{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:26:26Z","timestamp":1775733986029,"version":"3.50.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose Ductus venosus (DV) Doppler velocimetry reflects fetal cardiac\n                    function. Gestational diabetes mellitus (GDM) is assumed to impair cardiac\n                    function due to fetal hyperglycemia. The purpose of this study was to assess the\n                    ability of DV Doppler to predict an adverse perinatal outcome (APO) in term\n                    pregnancies with GDM.<\/jats:p><jats:p>\n          Methods This is a retrospective cohort study including GDM pregnancies of\n                    singleton, non-anomalous fetuses without any signs of placental dysfunction. All\n                    GDM women who primarily had a vaginal delivery attempt and in which DV Doppler\n                    was examined from 37+0 weeks on were included. Receiver operating characteristic\n                    curve (ROC) analyses were performed to assess the predictive value of DV\n                    pulsatility index (DV-PI) regarding a composite APO (CAPO). Furthermore, a\n                    subgroup analysis was performed regarding the presence of a\n                    large-for-gestational-age (LGA) newborn.<\/jats:p><jats:p>\n          Results A total of n=89 cases were included. Overall, CAPO occurred in 26\n                    out of 89 cases (29.2%). All DV Doppler examinations showed a positive A wave.\n                    DV-PI was&gt;95th percentile in 8 out of 89 cases (9%). Overall, ROC analysis\n                    showed no significant association of DV-PI with CAPO (AUC=0.523, p=0.735).\n                    However, regarding individual APO parameters, ROC analysis showed a significant\n                    association of DV-PI with 5th-min AGPAR (AUC=0.960, p=0.027), which was not\n                    confirmed after exclusion of LGA cases.<\/jats:p><jats:p>\n          Conclusion In GDM pregnancies at term, DV Doppler sonography seems to have\n                    no benefit for APO prediction.<\/jats:p>","DOI":"10.1055\/a-2272-6743","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:27:03Z","timestamp":1711153623000},"page":"363-369","source":"Crossref","is-referenced-by-count":2,"title":["Role of Ductus Venosus Doppler Sonography for the Prediction of\n                    Perinatal Outcome in Term Pregnancies Complicated by Gestational Diabetes\n                    Mellitus"],"prefix":"10.1055","volume":"228","author":[{"given":"Oliver","family":"Graupner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Aachen,\n                    Aachen, Germany"},{"name":"Department of Obstetrics and Gynecology, Technical University of Munich\n                    Hospital Rechts der Isar, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Rath","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Aachen,\n                    Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Lecker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Aachen,\n                    Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Ritter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Aachen,\n                    Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Ritgen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Aachen,\n                    Aachen, Germany"},{"name":"Praenatal Plus, K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Enzensberger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Aachen,\n                    Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and adverse pregnancy outcomes","volume":"358","author":"HAPO Study Cooperative Research\n                        Group","year":"2008","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"100241","DOI":"10.1016\/j.xagr.2023.100241","article-title":"Prognostic accuracy of antenatal doppler ultrasound measures in predicting\n                    adverse perinatal outcomes for pregnancies complicated by diabetes: A systematic\n                    review","volume":"3","author":"B M Rane","year":"2023","journal-title":"AJOG Glob Rep"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1016\/S0020-7292(15)30033-3","article-title":"The International Federation of Gynecology and Obstetrics (FIGO) Initiative on\n                    gestational diabetes mellitus: A pragmatic guide for diagnosis, management, and\n                    care","volume":"131","author":"M Hod","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1055\/a-0800-8596","volume-title":"Dopplersonografie in der Schwangerschaft \u2013 Qualit\u00e4tsanforderungen der DEGUM und\n                    klinischer Einsatz (Teil 1) Doppler Sonography during Pregnancy \u2013 DEGUM Quality\n                    Standards and Clinical Applications","author":"R Faber","year":"2019"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1159\/000338003","article-title":"Fetal cardiac function: technical considerations and potential research and\n                    clinical