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In contrast, TAM regulation of fibrogenesis and the inflammation mechanisms underlying metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and, ultimately, liver cancer has recently been revealed. GAS6 and PROS binding to phosphatidylserine exposed in outer membranes of apoptotic cells links TAMs, particularly MERTK, with hepatocellular damage. In addition, AXL and MERTK regulate the development of liver fibrosis and inflammation in chronic liver diseases. Acute hepatic injury is also mediated by the TAM system, as recent data regarding acetaminophen toxicity and acute-on-chronic liver failure have uncovered. Soluble TAM-related proteins, mainly released from activated macrophages and hepatic stellate cells after hepatic deterioration, are proposed as early serum markers for disease progression. In conclusion, the TAM system is becoming an interesting pharmacological target in liver pathology and a focus of future biomedical research in this field.<\/jats:p>","DOI":"10.1055\/a-2275-0408","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:08:46Z","timestamp":1708733326000},"page":"099-114","source":"Crossref","is-referenced-by-count":10,"title":["GAS6\/TAM Axis as Therapeutic Target in Liver Diseases"],"prefix":"10.1055","volume":"44","author":[{"given":"Anna","family":"Tutusaus","sequence":"additional","affiliation":[{"name":"Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, Barcelona, Catalunya, Spain"},{"name":"Barcelona Clinic Liver Cancer (BCLC) Group, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, Barcelona, Catalunya, Spain"},{"name":"Barcelona Clinic Liver Cancer (BCLC) Group, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garc\u00eda de Frutos","sequence":"additional","affiliation":[{"name":"Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, Barcelona, Catalunya, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Cardiovasculares (CIBERCV), Barcelona, Comunidad de Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Mar\u00ed","sequence":"additional","affiliation":[{"name":"Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, Barcelona, Catalunya, Spain"},{"name":"Barcelona Clinic Liver Cancer (BCLC) Group, Barcelona, 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