{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T09:10:43Z","timestamp":1781341843216,"version":"3.54.1"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Rationale The COVID-19 pandemic caused by the SARS-CoV-2 virus has led to health complications beyond respiratory symptoms, revealing multi-organ involvement, including potential gastrointestinal implications.<\/jats:p><jats:p>\n            Patient Concerns We present a case of a 40-year-old female without any history of achalasia who developed symptoms of the condition following a confirmed SARS-CoV-2 infection. Unusually, multiple esophageal ulcers were identified, which are not typically associated with achalasia.<\/jats:p><jats:p>\n            Diagnosis Achalasia and esophageal ulcers were confirmed through a series of examinations, including barium swallow, CT scan, and upper endoscopy. Furthermore, immunohistochemical staining of esophageal biopsy specimens revealed the presence of the SARS-CoV-2 spike protein, suggesting direct viral involvement.<\/jats:p><jats:p>\n            Interventions The patient was treated with calcium channel blockers and proton pump inhibitors and later underwent a peroral endoscopic myotomy (POEM) procedure following the resolution of her COVID-19 infection.<\/jats:p><jats:p>\n            Outcome After the POEM procedure, the patient made a good recovery.<\/jats:p><jats:p>\n            Lessons This case underscores the potential for SARS-CoV-2 to trigger gastrointestinal complications and emphasizes the need for ongoing patient management and further research into the long-term implications of COVID-19. Despite the single-case nature of this report, it contributes to the expanding understanding of the diverse and multi-systemic impact of COVID-19.<\/jats:p>","DOI":"10.1055\/a-2275-2423","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T22:48:38Z","timestamp":1713998918000},"page":"1943-1947","source":"Crossref","is-referenced-by-count":2,"title":["Achalasia Following SARS-CoV-2 Infection: A Case Report and Review of Literature"],"prefix":"10.1055","volume":"62","author":[{"given":"Jianbin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wenzhou Central Hospital, Wenzhou 325000, China"},{"name":"Department of Gastroenterology, The Dingli Clinical College of Wenzhou Medical University, Wenzhou 325000, Zhejiang province, China"},{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Shanghai University, Wenzhou 325000, Zhejiang province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-4623","authenticated-orcid":false,"given":"Huang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wenzhou Central Hospital, Wenzhou 325000, China"},{"name":"Department of Gastroenterology, The Dingli Clinical College of Wenzhou Medical University, Wenzhou 325000, Zhejiang province, China"},{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Shanghai University, Wenzhou 325000, Zhejiang province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wenzhou Central Hospital, Wenzhou 325000, China"},{"name":"Department of Gastroenterology, The Dingli Clinical College of Wenzhou Medical University, Wenzhou 325000, Zhejiang province, China"},{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Shanghai University, Wenzhou 325000, Zhejiang province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangchao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wenzhou Central Hospital, Wenzhou 325000, China"},{"name":"Department of Gastroenterology, The Dingli Clinical College of Wenzhou Medical University, Wenzhou 325000, Zhejiang province, China"},{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Shanghai University, Wenzhou 325000, Zhejiang province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wenzhou Central Hospital, Wenzhou 325000, China"},{"name":"Department of Gastroenterology, The Dingli Clinical College of Wenzhou Medical University, Wenzhou 325000, Zhejiang province, China"},{"name":"Department of Gastroenterology, The Second 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