{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:52:09Z","timestamp":1792039929721,"version":"4.4.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"07","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["MOST 111-2314-B-037-070-MY3,NSTC 112-2314-B-037-050-MY3,NSTC 112-2314-B-037-090"],"award-info":[{"award-number":["MOST 111-2314-B-037-070-MY3,NSTC 112-2314-B-037-050-MY3,NSTC 112-2314-B-037-090"]}]},{"name":"Ministry of Health and Welfare","award":["12D1-IVMOHW02"],"award-info":[{"award-number":["12D1-IVMOHW02"]}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"crossref","award":["KMU-TC112A04,KMUH-SH11207,KMUH112-2M27,KMUH112-2M28,KMUH112-2M29,KMUH112-2R37,KMUH112-2R38,KMUH112-2R39"],"award-info":[{"award-number":["KMU-TC112A04,KMUH-SH11207,KMUH112-2M27,KMUH112-2M28,KMUH112-2M29,KMUH112-2R37,KMUH112-2R38,KMUH112-2R39"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004738","name":"E-Da Hospital","doi-asserted-by":"crossref","award":["EDAHS112014,EDAHS112029,EDDHP112001"],"award-info":[{"award-number":["EDAHS112014,EDAHS112029,EDDHP112001"]}],"id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Sessile serrated lesions (SSLs) are obscured lesions predominantly in the right-sided colon and associated with interval colorectal cancer; however, their prevalence and risk factors among younger individuals remain unclear.<\/jats:p>\n                  <jats:p>Methods This retrospective study enrolled individuals who underwent index colonoscopy. The primary outcome was the SSL prevalence in the younger (&lt;50 years) and older (\u226550 years) age groups, while the secondary outcomes included clinically significant serrated polyps (CSSPs). Multivariable logistic regression was employed to identify predictors.<\/jats:p>\n                  <jats:p>Results Of the 9854 eligible individuals, 4712 (47.8%) were categorized into the younger age group. Individuals in the younger age group exhibited lower prevalences of adenomas (22.6% vs. 46.2%; P&lt;0.001) and right-sided adenomas (11.2% vs. 27.2%; P&lt;0.001) compared with their older counterparts. However, both groups exhibited a similar prevalence of SSLs (7.2% vs. 6.5%; P=0.16) and CSSPs (10.3% vs. 10.3%;P=0.96). Multivariable analysis revealed that age 40\u201349 years (odds ratio [OR] 1.81, 95%CI 1.01\u20133.23), longer withdrawal time (OR 1.17, 95%CI 1.14\u20131.20, per minute increment), and endoscopist performance (OR 3.35, 95%CI 2.44\u20134.58) were independent predictors of SSL detection in the younger age group. No significant correlation was observed between adenoma and SSL detection rates among endoscopists.<\/jats:p>\n                  <jats:p>Conclusion SSLs are not uncommon among younger individuals. Moreover, diligent effort and expertise are of paramount importance in SSL detection. Future studies should explore the clinical significance of SSLs in individuals of younger age.<\/jats:p>","DOI":"10.1055\/a-2272-1911","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T18:50:42Z","timestamp":1708455042000},"page":"494-502","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence and predictive factors of colorectal sessile serrated lesions in younger individuals"],"prefix":"10.1055","volume":"56","author":[{"given":"Jen-Hao","family":"Yeh","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da DaChang Hospital, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Jen","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da DaChang Hospital, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daw-Shyong","family":"Perng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Chieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Health Examination, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Tung","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da DaChang Hospital, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Health Examination, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chia","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaw-Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"},{"name":"Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"M Arnold","year":"2017","journal-title":"Gut"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/S1470-2045(21)00199-6","article-title":"Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: an international population-based study","volume":"22","author":"R Cardoso","year":"2021","journal-title":"Lancet Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cgh.2020.02.026","article-title":"Differences in incidence and mortality trends of colorectal cancer worldwide based on sex, age, and anatomic location","volume":"19","author":"MC Wong","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.3748\/wjg.v22.i13.3516","article-title":"Serrated colorectal cancer: Molecular classification, prognosis, and response to 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