","timestamp":1709753895000},"page":"566-573","source":"Crossref","is-referenced-by-count":4,"title":["Salivary Cortisol Measurement Contamination After Oral\n                    Hydrocortisone: A Randomized Crossover Trial"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7991-9885","authenticated-orcid":false,"given":"Melika","family":"Chihaoui","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis,\n                    Tunisia"},{"name":"Department of Endocrinology, La Rabta University Hospital, Tunis,\n                    Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Mouelhi","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis,\n                    Tunisia"},{"name":"Department of Endocrinology, La Rabta University Hospital, Tunis,\n                    Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bessem","family":"Hammami","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis,\n                    Tunisia"},{"name":"Laboratory of Biochemistry, La Rabta Hospital University, Tunis,\n                    Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibtissem","family":"Oueslati","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis,\n                    Tunisia"},{"name":"Department of Endocrinology, La Rabta University Hospital, Tunis,\n                    Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Khessairi","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis,\n                    Tunisia"},{"name":"Department of Endocrinology, La Rabta University Hospital, Tunis,\n                    Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Chaker","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis,\n                    Tunisia"},{"name":"Department of Endocrinology, La Rabta University Hospital, Tunis,\n                    Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Yazidi","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis,\n                    Tunisia"},{"name":"Department of Endocrinology, La Rabta University Hospital, Tunis,\n                    Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moncef","family":"Feki","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis,\n                    Tunisia"},{"name":"Laboratory of Biochemistry, La Rabta Hospital University, Tunis,\n                    Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1210\/jc.2006-0524","article-title":"The impact of glucocorticoid replacement regimens on metabolic outcome and\n                    comorbidity in hypopituitary patients","volume":"91","author":"H Filipsson","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/BF03345773","article-title":"Metabolic and cardiovascular profile in patients with Addison\u2019s disease under\n                    conventional glucocorticoid replacement","volume":"32","author":"R Giordano","year":"2009","journal-title":"J Endocrinol Invest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jocd.2016.02.002","article-title":"Bone mineral density in Sheehan\u2019s syndrome; prevalence of low bone mass and\n                    associated factors","volume":"19","author":"M Chihaoui","year":"2016","journal-title":"J Clin Densitom"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.7326\/0003-4819-120-3-199402010-00005","article-title":"Effect of glucocorticoid replacement therapy on bone mineral density in patients\n                    with Addison disease","volume":"120","author":"P M Zelissen","year":"1994","journal-title":"Ann Intern Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1210\/jc.2006-0076","article-title":"Oden et al. 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Endocrinol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1677\/joe.0.1690065","article-title":"Bioavailability of oral hydrocortisone in patients with congenital adrenal\n                    hyperplasia due to 21-hydroxylase deficiency","volume":"169","author":"E Charmandari","year":"2001","journal-title":"J Endocrinol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/cen.14006","article-title":"Residual endogenous corticosteroid production in patients with adrenal\n                    insufficiency","volume":"91","author":"A Vulto","year":"2019","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2271-0700.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:28:28Z","timestamp":1730806108000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2271-0700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,6]]},"references-count":30,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2024,7,30]]},"published-print":{"date-parts":[[2024,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2271-0700","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,6]]}}}