{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:21:39Z","timestamp":1740162099234,"version":"3.37.3"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Group B streptococcus (GBS) is the leading cause of bacterial sepsis and meningitis in neonates worldwide, but brain abscess secondary to GBS is extremely rare. While temporal brain abscesses have been described as a sequelae of otogenic infections in children and adults, such a presentation has not been described in neonates.<\/jats:p><jats:p>\n          Case Description\u2003An 8-day-old female infant presented with a fever and irritability along with bilateral purulent otorrhea. Maternal GBS screening was negative, but the delivery was complicated by chorioamnionitis. Workup revealed neutrophilic pleocytosis in the cerebrospinal fluid and culture of the ear drainage was positive for GBS. Magnetic resonance imaging showed a circular lesion with rim enhancement within the left temporal lobe concerning for an abscess. The infant was treated with 14 days of intravenous vancomycin, cefepime, and metronidazole followed by 10 weeks of intravenous ampicillin. The hospital course was complicated by seizures and obstructive hydrocephalus requiring multiple neurosurgical interventions.<\/jats:p><jats:p>\n          Conclusion\u2003Brain abscess can occur as a sequela of GBS meningitis in neonates, but they are rare. Otogenic infections require prompt evaluation and treatment as they can progress to serious central nervous infections in neonates.<\/jats:p>","DOI":"10.1055\/a-2275-9482","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:05:46Z","timestamp":1708992346000},"page":"e106-e110","source":"Crossref","is-referenced-by-count":0,"title":["Group B Streptococcus Brain Abscess in a Neonate with Bilateral Otorrhea"],"prefix":"10.1055","volume":"14","author":[{"given":"Emily E.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Wright State University Boonshoft School of Medicine, Fairborn, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Van","family":"Nostrand","sequence":"additional","affiliation":[{"name":"Department of Neonatal-Perinatal Medicine, Wright State University Boonshoft School of Medicine, Dayton Children's Hospital and Pediatrix Neonatology of Ohio, Dayton, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1711-674X","authenticated-orcid":false,"given":"Shreyas","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Neonatal-Perinatal Medicine, Wright State University Boonshoft School of Medicine, Dayton Children's Hospital and Pediatrix Neonatology of Ohio, Dayton, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"F179","DOI":"10.1136\/fn.88.3.F179","article-title":"Long term outcome of neonatal meningitis","volume":"88","author":"J P Stevens","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1542\/peds.2011-3453","article-title":"Long-term outcomes of group B streptococcal meningitis","volume":"130","author":"R Libster","year":"2012","journal-title":"Pediatrics"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/INF.0b013e3181fab1e7","article-title":"Neonatal bacterial meningitis: 444 cases in 7 years","volume":"30","author":"J Gaschignard","year":"2011","journal-title":"Pediatr Infect Dis J"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"F173","DOI":"10.1136\/fn.88.3.F173","article-title":"Neonatal meningitis","volume":"88","author":"P T Heath","year":"2003","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"04","key":"ref5","first-page":"e12899","article-title":"Early-onset meningitis with group b streptococcus: the case of a female neonate with brain abscess in Iran","volume":"8","author":"Z Mosayebi","year":"2017","journal-title":"J Compr Pediatr"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"e20191881","DOI":"10.1542\/peds.2019-1881","article-title":"Management of infants at risk for group B streptococcal disease","volume":"144","author":"K M Puopolo","year":"2019","journal-title":"Pediatrics"},{"key":"ref7","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease\u2013revised guidelines from CDC, 2010","volume":"59","author":"J R Verani","year":"2010","journal-title":"MMWR Recomm Rep"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"e20170476","DOI":"10.1542\/peds.2017-0476","article-title":"The epidemiology, management, and outcomes of bacterial meningitis in infants","volume":"140","author":"L Ouchenir","year":"2017","journal-title":"Pediatrics"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0022-3476(05)83480-8","article-title":"Gram-negative enteric bacillary meningitis: a twenty-one-year experience","volume":"122","author":"M Unhanand","year":"1993","journal-title":"J Pediatr"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1001\/jamapediatrics.2016.4678","article-title":"A quantitative, risk-based approach to the management of neonatal early-onset sepsis","volume":"171","author":"M W Kuzniewicz","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00404-010-1439-8","article-title":"Group B streptococci colonization in pregnant women: risk factors and evaluation of