applications","volume":"32","author":"F Crispi","year":"2012","journal-title":"Fetal Diagn Ther"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/uog.22134","article-title":"ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age\n                    fetus and fetal growth restriction","volume":"56","author":"C C Lees","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/uog.22163","article-title":"Effect of maternal diabetes on fetal heart function on echocardiography:\n                    systematic review and meta-analysis","volume":"57","author":"A L Depla","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1055\/s-0034-1371849.","article-title":"Beurteilung der fetalen kardialen Funktion \u2013 etablierte und neue Methoden\n                    [Assessment of fetal cardiac function \u2013 established and novel methods]","volume":"218","author":"C Enzensberger","year":"2014","journal-title":"Z Geburtshilfe Neonatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1111\/j.1471-0528.1987. tb02314.x","article-title":"Uterine artery blood velocities during contractions in pregnancy and labour\n                    related to intrauterine pressure","volume":"94","author":"T Janbu","year":"1987","journal-title":"Br J Obstet Gynaecol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1046\/j.1469-0705.1994.04050381.x","article-title":"Reference ranges for fetal venous and atrioventricular blood flow\n                    parameters","volume":"4","author":"K Hecher","year":"1994","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ijgo.2015.06.020","article-title":"FIGO Intrapartum Fetal Monitoring Expert Consensus Panel. FIGO consensus\n                    guidelines on intrapartum fetal monitoring: Cardiotocography","volume":"131","author":"D Ayres-de-Campos","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"H724","DOI":"10.1152\/ajpheart.1979.237.6.H724","article-title":"Preferential streaming of ductus venosus blood to the brain and heart in fetal\n                    lambs","volume":"237","author":"D I Edelstone","year":"1979","journal-title":"Am J Physiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/uog.7744.","article-title":"Ductus venosus velocimetry in monitoring pregnancy in women with pregestational\n                    diabetes mellitus","volume":"36","author":"S F Wong","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/uog.2784","article-title":"Ductus venosus shunting in growth-restricted fetuses and the effect of umbilical\n                    circulatory compromise","volume":"28","author":"T Kiserud","year":"2006","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1111\/aogs.13363","article-title":"Maternal diabetes alters the development of ductus venosus shunting in the\n                    fetus","volume":"97","author":"A Lund","year":"2018","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1111\/aogs.14570","article-title":"Comparison of ductus venosus Doppler and cerebroplacental ratio for the\n                    prediction of adverse perinatal outcome in high-risk pregnancies before and\n                    after 34\u2009weeks","volume":"102","author":"J Morales-Rosell\u00f3","year":"2023","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1111\/j.1471-0528.2009.02341.x","article-title":"Effects of gestational diabetes on fetal oxygen and glucose levels in vivo","volume":"116","author":"E Taricco","year":"2009","journal-title":"BJOG"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/uog.7573.","article-title":"Ductus venosus blood flow velocity waveform in diabetic pregnancies","volume":"36","author":"A Stuart","year":"2010","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000073191","article-title":"Cardiac function in fetuses of poorly-controlled pre-gestational diabetic\n                    pregnancies \u2013 a pilot study","volume":"56","author":"S F Wong","year":"2003","journal-title":"Gynecol Obstet Invest"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1590\/s0066-782x2004001300005","article-title":"Ductus venosus flow and myocardial hypertrophy in fetuses of diabetic\n                    mothers","volume":"83","author":"P Zielinsky","year":"2004","journal-title":"Arq Bras Cardiol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/0002-9378(95)90161-2","article-title":"Fetal venous, intracardiac, and arterial blood flow measurements in intrauterine\n                    growth retardation: relationship with fetal blood gases","volume":"173","author":"K Hecher","year":"1995","journal-title":"Am J Obstet Gynecol"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2272-6743.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:49:30Z","timestamp":1730814570000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2272-6743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":21,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2024,8,5]]},"published-print":{"date-parts":[[2024,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2272-6743","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,22]]}}}