the vaginal flora","volume":"283","author":"T T Rocchetti","year":"2011","journal-title":"Arch Gynecol Obstet"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1053\/j.semperi.2007.01.005","article-title":"Consequences of prophylaxis for group B streptococcal infections of the neonate","volume":"31","author":"R S Baltimore","year":"2007","journal-title":"Semin Perinatol"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1001\/jamapediatrics.2018.4826","article-title":"Epidemiology of invasive early-onset and late-onset group B streptococcal disease in the United States, 2006 to 2015: multistate laboratory and population-based surveillance","volume":"173","author":"S A Nanduri","year":"2019","journal-title":"JAMA Pediatr"},{"issue":"25","key":"ref15","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1056\/NEJMoa0806820","article-title":"Evaluation of universal antenatal screening for group B streptococcus","volume":"360","author":"M K Van Dyke","year":"2009","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.2147\/IDR.S291511","article-title":"Understanding factors in group B streptococcus late-onset disease","volume":"14","author":"A Berardi","year":"2021","journal-title":"Infect Drug Resist"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"e361","DOI":"10.1542\/peds.2012-1231","article-title":"Group B streptococcus late-onset disease: 2003-2010","volume":"131","author":"A Berardi","year":"2013","journal-title":"Pediatrics"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s12884-021-03731-7","article-title":"Biomarkers for a histological chorioamnionitis diagnosis in pregnant women with or without group B streptococcus infection: a case-control study","volume":"21","author":"J Ren","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clp.2014.10.004","article-title":"Bacterial meningitis in infants","volume":"42","author":"L C Ku","year":"2015","journal-title":"Clin Perinatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/adc.69.1_Spec_No.14","article-title":"Prospective surveillance of neonatal meningitis","volume":"69","author":"L Hristeva","year":"1993","journal-title":"Arch Dis Child"},{"issue":"06","key":"ref21","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3171\/jns.1988.69.6.0877","article-title":"Brain abscesses in neonates. A study of 30 cases","volume":"69","author":"D Renier","year":"1988","journal-title":"J Neurosurg"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1515\/crpm-2016-0005","article-title":"Late-onset brain abscess due to group B Streptococcus","volume":"5","author":"A Giannattasio","year":"2016","journal-title":"Case Rep Perinat Med"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00381-008-0751-0","article-title":"An unexpected intracranial pressure crisis: infant brain abscess of unusual aetiology","volume":"25","author":"J D Pasternak","year":"2009","journal-title":"Childs Nerv Syst"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/lio2.150","article-title":"Otogenic brain abscesses: a systematic review","volume":"3","author":"M J Duarte","year":"2018","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"08","key":"ref25","doi-asserted-by":"crossref","first-page":"574.e7","DOI":"10.1016\/j.cmi.2017.02.021","article-title":"Short-read whole genome sequencing for determination of antimicrobial resistance mechanisms and capsular serotypes of current invasive Streptococcus agalactiae recovered in the USA","volume":"23","author":"B J Metcalf","year":"2017","journal-title":"Clin Microbiol Infect"},{"issue":"04","key":"ref26","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1128\/CMR.00007-10","article-title":"Penetration of drugs through the blood-cerebrospinal fluid\/blood-brain barrier for treatment of central nervous system infections","volume":"23","author":"R Nau","year":"2010","journal-title":"Clin Microbiol Rev"},{"issue":"06","key":"ref27","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/FOC\/2008\/24\/6\/E6","article-title":"Brain abscess in children","volume":"24","author":"J P Sheehan","year":"2008","journal-title":"Neurosurg Focus"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1542\/peds.113.6.1765","article-title":"Intracerebral abscess in children: historical trends at Children's Hospital Boston","volume":"113","author":"H P Goodkin","year":"2004","journal-title":"Pediatrics"}],"container-title":["American Journal of Perinatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2275-9482.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T17:03:26Z","timestamp":1730826206000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2275-9482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":27,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,4,4]]},"published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2275-9482","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2157-6998","2157-7005"],"issn-type":[{"type":"print","value":"2157-6998"},{"type":"electronic","value":"2157-7005"}],"subject":[],"published-other":{"date-parts":[[2024,2,26]]},"published":{"date-parts":[[2024,2,26]]}}}